Giorgio Perino
Giorgio Perino
Department of Orthopedics and Orthopedic Surgery, University Medicine Greifswald, Greifswald, Germany
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Ivan De Martino
Ivan De Martino
Division of Orthopaedics and Traumatology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy
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Lingxin Zhang
Lingxin Zhang
Department of Pathology and Laboratory Medicine, Sinai Health System, Toronto, Canada
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Zhidao Xia
Zhidao Xia
Centre for Nanohealth, Swansea University Medical School, Singleton Park, Swansea, UK
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Jiri Gallo
Jiri Gallo
Department of Orthopaedics, Faculty of Medicine and Dentistry, University Hospital, Palacky University Olomouc, Czech Republic
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Shonali Natu
Shonali Natu
Department of Pathology, University Hospital of North Tees and Hartlepool NHS Foundation Trust, Stockton-on-Tees, UK
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David Langton
David Langton
Orthopaedic Department, Freeman Hospital, Newcastle upon Tyne, UK
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Monika Huber
Monika Huber
Pathologisch-bakteriologisches Institut, Otto Wagner Spital, Wien, Austria
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Anastasia Rakow
Anastasia Rakow
Department of Orthopedics and Orthopedic Surgery, University Medicine Greifswald, Greifswald, Germany
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Janosch Schoon
Janosch Schoon
Department of Orthopedics and Orthopedic Surgery, University Medicine Greifswald, Greifswald, Germany
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Enrique Gomez-Barrena
Enrique Gomez-Barrena
Servicio de Cirugía Ortopédica y Traumatología, Hospital Universitario La Paz-IdiPAZ, Universidad Autónoma de Madrid, Madrid, Spain
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Veit Krenn
Veit Krenn
MVZ-Zentrum für Histologie, Zytologie und Molekulare Diagnostik-GmbH, Trier, Germany
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/ALTR/ARMD has been found to be high in MoM HRA and MoM LHTHA implants even in asymptomatic patients and well-functioning implants in several reports 40 – 43 and also in MoM SHTHA 44 , 45 without detectable change in size or progression to soft tissue
Olga Savvidou
Olga Savvidou
First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece
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These authors contributed equally to this manuscript
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Olympia Papakonstantinou
Olympia Papakonstantinou
Second Department of Radiology, National and Kapodistrian University of Athens, Medical School, Attikon University General Hospital, Athens, Greece
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These authors contributed equally to this manuscript
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Eleftheria Lakiotaki
Eleftheria Lakiotaki
First Department of Pathology, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece
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These authors contributed equally to this manuscript
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Ioannis Zafeiris
Ioannis Zafeiris
First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece
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Dimitra Melissaridou
Dimitra Melissaridou
First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece
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Pinelopi Korkolopoulou
Pinelopi Korkolopoulou
First Department of Pathology, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece
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Panayiotis J. Papagelopoulos
Panayiotis J. Papagelopoulos
First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece
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reported that most cases of progression occurred in patients with multiple tumors. 67 Most cases of SPECS are low to intermediate grade, although tumours of higher grade are also possible. The tumour is far more common after maturity, usually 25 to 45
Timothy Bage
Timothy Bage
The Peripheral Nerve Injury Service, Queen Elizabeth Hospital Birmingham, Birmingham, UK
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Dominic M. Power
Dominic M. Power
The Peripheral Nerve Injury Service, Queen Elizabeth Hospital Birmingham, Birmingham, UK
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the severity of the injury. A Sunderland grade 4 and 5 injury will demonstrate no progression of the Tinel’s sign. A grade 3 injury will progress at no more than 1 mm per day. However, a Sunderland grade 2 or a low-grade Seddon axonotmesis may
Alessandro Bensa
Alessandro Bensa
Service of Orthopaedics and Traumatology, Department of Surgery, EOC, Lugano, Switzerland
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Alessandro Sangiorgio
Alessandro Sangiorgio
Service of Orthopaedics and Traumatology, Department of Surgery, EOC, Lugano, Switzerland
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Angelo Boffa
Angelo Boffa
Applied and Translational Research (ATR) Center, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
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Manuela Salerno
Manuela Salerno
Applied and Translational Research (ATR) Center, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
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Giacomo Moraca
Giacomo Moraca
Service of Orthopaedics and Traumatology, Department of Surgery, EOC, Lugano, Switzerland
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Giuseppe Filardo
Giuseppe Filardo
Service of Orthopaedics and Traumatology, Department of Surgery, EOC, Lugano, Switzerland
Applied and Translational Research (ATR) Center, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
Università della Svizzera Italiana, Faculty of Biomedical Sciences, Lugano, Switzerland
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Applied and Translational Research (ATR) Center, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
Università della Svizzera Italiana, Faculty of Biomedical Sciences, Lugano, Switzerland
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, biochemical, and biomechanical factors, all favoring the disease progression ( 7 , 8 ). Among these, inflammation plays a pivotal role in the pathophysiology of OA, with synovial membrane alterations and the release of pro-inflammatory cytokines in the whole
Charles Court
Charles Court
Department of Orthopedic Surgery and Traumatology, Spine and tumor Unit, Bicetre University Hospital, Assistance Publique Hôpitaux de Paris, Paris Saclay University, Le Kremlin-Bicêtre, France
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Leonard Chatelain
Leonard Chatelain
Department of Orthopedic Surgery and Traumatology, Spine and tumor Unit, Bicetre University Hospital, Assistance Publique Hôpitaux de Paris, Paris Saclay University, Le Kremlin-Bicêtre, France
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Barthelemy Valteau
Barthelemy Valteau
Department of Orthopedic Surgery and Traumatology, Spine and tumor Unit, Bicetre University Hospital, Assistance Publique Hôpitaux de Paris, Paris Saclay University, Le Kremlin-Bicêtre, France
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Charlie Bouthors
Charlie Bouthors
Department of Orthopedic Surgery and Traumatology, Spine and tumor Unit, Bicetre University Hospital, Assistance Publique Hôpitaux de Paris, Paris Saclay University, Le Kremlin-Bicêtre, France
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nature but do not involve the spinal (zone II of Denis). In fact, the progression of the subtype number in AO classification corresponds to the progression of instability and not to the frequency of neurological compromise. One should consider in type B
Andreas Fontalis
Andreas Fontalis
Royal National Orthopaedic Hospital NHS Trust, Brockley Hill, Stanmore, UK
Academic Unit of Bone Metabolism, University of Sheffield Medical School, Sheffield, UK
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Academic Unit of Bone Metabolism, University of Sheffield Medical School, Sheffield, UK
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Eustathios Kenanidis
Eustathios Kenanidis
Academic Orthopaedic Unit, Aristotle University Medical School, Papageorgiou General Hospital, Thessaloniki, Greece
Centre of Orthopaedic and Regenerative Medicine (CORE), Center for Interdisciplinary Research and Innovation (CIRI), Aristotle University of Thessaloniki, Thessaloniki, Greece
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Centre of Orthopaedic and Regenerative Medicine (CORE), Center for Interdisciplinary Research and Innovation (CIRI), Aristotle University of Thessaloniki, Thessaloniki, Greece
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Katharine Bennett-Brown
Katharine Bennett-Brown
Chelsea and Westminster Hospital NHS Foundation Trust, Chelsea, London, UK
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Eleftherios Tsiridis
Eleftherios Tsiridis
Academic Orthopaedic Unit, Aristotle University Medical School, Papageorgiou General Hospital, Thessaloniki, Greece
Centre of Orthopaedic and Regenerative Medicine (CORE), Center for Interdisciplinary Research and Innovation (CIRI), Aristotle University of Thessaloniki, Thessaloniki, Greece
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Centre of Orthopaedic and Regenerative Medicine (CORE), Center for Interdisciplinary Research and Innovation (CIRI), Aristotle University of Thessaloniki, Thessaloniki, Greece
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. Our findings suggest that PD patients did not experience increased mortality in the immediate postoperative period compared to controls; however, long-term follow-up data showed a higher mortality risk, likely attributed to the disease progression
Amer Sebaaly
Amer Sebaaly
School of Medicine, Saint Joseph University, Beirut, Lebanon
Orthopedic Department, Spine Unit, Hotel Dieu de France Hospital, Beirut, Lebanon
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Orthopedic Department, Spine Unit, Hotel Dieu de France Hospital, Beirut, Lebanon
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Sarah Farjallah
Sarah Farjallah
Orthopedic Department, Spine Unit, Hotel Dieu de France Hospital, Beirut, Lebanon
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Khalil Kharrat
Khalil Kharrat
Orthopedic Department, Spine Unit, Hotel Dieu de France Hospital, Beirut, Lebanon
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Gaby Kreichati
Gaby Kreichati
School of Medicine, Saint Joseph University, Beirut, Lebanon
Orthopedic Department, Spine Unit, Hotel Dieu de France Hospital, Beirut, Lebanon
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Orthopedic Department, Spine Unit, Hotel Dieu de France Hospital, Beirut, Lebanon
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Mohammad Daher
Mohammad Daher
School of Medicine, Saint Joseph University, Beirut, Lebanon
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correlation between the extent of progression of the kyphosis and function ( 26 ). In other studies, untreated SK resulted in ‘severe thoracic spine pain’ in nearly 50% of the cases ( 27 , 28 ). Such discrepancies may be explained by the fact that these
E Carlos Rodríguez-Merchán
E Carlos Rodríguez-Merchán
Department of Orthopaedic Surgery, La Paz University Hospital, Madrid, Spain
Osteoarticular Surgery Research, Hospital La Paz Institute for Health Research – IdiPAZ (La Paz University Hospital – Autonomous University of Madrid), Madrid, Spain
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Osteoarticular Surgery Research, Hospital La Paz Institute for Health Research – IdiPAZ (La Paz University Hospital – Autonomous University of Madrid), Madrid, Spain
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Carlos Kalbakdij-Sánchez
Carlos Kalbakdij-Sánchez
Department of Orthopaedic Surgery, Emirates Specialty Hospital, Dubai Healthcare City, Dubai, UAE
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from 34 (range: 28–52) to 59 (range: 25–76) on the KSS and KSFS, respectively. Functional outcome was related to disease progression and therefore variable ( 11 ). Table 1 Hoehn and Yahr scale for Parkinson’s disease ( 13 ). Stage
Pengqiang Lou
Pengqiang Lou
Liaoning University of Traditional Chinese Medicine, Shenyang, China
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Guangzhi Zhou
Guangzhi Zhou
Liaoning University of Traditional Chinese Medicine, Shenyang, China
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Bo Wei
Bo Wei
Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, China
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Xiaolei Deng
Xiaolei Deng
Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, China
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Decai Hou
Decai Hou
Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, China
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concentration at the junction of the thinner bone trabeculae in the necrotic area and the thicker bone trabeculae in the repaired area, eventually leading to the formation of a sclerotic zone ( 18 ). With the progression of the disease, the trabecular bone
Miklós Szendrői
Miklós Szendrői
Department of Orthopaedics, Semmelweis University, H-1082 Budapest, Üllői 78/b, Hungary
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Imre Antal
Imre Antal
Department of Orthopaedics, Semmelweis University, H-1082 Budapest, Üllői 78/b, Hungary
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Attila Szendrői
Attila Szendrői
Department of Urology, Semmelweis University, H-1082 Budapest, Üllői 78/b, Hungary
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Áron Lazáry
Áron Lazáry
National Center for Spinal Disorders, H-1126 Budapest, Királyhágó u.1., Hungary
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Péter Pál Varga
Péter Pál Varga
National Center for Spinal Disorders, H-1126 Budapest, Királyhágó u.1., Hungary
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explained by our finding that when comparing the Fuhrman grade of the initial tumour, progression in the grade of metastases was found in 40%, downgrading in 30% and the same grade in 30%. This explains that the final outcome for the patient depends more on
