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Maria A. Smolle Department of Orthopaedics and Trauma, Medical University of Graz, Austria

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Dimosthenis Andreou Department of General Orthopaedics and Tumour Orthopaedics, University Hospital Muenster, Germany

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Per-Ulf Tunn Tumour Orthopaedics, HELIOS Klinikum Berlin-Buch, Germany

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Andreas Leithner Department of Orthopaedics and Trauma, Medical University of Graz, Austria

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tumours were risk factors for instability. 10 The only protective factor against hip instability was a posterolateral approach. 10 Moreover, the authors concluded that a posterolateral approach, together with application of a synthetic device for

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Matías Sepúlveda Universidad Austral de Chile, Valdivia, Chile
Hospital Base de Valdivia, Valdivia, Chile
AO Foundation, PAEG Expert Group, Davos, Switzerland

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Cecilia Téllez Universidad Austral de Chile, Valdivia, Chile
Hospital Base de Valdivia, Valdivia, Chile

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Víctor Villablanca Universidad Austral de Chile, Valdivia, Chile
Hospital Base de Valdivia, Valdivia, Chile

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Estefanía Birrer Universidad Austral de Chile, Valdivia, Chile
Hospital Base de Valdivia, Valdivia, Chile

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after 1 year. Final limb-length discrepancy is <1 cm. The general risk of physeal injury in these fractures is described as approximately 52%, being higher according to the classification of Salter and Harris ( 2 ). Another factor that

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Frédéric Vauclair Department of Orthopaedics and Traumatology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland

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Patrick Goetti Department of Orthopaedics and Traumatology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland

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Ngoc Tram V. Nguyen Mayo Clinic, Rochester, Minnesota, USA

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Joaquin Sanchez-Sotelo Mayo Clinic, Rochester, Minnesota, USA

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risk factors for nonunion or infection with the potential to be corrected prior to further surgical management. These include smoking, poor nutritional status, metabolic disorders, immunosuppressant medications, active inflammatory processes and poor

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Di Zhao The Second Clinical School of Guangzhou University of Chinese Medicine, Guangzhou, China
Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China

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Ling-feng Zeng The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China

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Gui-hong Liang The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China

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Jian-ke Pan The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China

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Ming-hui Luo The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China

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Yan-hong Han The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China

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Jun Liu Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China
Guangdong Second Traditional Chinese Medicine Hospital (Guangdong Province Engineering Technology Research Institute of Traditional Chinese Medicine), Guangzhou, China
The fifth Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, China

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Wei-yi Yang The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China

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than existing treatments. Nerve growth factor (NGF) is a neurotrophic factor associated with pain signal transduction and nociceptor receptor gene expression ( 5 ). It is a nociceptor sensitizer and has been studied as a potential alternative target

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Jonathon C Coward Deaprtment of Orthopaedic Surgery, Royal Perth Hospital, Perth, Western Australia, Australia

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Stefan Bauer Chirurgie de l’Épaule, Service d’Orthopédie et Traumatologie, Ensemble Hospitalier de la Côte, Morges, Switzerland

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Stephanie M Babic Deaprtment of Orthopaedic Surgery, Royal Perth Hospital, Perth, Western Australia, Australia

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Charline Coron Chirurgie de l’Épaule, Service d’Orthopédie et Traumatologie, Ensemble Hospitalier de la Côte, Morges, Switzerland

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Taro Okamoto Deaprtment of Orthopaedic Surgery, Royal Perth Hospital, Perth, Western Australia, Australia
Chirurgie de l’Épaule, Service d’Orthopédie et Traumatologie, Ensemble Hospitalier de la Côte, Morges, Switzerland

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William G Blakeney Deaprtment of Orthopaedic Surgery, Royal Perth Hospital, Perth, Western Australia, Australia

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approaches that hold promise ( 8 ). These programmes for non-operative management are the first options for patients with higher risk profiles for complications/adverse events prior to surgical reconstruction or arthroplasty. Scientific evidence of higher

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Dominic Davenport Department of Trauma & Orthopaedics, Princess Royal University Hospital & King’s College Hospital, UK

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Venu Kavarthapu Department of Trauma & Orthopaedics, Princess Royal University Hospital & King’s College Hospital, UK

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has been described as the single most important factor in determining the risk of dislocation following THA. 9 Furthermore, instability and dislocation after primary THA is the most common single reason for revision surgery, accounting for 22

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Julia Riemenschneider Department of Trauma-, Hand- and Reconstructive Surgery, Goethe University, Frankfurt, Germany

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Jan Tilmann Vollrath Department of Trauma-, Hand- and Reconstructive Surgery, Goethe University, Frankfurt, Germany

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Nils Mühlenfeld Department of Trauma-, Hand- and Reconstructive Surgery, Goethe University, Frankfurt, Germany

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Johannes Frank Department of Trauma-, Hand- and Reconstructive Surgery, Goethe University, Frankfurt, Germany

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Ingo Marzi Department of Trauma-, Hand- and Reconstructive Surgery, Goethe University, Frankfurt, Germany

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Maren Janko Department of Trauma-, Hand- and Reconstructive Surgery, Goethe University, Frankfurt, Germany

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arthroplasty (THA) without or with a Burch–Schneider ring and lastly combined treatment methods ( 2 , 22 , 26 , 27 ). The ideal therapy regime is dependent on fracture pattern, individual risk factors and the availability of the treatment method in the

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Hua Luo Department of Orthopedics, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Chaojun Shen Department of Orthopedics, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Tongyou Qu Department of Pharmacy, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, Zhejiang China

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Lin Chen Department of Orthopedics, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Yue Sun Department of Orthopedics, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Yu Ren Department of Pharmacy, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, Zhejiang China

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with various factors, including brain disease, systemic disease, and neurosis. In clinical treatment, the symptoms of an epileptic seizure, referred to as drug-induced seizures caused by improper medication, appear occasionally. Drug-induced convulsion

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Akintunde George Centre for Integrated Bioprocessing Research, Department of Chemical Engineering, University of Bath, Bath, UK

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Marianne Ellis Centre for Integrated Bioprocessing Research, Department of Chemical Engineering, University of Bath, Bath, UK

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Harinderjit Singh Gill Department of Mechanical Engineering, University of Bath, Bath, UK

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have been performed on this phenomenon, and also highlights factors contributing to the success of hip arthroplasty surgery in sickle cell disease patients. Many studies have been carried out to evaluate the various cellular and molecular processes

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Maria Anna Smolle Department of Orthopaedics and Trauma, Medical University of Graz, Graz, Austria

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Lukas Leitner Department of Orthopaedics and Trauma, Medical University of Graz, Graz, Austria

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Nikolaus Böhler Department for Orthopedics and Traumatology, Kepler University Hospital GmbH, Linz, Austria

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Franz-Josef Seibert Department of Orthopaedics and Trauma, Medical University of Graz, Graz, Austria

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Mathias Glehr Department of Orthopaedics and Trauma, Medical University of Graz, Graz, Austria

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Andreas Leithner Department of Orthopaedics and Trauma, Medical University of Graz, Graz, Austria

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Introduction Since the 1960s, tobacco smoking has been a well-known risk factor for development of malignancies and cardiovascular disease, and has been associated with increased mortality rates. 1 – 3 According to the World Health

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