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Di Zhao The Second Clinical School of Guangzhou University of Chinese Medicine, Guangzhou, China
Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China

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Ling-feng Zeng The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China

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Gui-hong Liang The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China

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Jian-ke Pan The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China

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Ming-hui Luo The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China

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Yan-hong Han The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China

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Jun Liu Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China
Guangdong Second Traditional Chinese Medicine Hospital (Guangdong Province Engineering Technology Research Institute of Traditional Chinese Medicine), Guangzhou, China
The fifth Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, China

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Wei-yi Yang The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China

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that included information on the Western Ontario and McMaster Universities Osteoarthritis Index (WOAMC) pain score (scale of 0–10), WOMAC physical function score (scale of 0–10), patient’s global assessment (PGA) (5-point Likert scale), number of

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Luca Pacchiarini Service of Orthopaedics and Traumatology, Department of Surgery, EOC, Lugano, Switzerland

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Lorenzo Massimo Oldrini Service of Orthopaedics and Traumatology, Department of Surgery, EOC, Lugano, Switzerland

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Pietro Feltri Service of Orthopaedics and Traumatology, Department of Surgery, EOC, Lugano, Switzerland

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Stefano Lucchina Service of Orthopaedics and Traumatology, Department of Surgery, EOC, Lugano, Switzerland
Surgical Department, Hand Surgery Unit EOC, Locarno’s Regional Hospital, Locarno, Switzerland
Locarno Hand Center, Locarno, Switzerland

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Giuseppe Filardo Service of Orthopaedics and Traumatology, Department of Surgery, EOC, Lugano, Switzerland
Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland

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Christian Candrian Service of Orthopaedics and Traumatology, Department of Surgery, EOC, Lugano, Switzerland
Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland

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the mean and s.d. , and a meta-analysis was not feasible due to the heterogeneity of the included studies. Assessment of risk of bias and quality of evidence The Downs and Black’s ‘Checklist for Measuring Quality’ was used to evaluate the risk

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Peter van Schie Department of Orthopaedics, Leiden University Medical Centre, Leiden, The Netherlands
Department of Biomedical Data Sciences, Medical Decision Making, Leiden University Medical Centre, Leiden, The Netherlands

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Shaho Hasan Department of Orthopaedics, Leiden University Medical Centre, Leiden, The Netherlands

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Leti van Bodegom-Vos Department of Biomedical Data Sciences, Medical Decision Making, Leiden University Medical Centre, Leiden, The Netherlands

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Jan W Schoones Walaeus Library, Leiden University Medical Centre, Leiden, The Netherlands

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Rob G H H Nelissen Department of Orthopaedics, Leiden University Medical Centre, Leiden, The Netherlands

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Perla J Marang-van de Mheen Department of Biomedical Data Sciences, Medical Decision Making, Leiden University Medical Centre, Leiden, The Netherlands

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). Risk of bias assessment The Integrated Quality Criteria for Review of Multiple Study Designs (ICROMS) was used to assess the risk of bias (RoB) independently by both reviewers (PvS/SH) ( 26 ). The ICROMS is a comprehensive tool to evaluate the quality

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Pietro Feltri Orthopaedics and Traumatology Clinic, EOC, Lugano, Switzerland

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Camilla Mondini Trissino da Lodi Orthopaedics and Traumatology Clinic, EOC, Lugano, Switzerland

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Alberto Grassi II Clinica, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

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Stefano Zaffagnini II Clinica, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

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Christian Candrian Orthopaedics and Traumatology Clinic, EOC, Lugano, Switzerland
Facoltà di Scienze Biomediche, Università della Svizzera Italiana, Lugano, Switzerland

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Giuseppe Filardo Orthopaedics and Traumatology Clinic, EOC, Lugano, Switzerland
Applied and Translational Research Center, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
Facoltà di Scienze Biomediche, Università della Svizzera Italiana, Lugano, Switzerland

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. Note . UKR, unicondylar knee replacement. Assessment of risk of bias and quality of evidence All studies were evaluated according to the level of evidence (LOE), using previously published criteria. 18 To establish potential bias in the

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Lukas Fraissler University of Würzburg, Germany

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Christian Konrads University of Würzburg, Germany

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Maik Hoberg University of Würzburg, Germany

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Maximilian Rudert University of Würzburg, Germany

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Matthias Walcher University of Würzburg, Germany

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1993 ; 14 : 181 - 5 . 13 Easley ME , Trnka HJ . Current concepts review: hallux valgus part 1: pathomechanics, clinical assessment, and nonoperative management . Foot Ankle Int 2007 ; 28 : 654 - 9 . 14 Coughlin

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Thomas Collins Trauma & Orthopaedics, Wythenshawe Hospital, Wythenshawe, UK

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Dinesh Alexander Trauma & Orthopaedics, Salford Royal Hospital, Salford, UK

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Bilal Barkatali Trauma & Orthopaedics, Salford Royal Hospital, Salford, UK

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commercial interest following PRP use in professional sport. 8 This review aims to synopsise PRP use in musculoskeletal pathologies through evidence-based assessment of the preparation, classification systems, mechanism of action and clinical

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Antomio Capone Orthopaedic and Trauma Unit, Department of Surgical Sciences, University of Cagliari, Italy

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Marcella Peri Department of Surgical Sciences, University of Cagliari, Italy

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Michele Mastio Orthopaedic and Trauma Unit, Department of Surgical Sciences, University of Cagliari, Italy

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were entered onto a spreadsheet (Excel; Microsoft Corp., Redmond, Washington) as raw numbers where possible, plus any summary measures such as standard deviations ( sd ), 95% confidence intervals (CIs) and ranges. Quality assessment All studies

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Olga Savvidou First Department of Orthopedics, National and Kapodistrian University of Athens, Medical School, ATTIKON University General Hospital, Greece
These authors contributed equally to this manuscript

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Olympia Papakonstantinou Second Department of Radiology, National and Kapodistrian University of Athens, Medical School, ATTIKON University General Hospital, Athens, Greece
These authors contributed equally to this manuscript

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Eleftheria Lakiotaki First Department of Pathology, National and Kapodistrian University of Athens, LAIKON General Hospital, Athens, Greece
These authors contributed equally to this manuscript

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Dimitra Melissaridou First Department of Orthopedics, National and Kapodistrian University of Athens, Medical School, ATTIKON University General Hospital, Greece

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Pinelopi Korkolopoulou First Department of Pathology, National and Kapodistrian University of Athens, LAIKON General Hospital, Athens, Greece
Co-senior authors

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Panayiotis J. Papagelopoulos First Department of Orthopedics, National and Kapodistrian University of Athens, Medical School, ATTIKON University General Hospital, Greece
Co-senior authors

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  • Myositis ossificans (MO) is a benign bone formation in an extra-skeletal location. The most common subtype of MO, the post-traumatic, usually develops in young males after a traumatic event or sports injury.

  • MO may simulate malignant bone lesions such as extra-skeletal or surface osteosarcomas, or soft tissue sarcomas such as synovial sarcoma or undifferentiated pleomorphic sarcoma. In the early phase the diagnosis of MO is challenging because imaging and histopathological findings may be non-characteristic.

  • Detailed medical history as well as clinical examination, follow-up imaging studies and histological assessment are crucial for a proper diagnosis. Early and accurate differential diagnosis between MO and malignant soft tissue and bone tumours is important to maximize.

Cite this article: EFORT Open Rev 2021;6:572-583. DOI: 10.1302/2058-5241.6.210002

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Johannes D Bastian Department of Orthopaedic Surgery and Traumatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

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Silviya Ivanova Department of Orthopaedic Surgery and Traumatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

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Ahmed Mabrouk Department of Trauma and Orthopaedics, Leeds Teaching Hospitals NHS Trust, United Kingdom

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Peter Biberthaler Department of Trauma Surgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany

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Pedro Caba-Doussoux Servicio de Cirugía Ortopédica y Traumatología, Hospital 12 de Octubre, Madrid, España

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Nikolaos K Kanakaris Department of Trauma and Orthopaedics, Leeds Teaching Hospitals NHS Trust, United Kingdom
Major Trauma Centre, Leeds Teaching Hospitals NHS Trust, University of Leeds, United Kingdom

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  • Segmental femoral fractures represent a rare but complex clinical challenge. They mostly result from high-energy mechanisms, dictate a careful initial assessment and are managed with various techniques. These often include an initial phase of damage control orthopaedics while the initial manoeuvres of patient and soft tissue resuscitation are employed.

  • Definitive fixation consists of either single-implant (reconstruction femoral nails) or dual-implant constructs. There is no consensus in favour of one of these two strategies.

  • At present, there is no high-quality comparative evidence between the various methods of treatment. The development of advanced design nailing and plating systems has offered fixation constructs with improved characteristics.

  • A comprehensive review of the existing evidence with a step-by-step description of these different definitive fixation strategies based on three case examples was conducted. Furthermore, the rationale for using single vs dual-implant strategy in its case is presented with supportive references.

  • The prevention of complications relies mainly on the strict adherence to basic principles of fracture fixation with an emphasis on careful preoperative planning, the quality of the reduction, and the application of soft tissue-friendly surgical methods.

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Morten Schultz Larsen Department of Orthopaedics and Traumatology, Odense University Hospital, Denmark

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Hagen Schmal Department of Orthopaedics and Traumatology, Odense University Hospital, Denmark

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  • Atypical femoral fractures (AFF) are stress or ‘insufficiency’ fractures, often complicated by the use of bisphosphonates or other bone turnover inhibitors. While these drugs are beneficial for the intact osteoporotic bone, they probably prevent a stress fracture from healing which thus progresses to a complete fracture.

  • Key features of atypical femoral fractures, essential for the diagnosis, are: location in the subtrochanteric region and diaphysis; lack of trauma history and comminution; and a transverse or short oblique configuration.

  • The relative risk of patients developing an atypical femoral fracture when taking bisphosphonates is high; however, the absolute risk of these fractures in patients on bisphosphonates is low, ranging from 3.2 to 50 cases per 100,000 person-years.

  • Treatment strategy in patients with AFF involves: radiograph of the contralateral side (computed tomography and magnetic resonance imaging should also be considered); dietary calcium and vitamin D supplementation should be prescribed following assessment; bisphosphonates or other potent antiresorptive agents should be discontinued; prophylactic surgical treatment of incomplete AFF with cephalomedullary nail, unless pain free; cephalomedullary nailing for surgical fixation of complete fractures; avoidance of gaps in the lateral and anterior cortex; avoidance of varus malreduction.

Cite this article: EFORT Open Rev 2018;3:494-500. DOI: 10.1302/2058-5241.3.170070.

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