Christos Garnavos
Christos Garnavos
Orthopaedic and Trauma Department, ‘Evangelismos’ General Hospital, Athens, Greece
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with respect to union time, union rate, or improvements in alignment, and proposed that additional studies are needed to determine the actual benefit of blocking screws in the treatment of infra-isthmal femoral shaft fractures treated with retrograde
Signe Steenstrup Jensen
Signe Steenstrup Jensen
Department of Orthopedic Surgery and Traumatology, Lillebaelt Hospital, Kolding, Denmark
Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark
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Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark
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Niels Martin Jensen
Niels Martin Jensen
Department of Orthopedic Surgery and Traumatology, Lillebaelt Hospital, Kolding, Denmark
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Per Hviid Gundtoft
Per Hviid Gundtoft
Department of Orthopedic Surgery and Traumatology, Aarhus University Hospital, Aarhus, Denmark
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Søren Kold
Søren Kold
Department of Orthopedic Surgery, Aalborg University Hospital, Aalborg, Denmark
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Robert Zura
Robert Zura
Department of Orthopedic Surgery, Louisiana State University Medical Center, New Orleans, Louisiana, USA
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Bjarke Viberg
Bjarke Viberg
Department of Orthopedic Surgery and Traumatology, Lillebaelt Hospital, Kolding, Denmark
Department of Orthopedic Surgery and Traumatology, Odense University Hospital, Odense, Denmark
Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark
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Department of Orthopedic Surgery and Traumatology, Odense University Hospital, Odense, Denmark
Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark
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fractures . Injury 2014 45 1653 – 1658 . ( https://doi.org/10.1016/j.injury.2014.06.025 ) 5. Santolini E West R Giannoudis PV . Risk factors for long bone fracture non-union: a stratification approach based on the level of the existing scientific
Patrick Butler
Patrick Butler
Department of Orthopaedic Surgery and Traumatology, Odense University Hospital, Odense, Denmark
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Josef Gorgis
Josef Gorgis
Department of Orthopaedic Surgery and Traumatology, Odense University Hospital, Odense, Denmark
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Bjarke Viberg
Bjarke Viberg
Department of Orthopaedic Surgery and Traumatology, Kolding Hospital – part of Hospital Lillebaelt, Kolding, Denmark
Department of Regional Health Research, University of Southern Denmark, Odense, Denmark
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Department of Regional Health Research, University of Southern Denmark, Odense, Denmark
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Søren Overgaard
Søren Overgaard
Department of Orthopaedic Surgery and Traumatology, Odense University Hospital, Odense, Denmark
Department of Clinical Research, University of Southern Denmark, Odense, Denmark
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Department of Clinical Research, University of Southern Denmark, Odense, Denmark
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brand-new implants. Due to regulatory requirements, the tender of implants is mandatory in the European Union in order to have free-market regulation and a better price of a given product. 7 Minimum requirements are defined in these processes
Tobias Winkler
Tobias Winkler
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
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Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
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Sven Geissler
Sven Geissler
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
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Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
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Tazio Maleitzke
Tazio Maleitzke
Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
Trauma Orthopaedic Research Copenhagen Hvidovre (TORCH), Department of Orthopaedic Surgery, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
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Trauma Orthopaedic Research Copenhagen Hvidovre (TORCH), Department of Orthopaedic Surgery, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
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Carsten Perka
Carsten Perka
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
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Georg N Duda
Georg N Duda
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
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Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
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Alexander Hildebrandt
Alexander Hildebrandt
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
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Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
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starting point for early and targeted intervention strategies ( 25 ). While clinical intervention to date detects failed bone regeneration at later stages, when delayed or non-union occurs, evidence suggests that regeneration failure could be determined
Nick Evans
Nick Evans
University Hospital of Wales, Cardiff, UK
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Michael McCarthy
Michael McCarthy
University Hospital of Wales, Cardiff, UK
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decompression alone with regards to clinical outcome, and although they reported a non-union rate of 36%, this did not impact on the clinical outcome. 64 Surgeons have migrated towards instrumented PLF in an attempt to improve stability and subsequent
Simon M. Lambert
Simon M. Lambert
University College London Hospital, UK
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vascular territories (angiosomes) of the body: experimental study and clinical application . Br J Plast Surg 1987 ; 40 : 113 - 118 . 35. Papakonstantinou MK Hart MJ Farrugia R . Prevalence of non-union and delayed
Yun Yang
Yun Yang
Department of Orthopaedics, The Third People’s Hospital of Chengdu, Sichuan, PR China
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Yin-xiao Peng
Yin-xiao Peng
Department of Orthopaedics, The Third People’s Hospital of Chengdu, Sichuan, PR China
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Bin Yu
Bin Yu
Department of Orthopaedics, The Third People’s Hospital of Chengdu, Sichuan, PR China
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cases; non-union: four cases; femur rotational malalignment: one case; femur significant shortening: one case. Acetabular secondary procedures: three cases; heterotopic ossification: eight cases; significant loss of hip motion (<100° flexion): seven
Alan G. Fraser
Alan G. Fraser
Department of Cardiology, University Hospital of Wales, Cardiff, UK
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Rob G.H.H. Nelissen
Rob G.H.H. Nelissen
Department of Orthopaedics, Leiden University Medical Center, Leiden, Netherlands
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Per Kjærsgaard-Andersen
Per Kjærsgaard-Andersen
Department of Orthopaedics, Vejle Hospital, South Danish University, Vejle, Denmark
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Piotr Szymański
Piotr Szymański
Centre of Postgraduate Medical Education, MSWiA Central Clinical Hospital, Warsaw, Poland
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Tom Melvin
Tom Melvin
Healthcare Products Regulatory Authority, Earlsfort Terrace, Dublin 2, Ireland
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Paul Piscoi
Paul Piscoi
Health Technology Unit B6, Directorate General for Health (DG SANTE), European Commission, Brussels, Belgium
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On behalf of the CORE–MD Investigators (see Appendix)
On behalf of the CORE–MD Investigators (see Appendix)
Alan Fraser, Piotr Szymański, Chris Gale, Aldo Maggioni, Elisabetta Zanon, Christina Dimopoulou, Cinzia Ceccarelli, Polyxeni Vairami, Anett Ruszanov, Per Kjærsgaard-Andersen, Rob Nelissen, Adrian Ott, Elizabeth Macintyre, Loredana Simulescu, Marieke Meijer, Berthold Koletzko, Sarah Wieczorek, Adamos Hadjipanayis, Stefano Del Torso, Perla Marang-van de Mheen, Lotje Hoogervorst, Ewout W. Steyerberg, Bas Penning De Vries, Peter McCulloch, Martin Landray, Daniel Prieto Alhambra, James Smith, Anne Lubbeke-Wolf, Stefan James, Sergio Buccheri, Robert Byrne, Laurna McGovern, Stephan Windecker, Andre Frenk, Georgios Siontis, Christoph Stettler, Arjola Bano, Lia Bally, Frank E. Rademakers, Jan D‘hooge, Anton Vedder, Elisabetta Biasin, Erik Kamenjasevic, Petra Schnell-Inderst, Felicitas Kühne, Ola Rolfson, Joel Jakobsson, Amanda Tornsö, Enrico G. Caiani, Lorenzo Gianquintieri, Cinzia Cappiello, Maristella Matera, Tom Melvin, Niall MacAleenan, Ria Mahon, Michèle Meagher, Gearóid McGauran, Thomas Wejs Møller, Ann-Sofie Sonne Holm-Schou, Jan Szulc, Robert E. Geertsma, Jantine W.P.M. van Baal, Joëlle M. Hoebert, Susana L.F. Cabaço, Paola Laricchiuta, Marina Torre, Filippo Boniforti, Eugenio Carrani, Stefania Ceccarelli, Claudia Wild, Sabine Ettinger, Juan Antonio Blasco Amaro, Juan Carlos Rejón Parrilla, Agnieszka Dobrzynska, David Epstein, Valentina Strammiello, Hannes Jarke, Kaisa Immonen, Françoise Schlemmer, Sabina Hoekstra, Marianna Mastroroberto, Christoph Ziskoven, Michael Hahn, Erman Melikyan, Richard Holborow, Suzanne Halliday, Alexey Shiryaev, Gero Viola, Harry van Vugt
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Introduction Regulations concerning medical devices are shared across the European Union (EU) but verification that manufacturers conform to their requirements is devolved to independent notified bodies overseen by their national regulatory
Sebastian Siebenlist
Sebastian Siebenlist
Department of Orthopaedic Sports Medicine, Klinikum rechts der Isar, Technical University of Munich, Germany
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Arne Buchholz
Arne Buchholz
Department of Trauma Surgery, Klinikum rechts der Isar, Technical University of Munich, Germany
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Karl F. Braun
Karl F. Braun
Department of Trauma Surgery, Klinikum rechts der Isar, Technical University of Munich, Germany
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last decade. 65 , 66 , 70 Complications such as ulnar neuropathy, deep infection, implant failure or delayed/non-union are relatively rarely reported. However, an uneven reconstruction of the articular surface can cause sequelae such as limited
Michael J Raschke
Michael J Raschke
Department of Trauma-, Hand- and Reconstructive Surgery, University Hospital Muenster, Muenster, Germany
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Sabine Ochman
Sabine Ochman
Department of Trauma-, Hand- and Reconstructive Surgery, University Hospital Muenster, Muenster, Germany
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Alexander Milstrey
Alexander Milstrey
Department of Trauma-, Hand- and Reconstructive Surgery, University Hospital Muenster, Muenster, Germany
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particular. A conservative regimen leads to a higher amount of malunions and non-unions of up to 73%, whereas open reduction and internal fixation (ORIF) provides a consolidation rate up to 100% ( 13 , 14 ). However, the complication rate after surgery in
