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Thomas Tampere Department of Orthopaedic Surgery, Ghent University Hospital, Ghent, Belgium

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Matthieu Ollivier Institute for Locomotion, Aix-Marseille University, St. Marguerite Hospital, Marseille, France

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Christophe Jacquet Institute for Locomotion, Aix-Marseille University, St. Marguerite Hospital, Marseille, France

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Maxime Fabre-Aubrespy Institute for Locomotion, Aix-Marseille University, St. Marguerite Hospital, Marseille, France

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Sébastien Parratte Institute for Locomotion, Aix-Marseille University, St. Marguerite Hospital, Marseille, France
Department of Orthopaedic Surgery, International Knee and Joint Centre, Abu Dhabi, UAE

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infection. Attention should be paid to vascular and neurological evaluation of the involved limb with precise description in the medical record. Arthroplasty can be planned once the patient is in a stable condition, has been discharged from the intensive

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Chengxin Xie Department of Orthopedics, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Wenjun Pan Department of Orthopedics, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Shouli Wang Department of Orthopedics, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Xueli Yan Department of Orthopedics, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Hua Luo Department of Orthopedics, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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, which is more conducive to the functional recovery of the affected limb, reduces the occurrence of complications, overall cost and surgical trauma, and improves the level of patient satisfaction ( 9 ). Blom et al. highlighted that single-stage revision

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Inmaculada Moracia-Ochagavía Department of Orthopaedic Surgery, “La Paz” University Hospital-IdiPaz, Madrid, Spain

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E. Carlos Rodríguez-Merchán Department of Orthopaedic Surgery, “La Paz” University Hospital-IdiPaz, Madrid, Spain

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the first to describe the injury in 1815 and to describe an amputation at that level. 1 The use of this term is very broad and can refer to a low-energy sports injury or a high-energy lesion, as well as lesions that are purely ligamentous or those

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Benedikt J. Braun Department of Trauma, Hand and Reconstructive Surgery, Saarland University Hospital, Germany

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Bernd Grimm Luxembourg Institute of Health, Luxembourg

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Andrew M. Hanflik Los Alamitos Orthopaedics, Los Alamitos, California, USA

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Meir T. Marmor Department of Orthopaedic Surgery, University of California, San Francisco, California, USA

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Peter H. Richter Department of Trauma, Hand and Reconstructive Surgery, Saarland University Hospital, Germany

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Andrew K. Sands Weill Cornell Medical College, Foot and Ankle Surgery, Downtown Orthopedic Associates, New York Presbyterian Lower Manhattan Hospital, New York, USA

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Sureshan Sivananthan Orthopaedic Surgery, Pantai Hospital Kuala Lumpur, Malaysia

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production of orthotics or prosthetics after amputation. 59 , 60 Stage three is using the 3D print as the actual implant to provide a patient-specific and individualized solution, which can also assist with reduction. 61 , 62 The fourth stage is the

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Antal Imre Department of Orthopaedics, Semmelweis University, Budapest, Hungary

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Sápi Zoltán Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest

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Szendrői Miklós Department of Orthopaedics, Semmelweis University, Budapest, Hungary

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. Only one child presented with ossification of the growth plate in the lower limb, and there were six cases of hypercalcaemia (5.3 months after cessation of the treatment), typically in the paediatric population. In conclusion, presently the

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Vasileios P Giannoudis Major Trauma Centre, Leeds Teaching Hospitals NHS Trust
Academic Department of Trauma and Orthopaedics, School of Medicine, University of Leeds, United Kingdom

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Paul Rodham Major Trauma Centre, Leeds Teaching Hospitals NHS Trust
Academic Department of Trauma and Orthopaedics, School of Medicine, University of Leeds, United Kingdom

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Peter V Giannoudis Major Trauma Centre, Leeds Teaching Hospitals NHS Trust
Academic Department of Trauma and Orthopaedics, School of Medicine, University of Leeds, United Kingdom

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Nikolaos K Kanakaris Major Trauma Centre, Leeds Teaching Hospitals NHS Trust
Academic Department of Trauma and Orthopaedics, School of Medicine, University of Leeds, United Kingdom

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-vascularisation/acute amputation of ischaemic limbs Decompression of organ cavities (head, chest, abdomen and fascial compartments) + Definitive surgery/fixation later  Physiology   Lactate clearance (of high initial lactate): <60% from baseline

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Peter van Schie Department of Orthopaedics, Leiden University Medical Centre, Leiden, The Netherlands
Department of Biomedical Data Sciences, Medical Decision Making, Leiden University Medical Centre, Leiden, The Netherlands

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Shaho Hasan Department of Orthopaedics, Leiden University Medical Centre, Leiden, The Netherlands

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Leti van Bodegom-Vos Department of Biomedical Data Sciences, Medical Decision Making, Leiden University Medical Centre, Leiden, The Netherlands

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Jan W Schoones Walaeus Library, Leiden University Medical Centre, Leiden, The Netherlands

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Rob G H H Nelissen Department of Orthopaedics, Leiden University Medical Centre, Leiden, The Netherlands

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Perla J Marang-van de Mheen Department of Biomedical Data Sciences, Medical Decision Making, Leiden University Medical Centre, Leiden, The Netherlands

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arthrodesis or amputation – – – (C 1 ,C 2 )  Due to infection (31) (31) – –  Due to aseptic loosening – – (D 3 ) –  Not specified (15,20) (8) (D 1 ,D 2 ) (F 1 -F 3 ) 2a) Follow-up  Within

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Victor Lu School of Clinical Medicine, University of Cambridge, Cambridge, UK

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Maria Tennyson Department of Trauma and Orthopaedics, Addenbrooke’s Hospital, Cambridge, UK

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Andrew Zhou School of Clinical Medicine, University of Cambridge, Cambridge, UK

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Ravi Patel Department of Trauma and Orthopaedics, Shrewsbury and Telford Hospital NHS Trust, UK

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Mary D Fortune Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK

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Azeem Thahir Department of Trauma and Orthopaedics, Addenbrooke’s Hospital, Cambridge, UK

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Matija Krkovic Department of Trauma and Orthopaedics, Addenbrooke’s Hospital, Cambridge, UK

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(%) All infections (%) Implant failure Malunion or non-union Amputation (%) Periprosthetic fracture (%) Unplanned secondary surgery (%) Other post-operative complications Al-Nammari et al. (23) 2 (4.2) 1 (2.1 3 3 (6.3) 2

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