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Fabian Krause Department of Orthopaedic Surgery and Traumatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

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Helen Anwander Department of Orthopaedic Surgery and Traumatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

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itself does not lead to pain but the osteonecrosis of the highly innervated subchondral bone underneath the cartilage defect ( 7 ). Symptoms and diagnostic OLT is a predominantly male disease, mostly affecting patients in their thirties. Patients

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Alessio Bernasconi Orthopaedic and Traumatology Unit, Department of Public Health, “Federico II” Naples University, Naples, Italy

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François Lintz Clinique de l’Union, Saint-Jean, France

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Francesco Sadile Orthopaedic and Traumatology Unit, Department of Public Health, “Federico II” Naples University, Naples, Italy

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asymptomatic or becomes painful, with the exception of those (few) cases of advanced deformity and subsequent gait dysfunction. Foot kinematics in symptomatic and asymptomatic flatfeet do not differ significantly, therefore pain may depend on tissue wear and

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Sitanshu Barik Pediatric Orthopedic Surgery, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India

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Sebastian Farr Orthopedic Hospital Speising, Department of Pediatric Orthopaedics and Adult Foot and Ankle Surgery, Vienna, Austria

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Indications (number of hands) Mean age (Range) (years) Outcome Lam et al (2019) 3 Restricted motion at MCP joint (7/7) 22.8 (16–30) Range of motion improved in all patients Ho et al (2018) 20 Pain at MCP joint (1/1) 13

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Luca Pacchiarini Service of Orthopaedics and Traumatology, Department of Surgery, EOC, Lugano, Switzerland

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Lorenzo Massimo Oldrini Service of Orthopaedics and Traumatology, Department of Surgery, EOC, Lugano, Switzerland

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Pietro Feltri Service of Orthopaedics and Traumatology, Department of Surgery, EOC, Lugano, Switzerland

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Stefano Lucchina Service of Orthopaedics and Traumatology, Department of Surgery, EOC, Lugano, Switzerland
Surgical Department, Hand Surgery Unit EOC, Locarno’s Regional Hospital, Locarno, Switzerland
Locarno Hand Center, Locarno, Switzerland

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Giuseppe Filardo Service of Orthopaedics and Traumatology, Department of Surgery, EOC, Lugano, Switzerland
Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland

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Christian Candrian Service of Orthopaedics and Traumatology, Department of Surgery, EOC, Lugano, Switzerland
Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland

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tendinopathy with a rate of 1.4%, representing 10.1% of all complications (234 patients), and pain with a rate of 1.3% (220 patients). The fourth most common complication was complex regional pain syndrome (CRPS) with a rate of 1.1%, accounting for 8.0% of all

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Daniel Herren Schulthess Klinik, Zurich, Switzerland

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destruction of the cartilage. Conventional treatment includes analgesics and non-steroidal anti-inflammatory drugs. Intra-articular visco-supplementation with hyaluronic acid has been shown to be effective in terms of pain relief and improved functionality

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Di Zhao The Second Clinical School of Guangzhou University of Chinese Medicine, Guangzhou, China
Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China

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Ling-feng Zeng The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China

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Gui-hong Liang The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China

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Jian-ke Pan The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China

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Ming-hui Luo The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China

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Yan-hong Han The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China

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Jun Liu Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China
Guangdong Second Traditional Chinese Medicine Hospital (Guangdong Province Engineering Technology Research Institute of Traditional Chinese Medicine), Guangzhou, China
The fifth Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, China

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Wei-yi Yang The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China

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( 1 , 2 ). Especially for patients with moderate to severe OA, the effective management of chronic pain associated with OA is a major concern for clinicians. Although nonsteroidal anti-inflammatory drugs (NSAIDs) and opioids are currently the dominant

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Olga Savvidou First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece
These authors contributed equally to this manuscript

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Olympia Papakonstantinou Second Department of Radiology, National and Kapodistrian University of Athens, Medical School, Attikon University General Hospital, Athens, Greece
These authors contributed equally to this manuscript

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Eleftheria Lakiotaki First Department of Pathology, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece
These authors contributed equally to this manuscript

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Ioannis Zafeiris First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece

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Dimitra Melissaridou First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece

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Pinelopi Korkolopoulou First Department of Pathology, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece
Co-senior authors

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Panayiotis J. Papagelopoulos First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece
Co-senior authors

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peripheral chondrosarcoma. There are also exceedingly rare descriptions of periosteal Ewing sarcoma. 5 Regarding clinical symptoms, these are non-specific and include pain, local swelling and limited range of motion of the adjacent joint. Pain is usually

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Young Yi Department of Orthopaedic Surgery, Inje University, Seoul Paik Hospital, 85, 2-ga, Jeo-dong, Jung-gu, Seoul, 100-032, Republic of Korea

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Woochun Lee Seoul Foot and Ankle Center, Dubalo Orthopaedic Clinic, 764-30, Bang bae dong, Seochogu, Seoul, 06554, Republic of Korea.

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history of trauma or underlying disease, constitutes a relatively small proportion of ankle arthritis. 1 Ankle arthritis has low prevalence compared with knee or hip arthritis, but once it progresses, it can lead to pain, dysfunction and abnormal gait

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Xavier Crevoisier University Hospital Center (CHUV) and University of Lausanne (UNIL), Switzerland

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Mathieu Assal Foot and Ankle Center, Clinique la Colline, Geneva, Switzerland

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Katarina Stanekova University Hospital Center (CHUV) and University of Lausanne (UNIL), Switzerland

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-articular pain, the presence of transfer metatarsalgia and the presence of associated deformities including clawtoes, dislocation of the lesser MTP joints, flatfoot, etc. Radiological attention should be focussed on the congruence or incongruence of the first MTP

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Hamid Rahmatullah Bin Abd Razak Department of Bioengineering, Imperial College London, London, UK
Sengkang General Hospital, Singapore
Joint first authors

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Daniel Chew Faculty of Medicine, Imperial College London, London, UK
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Zepur Kazezian Department of Bioengineering, Imperial College London, London, UK

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Anthony M.J. Bull Department of Bioengineering, Imperial College London, London, UK

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therapy that may improve pain parameters and functionality for mild to moderate knee OA, despite the limited evidence. 10 Today, nSTRIDE ® (Biomet Biologics, Warsaw, IN, USA) is the only available APS for clinical use in patients with early to

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