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Philippe Hernigou Hôpital Henri Mondor, University Paris East, Paris, France

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Victor Housset Hôpital Henri Mondor, University Paris East, Paris, France

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Jacques Pariat Hôpital Henri Mondor, University Paris East, Paris, France

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Arnaud Dubory Hôpital Henri Mondor, University Paris East, Paris, France

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Charles Henri Flouzat Lachaniette Hôpital Henri Mondor, University Paris East, Paris, France

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infections in THAs related to SCD as compared with other causes of THA. The defective activation of complement’s pathway is facilitated by a non-functioning or absent spleen. This increases the risk of infection by encapsulated bacteria. 8 Therefore

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Sebastian Kopf Center of Orthopaedics and Traumatology, Brandenburg Medical School Theodor Fontane, Germany

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Manuel-Paul Sava Orthopedics and Traumatology 2nd Department, Colentina Clinical Hospital, Bucharest, Romania

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Christian Stärke Department of Orthopaedic Surgery, Otto-von-Guericke University Magdeburg, Germany

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Roland Becker Center of Orthopaedics and Traumatology, Brandenburg Medical School Theodor Fontane, Germany

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system, including the pro-inflammatory pathway. 23 Another definition proposed by the American College of Rheumatic and Therapeutic Criteria states that OA is a group of conditions that are heterogenic, which advances to joint-related symptoms and

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Julie J. Willeumier Department of Orthopaedics, Leiden University Medical Centre, The Netherlands

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Yvette M. van der Linden Department of Orthopaedics, Leiden University Medical Centre, The Netherlands

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Michiel A.J. van de Sande Department of Orthopaedics, Leiden University Medical Centre, The Netherlands

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P.D. Sander Dijkstra Department of Orthopaedics, Leiden University Medical Centre, The Netherlands

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followed: stop; think and stage; act. The most important information is gathered with the following four questions and flowchart ( Fig. 1 ). Fig. 1 Flowchart of diagnostic tests. *Survival prediction according to primary tumour type, patient

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Pedro Cano-Luís Orthopaedic Surgery and Traumatology Department, Hospital Universitario Virgen del Rocío, Spain

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Miguel Ángel Giráldez-Sánchez Orthopaedic Surgery and Traumatology Department, Hospital Universitario Virgen del Rocío, Spain

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Pablo Andrés-Cano Orthopaedic Surgery and Traumatology Department, Hospital Universitario Virgen del Rocío, Spain

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osteotomy is performed with the Gigli saw and introduced through the sciatic notch using the superior window of the ilio-inguinal pathway. We rarely perform osteotomies through the sacrum. Stage 2. In the prone position, a posterior approach is made

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Enrique Gómez-Barrena Servicio de Cirugía Ortopédica y Traumatología, Hospital La Paz-IdiPAZ, Universidad Autónoma de Madrid, Madrid, Spain

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Norma G. Padilla-Eguiluz Servicio de Cirugía Ortopédica y Traumatología, Hospital La Paz-IdiPAZ, Universidad Autónoma de Madrid, Madrid, Spain

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Philippe Rosset Service de Chirurgie Orthopédique et Traumatologie, CHU Tours, Université de Tours, Tours, France

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include decreased local osteogenesis, as concluded by Bajada et al, 27 who demonstrated increased levels of the Wnt signalling inhibitor, DKK1, secreted by cells in the vicinity of the non-union site. This Wnt pathway inhibition could limit BMP

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Alli Gokeler University of Groningen, University Medical Center Groningen, Center for Human Movement Science, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands

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Bart Dingenen Rehabilitation Research Institute, Biomedical Research Institute, Faculty of Medicine and Life Sciences, UHasselt, Diepenbeek, Belgium

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Caroline Mouton Département de l’Appareil Locomoteur, Centre Hospitalier de Luxembourg – Clinique d’Eich, 76, rue d’Eich, L-1460 Luxembourg, Luxembourg

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Romain Seil Département de l’Appareil Locomoteur, Centre Hospitalier de Luxembourg – Clinique d’Eich, 76, rue d’Eich, L-1460 Luxembourg, Luxembourg and Sports Medicine Research Laboratory, Luxembourg Institute of Health, 76, rue d’Eich, L-1460 Luxembourg, Luxembourg

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pathways may be established in individual hospitals or clinics to monitor patients after ACL injury, adapt the care to their individual needs and enhance successful RTS. 11 The work presented in this narrative review is the result of an international

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Lars B. Dahlin Department of Translational Medicine - Hand Surgery, Lund University, and Skåne University Hospital, Malmö, Sweden

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Mikael Wiberg Department of Surgical and Perioperative Science, University Hospital, and Department of Integrative Medical Biology, Umeå University, Sweden

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purpose to create an optimal milieu for the axonal outgrowth after the injury. The proliferation of Schwann cells, forming an optimal pathway for the outgrowing axons, is accompanied by upregulation of a large number of different trophic factors in the

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Dongmei Wu School of Medicine, University of St. Andrews, St. Andrews, Fife, United Kingdom

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Rohan M Bhalekar ExplantLab, The Biosphere, Newcastle Helix, Newcastle-upon-Tyne, United Kingdom

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Jordan S Marsh School of Medicine, University of St. Andrews, St. Andrews, Fife, United Kingdom

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David J Langton ExplantLab, The Biosphere, Newcastle Helix, Newcastle-upon-Tyne, United Kingdom

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Alan J Stewart School of Medicine, University of St. Andrews, St. Andrews, Fife, United Kingdom

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in blood ( 79 , 80 ). It is reported to be a rare complication with a prevalence of around 5% in MoM hip replacements ( 79 ). However, it cannot be used as a diagnostic terminology to define implant failure as it fails to distinguish the complexity

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Ippokratis Pountos Academic Department of Trauma & Orthopaedics, School of Medicine, University of Leeds, UK

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Peter V. Giannoudis Academic Department of Trauma & Orthopaedics, School of Medicine, University of Leeds, and NIHR Leeds Biomedical Research Unit, Chapel Allerton Hospital, LS7 4SA Leeds, West Yorkshire, Leeds, UK

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oblique views, are the primary diagnostic tools. CT scanning has an essential role in the diagnosis and pre-operative planning of these injuries as it provides additional details on the fracture configuration and the exact area of impaction. 28 The

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Djandan Tadum Arthur Vithran Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China

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Anko Elijah Essien Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, China

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Masoud Rahmati Research Centre on Health Services and Quality of Life, Aix Marseille University, Marseille, France
Department of Physical Education and Sport Sciences, Faculty of Literature and Human Sciences, Lorestan University, Khoramabad, Iran
Department of Physical Education and Sport Sciences, Faculty of Literature and Humanities, Vali-E-Asr University of Rafsanjan, Rafsanjan, Iran

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Michael Opoku Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, China

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Dong Keon Yon Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, Republic of Korea
Department of Pediatrics, Kyung Hee University College of Medicine, Seoul, Republic of Korea

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Guillermo F López Sánchez Division of Preventive Medicine and Public Health, Department of Public Health Sciences, School of Medicine, University of Murcia, Murcia, Spain

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Ai Koyanagi Research and Development Unit, Parc Sanitari Sant Joan de Deu, Barcelona, Spain

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Lee Smith Centre for Health, Performance, and Wellbeing, Anglia Ruskin University, Cambridge, UK

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Jae Il Shin Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea

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Wenfeng Xiao Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China

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Shuguang Liu Department of Joint Surgery, Honghui Hospital, Xi’an Jiaotong University, Xi’an, Shaanxi, China

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Yusheng Li Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China

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incidence: a population-based study over 20 years . Journal of Bone and Mineral Research 2014 29 581 – 589 . ( https://doi.org/10.1002/jbmr.2072 ) 39 Plotkin LI & Bellido T . Osteocytic signalling pathways as therapeutic targets for bone fragility

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