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Shaho Hasan Department of Orthopaedics, Leiden University Medical Centre, Leiden, The Netherlands

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Peter van Schie Department of Orthopaedics, Leiden University Medical Centre, Leiden, The Netherlands
Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands

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Bart L Kaptein Department of Orthopaedics, Leiden University Medical Centre, Leiden, The Netherlands

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Jan W Schoones Walaeus Library, Leiden University Medical Centre, Leiden, The Netherlands

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Perla J Marang-van de Mheen Department of Orthopaedics, Leiden University Medical Centre, Leiden, The Netherlands
Department of Safety & Security Science, Delft University of Technology, Delft, The Netherlands

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Rob G H H Nelissen Department of Orthopaedics, Leiden University Medical Centre, Leiden, The Netherlands

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was reported by three or more studies, results were plotted in a forest plot. Differences in biomarker values between loosened and stable implants were assessed at diagnosis or before surgery. In case of longitudinal data collection, the final

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Xiangji Dang Evidence-based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, P.R. China
Department of Pharmaceutical, Lanzhou University Second Hospital, Lanzhou, Gansu province, P.R. China

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Mei Liu The First Clinical Medical School, Gansu University of Chinese Medicine, Gansu, P.R. China

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Qiang Yang Department of Neurosurgery, Lanzhou University Second Hospital, Lanzhou, Gansu province, P.R. China

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Jin Jiang Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou, Gansu province, P.R. China

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Yan Liu Gansu High Throughput Screening and Creation Center for Health Products, School of Pharmacy, Lanzhou University, Lanzhou, P.R. China

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Hui Sun Cuiying Biomedical Research Center, Lanzhou University Second Hospital, Lanzhou, Gansu province, P.R. China

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Jinhui Tian Evidence-based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, P.R. China

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method, timing, or dosage of TXA administration; (ii) outcome evaluation time: the time frame for evaluating study outcomes was not restricted. Exclusion criteria were: (i) studies provided insufficient data; (ii) case reports, animal experiments

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Theofilos Karachalios Orthopaedic Department, University General Hospital of Larissa, Biopolis, Mezourlo Region, Larissa, Hellenic Republic
School of Health Sciences, Faculty of Medicine, University of Thessaly, Biopolis, Mezourlo Region, Larissa, Hellenic Republic

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Katre Maasalu Clinic of Traumatology and Orthopedics, Tartu University Hospital, Tartu, Estonia
Department of Traumatology and Orthopedics, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia

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Li Felländer-Tsai Division of Orthopaedics and Biotechnology, CLINTEC, Karolinska Institutet, Stockholm, Sweden
Trauma, Emergency Surgery and Orthopaedics, Reconstructive Orthopaedics, Karolinska University Hospital, Stockholm, Sweden

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). We report the results of a survey among European orthopaedic and trauma surgeons, under the auspices of the European Federation of Orthopaedics and Traumatology (EFORT), which assesses the perception, availability, usage, modification, compliance and

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Elcil Kaya Bicer Department of Orthopedics and Traumatology, Ege University Faculty of Medicine, Izmir, Turkey

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Heiner Fangerau Department of the History, Philosophy and Ethics of Medicine, Heinrich-Heine-Universität Düsseldorf, Germany

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Hakki Sur Department of Orthopedics and Traumatology, Ege University Faculty of Medicine, Izmir, Turkey

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-related published articles during the previous 3 years ( 11 ). This body of research was primarily focused on image interpretation and clinical decision-making. The most frequently reported AI-associated body region was the spine (43%), followed by the knee and hip

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Benedikt J. Braun Department of Trauma, Hand and Reconstructive Surgery, Saarland University Hospital, Germany

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Bernd Grimm Luxembourg Institute of Health, Luxembourg

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Andrew M. Hanflik Los Alamitos Orthopaedics, Los Alamitos, California, USA

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Meir T. Marmor Department of Orthopaedic Surgery, University of California, San Francisco, California, USA

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Peter H. Richter Department of Trauma, Hand and Reconstructive Surgery, Saarland University Hospital, Germany

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Andrew K. Sands Weill Cornell Medical College, Foot and Ankle Surgery, Downtown Orthopedic Associates, New York Presbyterian Lower Manhattan Hospital, New York, USA

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Sureshan Sivananthan Orthopaedic Surgery, Pantai Hospital Kuala Lumpur, Malaysia

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severe glenoid defect: a case report with 2.5 years of follow-up . J Shoulder Elbow Surg 2015 ; 24 : e218 – e222 . 63. Lee JM Yeong WY . Design and printing strategies in 3D bioprinting of cell-hydrogels: a review . Adv

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Martin McNally The Bone infection Unit, Nuffield Orthopaedic Centre, Oxford University Hospitals, Oxford, UK

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Irene Sigmund The Bone infection Unit, Nuffield Orthopaedic Centre, Oxford University Hospitals, Oxford, UK
Department of Orthopaedics and Trauma Surgery, Medical University of Vienna, Austria

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Andrew Hotchen The Bone infection Unit, Nuffield Orthopaedic Centre, Oxford University Hospitals, Oxford, UK

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Ricardo Sousa Porto Bone and Joint Infection Group (GRIP), Department of Orthopaedics, Centro Hospitalar Universitario Santo António and CUF-Hospitais e Clinicas, Portugal

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new data, from joint registries, has shown that we are missing many infected cases ( 2 , 3 ). Over 3200 papers were published on PJI between 1998 and 2018, with over 12,000 citations in 2018, alone ( 4 ). From this research, there has been a

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Keijo T. Mäkelä Turku University Hospital and University of Turku, Finland, and the Finnish Arthroplasty Register

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Ove Furnes Haukeland University Hospital, Bergen, Norway, and the Norwegian Arthroplasty Register

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Geir Hallan Haukeland University Hospital, Bergen, Norway, and the Norwegian Arthroplasty Register

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Anne Marie Fenstad Haukeland University Hospital, Bergen, Norway, and the Norwegian Arthroplasty Register

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Ola Rolfson Sahlgrenska University Hospital and University of Gothenburg, Sweden, and the Swedish Hip Arthroplasty Register

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Johan Kärrholm Sahlgrenska University Hospital and University of Gothenburg, Sweden, and the Swedish Hip Arthroplasty Register

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Cecilia Rogmark Department of Orthopedics, Skåne University Hospital, Department of Clinical Sciences Malmö, Lund University, and the Swedish Hip Arthroplasty Register, Sweden

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Alma Becic Pedersen Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark, and the Danish Hip Arthroplasty Register

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Otto Robertsson The Swedish Knee Arthroplasty Register, Department of Orthopedics, Skåne University Hospital, and Department of Clinical Sciences, Orthopedics, Lund University, Sweden

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Annette W-Dahl The Swedish Knee Arthroplasty Register, Department of Orthopedics, Skåne University Hospital, and Department of Clinical Sciences, Orthopedics, Lund University, Sweden

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Antti Eskelinen Coxa Hospital for Joint Replacement, Tampere, Finland, and the Finnish Arthroplasty Register

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Henrik M. Schrøder Department of Orthopaedic Surgery, Naestved Hospital, Denmark, and the Danish Knee Arthroplasty Register

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Ville Äärimaa Turku University Hospital and University of Turku, Finland, and the Finnish Arthroplasty Register

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Jeppe V. Rasmussen Department of Orthopaedic Surgery, Herlev Hospital, University of Copenhagen, Denmark, and the Danish Shoulder Arthroplasty Register

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Björn Salomonsson Department of Orthopedics, Karolinska Institutet, Danderyds Sjukhus AB, Sweden, and the Swedish Shoulder Arthroplasty Register

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Randi Hole Haukeland University Hospital, Bergen, Norway, and the Norwegian Arthroplasty Register

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Søren Overgaard Department of Orthopaedic Surgery and Traumatology, Odense University Hospital, Department of Clinical Research, University of Southern Denmark, and the Danish Hip Arthroplasty Register

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definitions and statistical methods used. Reports from the Nordic registers have further shown differences regarding the incidence and indication for surgery, characteristics of the joint replacement populations, implants used, fixation methods used and

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John-Henry Rhind Robert Jones Agnes Hunt Hospital, Oswestry, Shropshire, UK

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Eamon Ramhamadany Robert Jones Agnes Hunt Hospital, Oswestry, Shropshire, UK

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Ruaraidh Collins Basingstoke and North Hampshire Hospital, Basingstoke, Hampshire, UK

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Siddharth Govilkar Robert Jones Agnes Hunt Hospital, Oswestry, Shropshire, UK

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Debashis Dass Robert Jones Agnes Hunt Hospital, Oswestry, Shropshire, UK

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Stuart Hay Robert Jones Agnes Hunt Hospital, Oswestry, Shropshire, UK

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treatment. 41 In the pioneering unit for the virtual model, there are currently no medicolegal cases reported, after having managed 30,000 patients. 16 Another important limiting factor with the VFC model is internet access. In one study, 72% of

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Volkmar Jansson Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, University Hospital of Munich (LMU), Campus Grosshadern, Munich, Germany

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Alexander Grimberg German Arthroplasty Registry (EPRD Deutsche Endoprothesenregister gGmbH), Berlin, Germany

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Oliver Melsheimer German Arthroplasty Registry (EPRD Deutsche Endoprothesenregister gGmbH), Berlin, Germany

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Carsten Perka Charité Center for Orthopedics and Trauma Surgery, Charité University Hospital, Berlin, Germany

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Arnd Steinbrück Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, University Hospital of Munich (LMU), Campus Grosshadern, Munich, Germany
German Arthroplasty Registry (EPRD Deutsche Endoprothesenregister gGmbH), Berlin, Germany

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arthroplasty registry and, therefore, the number of hip and knee arthroplasty cases contributed, has been steadily growing annually. 4 Data collection by the EPRD proceeds in Germany on a voluntary basis. Participating hospitals grant consent for patients to

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Michael de Buys Orthopaedic Surgery, University of Witswatersrand, Johannesburg, South Africa

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Krisantha Moodley Emergency Department, ER Consulting, Johannesburg, South Africa

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Josip Nenad Cakic Department Orthopaedic Surgery, Life Fourways Hospital, Johannesburg, South Africa

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Jurek R T Pietrzak Orthopaedic Surgery, University of Witswatersrand, Johannesburg, South Africa

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impact of PJI was estimated at $1.62 billion in the USA in 2020 ( 10 ). The cost of revision procedures is reported to be as high as €80 000 per case; up to five times greater than the cost of primary TJA ( 8 ). A revision procedure for an infected THA in

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