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Maria Anna Smolle Department of Orthopaedics and Trauma, Medical University of Graz, Graz, Austria

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Lukas Leitner Department of Orthopaedics and Trauma, Medical University of Graz, Graz, Austria

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Nikolaus Böhler Department for Orthopedics and Traumatology, Kepler University Hospital GmbH, Linz, Austria

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Franz-Josef Seibert Department of Orthopaedics and Trauma, Medical University of Graz, Graz, Austria

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Mathias Glehr Department of Orthopaedics and Trauma, Medical University of Graz, Graz, Austria

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Andreas Leithner Department of Orthopaedics and Trauma, Medical University of Graz, Graz, Austria

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negative impact of smoking regarding various outcome parameters in orthopaedics and trauma, including incidence of fracture, risk for lateral epicondylitis, fracture nonunion and postoperative complication rate. 15 – 18 The aim of the current systematic

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Sohail Nisar Leeds Institute of Rheumatic and Musculoskeletal Medicine, UK
Academic Department of Trauma and Orthopaedics, LGI, University of Leeds, Leeds, UK
Leeds Teaching Hospitals Trust, UK

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Jeya Palan Leeds Teaching Hospitals Trust, UK

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Charles Rivière MSK Lab - Imperial College London, White City Campus, London, UK
The Lister Hospital, Chelsea Bridge, London, UK
Centre de l’Arthrose - Clinique du Sport, Bordeaux-Mérignac, France

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Mark Emerton Leeds Teaching Hospitals Trust, UK

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Hemant Pandit Leeds Institute of Rheumatic and Musculoskeletal Medicine, UK
Leeds Teaching Hospitals Trust, UK

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M Vendittoli P-A . The impact of mechanical and restricted kinematic alignment on knee anatomy in total knee arthroplasty . J Arthroplasty 2017 ; 32 : 2133 – 2140 . 14. Jacobs CA Christensen CP

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Dominic Davenport Department of Trauma & Orthopaedics, Princess Royal University Hospital & King’s College Hospital, UK

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Venu Kavarthapu Department of Trauma & Orthopaedics, Princess Royal University Hospital & King’s College Hospital, UK

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have shown that THA provides improved ‘quality of life’ scores, but there remains the burden of complications which account for 15% of £1bn NHS liability payouts. 2 DaPalma et al analysed the financial impact of complications following hip

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Miguel Relvas-Silva Department of Orthopaedics and Traumatology, São João Universitary Hospital Centre, Porto, Portugal
NeuroGen Research Group, Center for Health Technology and Services Research (CINTESIS), Rua Dr. Plácido da Costa, Porto, Portugal

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Bernardo Sousa Pinto MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences Faculty of Medicine, University of Porto, Porto, Portugal
CINTESIS@RISE - Health Research Network, MEDCIDS, Faculty of Medicine, University of Porto, Porto, Portugal

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António Sousa Department of Orthopaedics and Traumatology, São João Universitary Hospital Centre, Porto, Portugal

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Miguel Loureiro Department of Orthopaedics and Traumatology, São João Universitary Hospital Centre, Porto, Portugal
Hospital das Forças Armadas, Porto, Portugal

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André Rodrigues Pinho Department of Orthopaedics and Traumatology, São João Universitary Hospital Centre, Porto, Portugal
Unit of Anatomy, Department of Biomedicine, Faculty of Medicine, University of Porto, Alameda Professor Hernâni Monteiro, Porto, Portugal

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Pedro Pereira NeuroGen Research Group, Center for Health Technology and Services Research (CINTESIS), Rua Dr. Plácido da Costa, Porto, Portugal
CINTESIS@RISE - Health Research Network, MEDCIDS, Faculty of Medicine, University of Porto, Porto, Portugal
Unit of Anatomy, Department of Biomedicine, Faculty of Medicine, University of Porto, Alameda Professor Hernâni Monteiro, Porto, Portugal

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250 million individuals ( 1 , 2 ). LDD can present with varying symptoms and severity, remaining one of the most relevant causes of disability and work absenteeism due to its substantial impact on patient’s quality of life ( 3 ). Treatment

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Valentina Viglione Clinica Ortopedica e Traumatologica 1 IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

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Angelo Boffa Applied and Translational Research (ATR) Center, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

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Davide Previtali Department of Surgery, EOC, Service of Orthopaedics and Traumatology, Lugano, Switzerland

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Francesca Vannini Clinica Ortopedica e Traumatologica 1 IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

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Cesare Faldini Clinica Ortopedica e Traumatologica 1 IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

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Giuseppe Filardo Applied and Translational Research (ATR) Center, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
Department of Surgery, EOC, Service of Orthopaedics and Traumatology, Lugano, Switzerland
Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland

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in randomized controlled trials (RCTs) in comparison to the inactive treatments implying that their effect, or at least a part of it, may be due to placebo ( 6 ). The impact of the placebo effect has been already investigated in several

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Simon A. Hurst Department of Trauma & Orthopaedic Surgery, Imperial College, St Mary’s Hospital Campus, London, UK

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Thomas M. Gregory Department of Trauma & Orthopaedic Surgery, Avicenne Teaching Hospital, University of Paris 13, Bobigny, France
Department of Mechanical Engineering, Imperial College, London, UK

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Peter Reilly Department of Trauma & Orthopaedic Surgery, Imperial College, St Mary’s Hospital Campus, London, UK

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of blunt trauma to the region, such as might occur following direct impact to the shoulder region when tacking another player during a game of American football. 19 Diagnosis Patients often present with non-specific symptoms. These can

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Elizabeth K Tissingh The Bone Infection Unit, Nuffield Orthopaedic Centre, Oxford University Hospitals, Oxford, UK
King’s Global Health Partnerships, School of Life Course and Population Sciences, King’s College London, London, UK

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Leonard Marais Department of Orthopaedic Surgery, School of Clinical Medicine, University of KwaZulu-Natal, KwaZulu-Natal, South Africa

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Antonio Loro Comprehensive Rehabilitation Services for People with Disability in Uganda (CoRSU) Hospital, Kisubi, Uganda

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Deepa Bose University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK

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Nilo T Paner Department of Orthopaedics, University of the Philippines, Philippine General Hospital Manila, The Phillipines

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Jamie Ferguson The Bone Infection Unit, Nuffield Orthopaedic Centre, Oxford University Hospitals, Oxford, UK
Department of Orthopaedics, University of the Philippines, Philippine General Hospital Manila, The Phillipines

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Mario Morgensten Centre for Musculoskeletal Infections, Department of Orthopaedic and Trauma Surgery, University Hospital Basel, Basel, Switzerland

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Martin McNally The Bone Infection Unit, Nuffield Orthopaedic Centre, Oxford University Hospitals, Oxford, UK

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– such as delays in accessing care, resource constraints, population demographics, pathogen patterns and host comorbidities – may have an impact on how applicable guidelines are to these different contexts. In LMICs where fracture fixation with metalwork

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Michael J Raschke Department of Trauma-, Hand- and Reconstructive Surgery, University Hospital Muenster, Muenster, Germany

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Sabine Ochman Department of Trauma-, Hand- and Reconstructive Surgery, University Hospital Muenster, Muenster, Germany

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Alexander Milstrey Department of Trauma-, Hand- and Reconstructive Surgery, University Hospital Muenster, Muenster, Germany

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  • The relevance of geriatric ankle fractures is continuously increasing.

  • Treatment of these patients remains challenging and requires adapted diagnostic and therapeutic strategies, as compliance to partial weight bearing is difficult to maintain compared to younger patients.

  • In addition, in the elderly even low impact injuries may lead to severe soft tissue trauma, influencing timing and operative strategies.

  • Recently, the direct posterolateral approach and plate fixation techniques, angular stable implants as well as intramedullary nailing of the distal fibula have been found to improve stategical concepts.

  • This article aims to provide a comprehensive overview of the diagnostic and recent aspects with respect to how this difficult entity of injuries should be approached.

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Volkmar Jansson Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, University Hospital of Munich (LMU), Campus Grosshadern, Munich, Germany

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Alexander Grimberg German Arthroplasty Registry (EPRD Deutsche Endoprothesenregister gGmbH), Berlin, Germany

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Oliver Melsheimer German Arthroplasty Registry (EPRD Deutsche Endoprothesenregister gGmbH), Berlin, Germany

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Carsten Perka Charité Center for Orthopedics and Trauma Surgery, Charité University Hospital, Berlin, Germany

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Arnd Steinbrück Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, University Hospital of Munich (LMU), Campus Grosshadern, Munich, Germany
German Arthroplasty Registry (EPRD Deutsche Endoprothesenregister gGmbH), Berlin, Germany

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  • National joint registries are gaining more and more importance in the fields of implant monitoring/outlier detection and quality of care.

  • The German Arthroplasty Registry (EPRD) was established in 2010 for the purpose of observing the impact of primary hip and knee arthroplasty on the German population.

  • Having now over one million documentations, we introduce the structure of the EPRD and detail the process of data collection.

  • We report on some preliminary trends and contrast these with findings from other joint registries.

  • We introduce the overhauled Arthroplasty Library, that resulted from an international collaboration with National Joint Registry of England, Wales and Northern Ireland.

Cite this article: EFORT Open Rev 2019;4 DOI: 10.1302/2058-5241.4.180064

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Catalin Cirstoiu Orthopedics and Traumatology Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Orthopedics and Traumatology Department, University Emergency Hospital Bucharest, Bucharest, Romania

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Bogdan Cretu Orthopedics and Traumatology Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Orthopedics and Traumatology Department, University Emergency Hospital Bucharest, Bucharest, Romania

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Sergiu Iordache Orthopedics and Traumatology Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Orthopedics and Traumatology Department, University Emergency Hospital Bucharest, Bucharest, Romania

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Mihnea Popa Orthopedics and Traumatology Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Orthopedics and Traumatology Department, University Emergency Hospital Bucharest, Bucharest, Romania

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Bogdan Serban Orthopedics and Traumatology Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Orthopedics and Traumatology Department, University Emergency Hospital Bucharest, Bucharest, Romania

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Adrian Cursaru Orthopedics and Traumatology Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Orthopedics and Traumatology Department, University Emergency Hospital Bucharest, Bucharest, Romania

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  • Bone metastases are difficult to treat surgically, necessitating a multidisciplinary approach that must be applied to each patient depending on the specifics of their case.

  • The main indications for surgical treatment are a lack of response to chemotherapy, radiation therapy, hormone therapy, immunotherapy, and bisphosphonates which is defined by persistent pain or tumor progression; the risk of imminent pathological bone fracture; and surgical treatment for single bone metastases.

  • An important aspect of choosing the right treatment for these patients is accurately estimating life expectancy. Improved chemotherapy, postoperative radiation therapy, and sustainable reconstructive modalities will increase the patient’s life expectancy.

  • The surgeon should select the best surgical strategy based on the primary tumor and its characteristics, the presence of single or multiple metastases, age, anatomical location, and the functional resources of the patient.

  • Preventive osteosynthesis, osteosynthesis to stabilize a fracture, resections, and reconstructions are the main surgical options for bone metastases.

  • Resection and reconstruction with a modular prosthesis remain the generally approved surgical option to restore functionality, increase the quality of life, and increase life expectancy.

  • Preoperative embolization is necessary, especially in the case of metastases of renal or thyroid origin. This procedure is extremely important to avoid complications, with a major impact on survival rates.

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