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Surgical Department - Hand Surgery Unit EOC, Locarno's Regional Hospital, Locarno, Switzerland
Locarno Hand Center, Locarno, Switzerland
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Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland
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Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland
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randomized controlled trials (RCTs) comparing VLP vs cast for the treatment of DRFs in adults, written in English language. Case reports or case series describing less than or equal to five cases and non-comparative articles were excluded. Pre-clinical and
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-reported, subjective scales (e.g. pain), radiographic analysis, failure rates; randomized controlled trials, cohort studies, case series (with greater than 10 patients); mean follow up of at least 12 months. The exclusion criteria were: case reports; case series with
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score is out of a maximum of 10 points, except for randomized controlled trials which have a maximum score of 13 and are clearly labelled. Table 3. Numerical summary of the Cierny–Mader grade of patients in studies where this information was
Department of Pharmaceutical, Lanzhou University Second Hospital, Lanzhou, Gansu province, P.R. China
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standard treatment, while the control group may receive a placebo or standard care regimen; (iii) the design of included studies should be randomized controlled trials (RCTs), cohort studies (prospective or retrospective); (iv) patients were with
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review. Mean follow-up time was 21.1 months and mean age of included patients was 40.0 years. Description of studies and demographic characteristics of patients analysed are displayed in Table 1 . No randomized control trails (RCTs) were identified in
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Department of Surgery, EOC, Service of Orthopaedics and Traumatology, Lugano, Switzerland
Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland
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in randomized controlled trials (RCTs) in comparison to the inactive treatments implying that their effect, or at least a part of it, may be due to placebo ( 6 ). The impact of the placebo effect has been already investigated in several
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(Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The protocol for this meta-analysis was registered on PROSPERO (Registration No: CRD 42023459675). Inclusion criteria Study type: randomized controlled trial or cohort
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trial . Lancet 2010 ; 376 : 1085 - 1092 . 19 Farrokhi MR , Alibai E , Maghami Z . Randomized controlled trial of percutaneous vertebroplasty versus optimal medical management for the relief of pain and disability in
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continues. 36 Clinical equipoise drives many randomized controlled trials, a scenario of uncertainty that surgeons often find difficult to manage. This may be due to personal beliefs, previous experience or opinions. 35 For similar reasons
CETAPS UR3832, Research Center for Sports and Athletic Activities Transformations, University of Rouen Normandy, Mont-Saint-Aignan, France
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evidence; PS, prospective study; RS, retrospective study. Quality assessment Of the five eligible studies, one was a randomized controlled trial and four were case series. Statistical analyses were insufficient in two of the five studies, as