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Elisa Pala Department of Orthopedics and Orthopedic Oncology, University of Padova, Padova, Italy

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Giulia Trovarelli Department of Orthopedics and Orthopedic Oncology, University of Padova, Padova, Italy

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Andrea Angelini Department of Orthopedics and Orthopedic Oncology, University of Padova, Padova, Italy

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Maria Chiara Cerchiaro Department of Orthopedics and Orthopedic Oncology, University of Padova, Padova, Italy

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Pietro Ruggieri Department of Orthopedics and Orthopedic Oncology, University of Padova, Padova, Italy

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or opening of the medullary canal) ( 7 ). When this is not performed, the success rate decreases to 62% ( 3 ). Bone substitute materials seem to be the most effective for filling the cavity, with an efficacy of 87% despite autograft (63%) and

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Diogo Lino Moura Spine Unit, Department of Orthopedics, Coimbra University Hospital, Coimbra, Portugal, Coimbra, Portugal
Anatomy Institute and Orthopedics Department, Faculty of Medicine, University of Coimbra, Coimbra, Portugal

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morbidity of anterior approaches used for vertebral body corpectomy and replacement ( Fig. 1 ), even though showing good imaging and clinical outcomes, has led to an excessive trend to treat vertebral compression fractures merely by posterior pedicular

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Maria Anna Smolle Medical University of Graz, Austria

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Dimosthenis Andreou Münster University Hospital, Germany

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Per-Ulf Tunn Sarcoma Center Berlin-Brandenburg, HELIOS Klinikum Berlin-Buch, Germany

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Joanna Szkandera Medical University of Graz, Austria

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Bernadette Liegl-Atzwanger Medical University of Graz, Austria

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Andreas Leithner Medical University of Graz, Austria

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Soft-tissue swellings, lumps and bumps are frequently seen in routine clinical practice. However, with an estimated annual incidence of five cases per 100 000 people in Europe, soft-tissue sarcomas (STS) are relatively rare and are outnumbered by

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Xinhuan Lei Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Jie Xiang Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Hailan Yang Department of Ultrasound, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Hongya Bao Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Zhong Zhu Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Hua Luo Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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( 3 , 4 ), but others have found no statistical difference between IO and IV antibiotic administration ( 5 ). Because the incidence of SSI is relatively small, clinical research on the topic has shown ambiguous results and has been hampered by small

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Marilena Giannoudi Department of Cardiology, Bradford Teaching Hospitals NHS Trust, Bradford, UK
Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK

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Peter V Giannoudis Academic Department of Trauma and Orthopaedics, Floor D, Clarendon Wing, LGI, University of Leeds, Leeds, UK
NIHR Leeds Biomedical Research Centre, Chapel Allerton Hospital, Leeds, UK

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properties ( 7 , 8 , 9 , 10 , 11 , 12 , 13 ). Platelet inhibitor group/examples Mechanism of action Use in clinical practice Route of administration Time to peak plasma duration Route of excretion Cyclooxygenase inhibitors

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Nanne Kort CortoClinics, Nederweert, Netherlands

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Patrick Stirling ReSurg SA, Nyon, Switzerland

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Peter Pilot IMUKA, Roosteren, The Netherlands

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Jacobus Hendrik Müller ReSurg SA, Nyon, Switzerland

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purpose of this overview was therefore to summarize the findings of the most recent meta-analyses on the efficacy of robot-assisted versus conventional THA, and highlight any differences in surgical and clinical outcomes. This overview is expected to

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Maria E Dey Hazra Steadman Philippon Research Institute, Vail, Colorado, USA

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Rony-Orijit Dey Hazra Steadman Philippon Research Institute, Vail, Colorado, USA

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Jared A Hanson Steadman Philippon Research Institute, Vail, Colorado, USA

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Phob Ganokroj Steadman Philippon Research Institute, Vail, Colorado, USA
Faculty of Medicine Siriraj Hospital, Mahidol University

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Matthew L Vopat Steadman Philippon Research Institute, Vail, Colorado, USA
The Steadman Clinic, Vail, Colorado, USA

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Joan C Rutledge Steadman Philippon Research Institute, Vail, Colorado, USA

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Kohei Yamaura Steadman Philippon Research Institute, Vail, Colorado, USA

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Sunikom Suppauksorn Institute of Orthopaedics, Lerdsin General Hospital, Bangkok, Thailand

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Peter J Millett Steadman Philippon Research Institute, Vail, Colorado, USA
The Steadman Clinic, Vail, Colorado, USA

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irreparable rotator cuff tears (MIRCTs) ( 1 ). There are numerous clinical presentations of MIRCTs, ranging from pain or decreased range of motion to debilitating pseudoparalysis. First-line therapy for MIRCTs can be either non-operative or operative and is

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Thomas M Grupp Aesculap AG, Research & Development & Medical Scientific Affairs, Tuttlingen, Germany
Ludwig Maximilians University Munich, Department of Orthopaedic and Trauma Surgery, Musculoskeletal University Center Munich (MUM), Campus Grosshadern, Munich, Germany

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Sabine Rusch Aesculap AG, Research & Development & Medical Scientific Affairs, Tuttlingen, Germany

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Philippe Massin CMC Ambroise-Paré-Hartmann, Neuilly-sur-Seine, France

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Ashley Blom National Institute for Health Research Bristol Biomedical Research Centre, University Hospitals Bristol and Weston NHS Foundation Trust and the University of Bristol, Bristol, UK
Translational Health Sciences, Bristol Medical School, Musculoskeletal Research Unit, University of Bristol, Southmead Hospital, Bristol, UK

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Eduardo Garcia-Rey Hôpital Universitario La Paz-Idi Paz, Madrid, Spain
Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina, CIBER-BBN, Madrid, Spain

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Luca Cristofolini Department of Industrial Engineering, School of Engineering and Architecture, Alma Mater Studiorum - Università di Bologna, Bologna, Italy

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Dennis Janssen Radboud University Medical Center, Radboud Research Institute, Orthopaedic Research Lab, Nijmegen, the Netherlands

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Bernd Grimm Luxembourg Institute of Health, Human Motion, Orthopaedics, Sports Medicine & Digital Methods Group, Transversal Activities, Luxembourg

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Alexander Giurea Department of Orthopaedic Surgery, Medical University of Vienna, Vienna, Austria

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Marcus Jäger Department of Orthopaedics, Trauma & Reconstructive Surgery St. Marien Hospital Mülheim an der Ruhr & Chair of Orthopaedics and Trauma Surgery University of Duisburg–Essen, Essen, Germany

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Francesco Siccardi Medacta International SA, Research & Development & Medical Affairs, Castel San Pietro, Switzerland

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Søren Overgaard Copenhagen University Hospital, Department of Orthopaedic Surgery and Traumatology, Copenhagen, Denmark
Department of Clinical Medicine, Faculty of Health & Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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properties leads to uncertainty as to how to present (on the part of the applicant firm) and assess (on the part of the notified body and the clinical study surgeon) the methods and results of the pre-clinical and clinical evaluation ( 1 ). This ‘regulatory

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Anne Lübbeke Division of Orthopaedic Surgery and Traumatology, Geneva University Hospitals and University of Geneva, Switzerland
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK

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James A. Smith Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK
National Institute for Health Research Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK

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Daniel Prieto-Alhambra Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK

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Andrew J. Carr Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK
National Institute for Health Research Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK

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alone. 1 The development and implementation of medical devices has been questioned for reasons related to widespread clinical use of new devices without evidence of their safety and performance (e.g. metal-on-metal hip prostheses), 2 limited

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Tiago P Barbosa Hospital de Braga E.P.E., Braga, Portugal

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Ana Rita Raposo Hospital de Braga E.P.E., Braga, Portugal

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Paulo Diogo Cunha Hospital de Braga E.P.E., Braga, Portugal

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Nuno Cruz Oliveira Hospital de Braga E.P.E., Braga, Portugal

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Armanda Lobarinhas Hospital de Braga E.P.E., Braga, Portugal

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Pedro Varanda Hospital de Braga E.P.E., Braga, Portugal

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Bruno Direito-Santos Hospital de Braga E.P.E., Braga, Portugal

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cortical representation of the back, as well as modification of motor control patterns, may play a role ( 4 , 12 , 13 , 14 , 15 , 16 ). Furthermore, the therapist–patient relationship, changes in fear-avoidance beliefs, catastrophizing and self-efficacy

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