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Christoph H. Lohmann Department of Orthopeadic Surgery, Otto-von-Guericke University, Leipziger Str. 44,39120 Magdeburg, Germany

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Sanjiv Rampal Department of Orthopeadic Surgery, Otto-von-Guericke University, Leipziger Str. 44,39120 Magdeburg, Germany

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Martin Lohrengel Department of Orthopeadic Surgery, Otto-von-Guericke University, Leipziger Str. 44,39120 Magdeburg, Germany

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Gurpal Singh Division of Musculoskeletal Oncology, University Orthopaedics Hand and Reconstructive Microsurgery Cluster, National University Health System, 1E Kent Ridge Road, 119228 Singapore

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(SEMAC), has been reported as favourable in the presences of metal implants. 3 – 6 Compared with conventional MRI however, MARS-MRI is more time-consuming and image quality is inferior due to reduced resolution and signal-to-noise ratio. 7

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Hua Luo Department of Orthopedics, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Congcong He Department of Psychology, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Yong Zhao Department of Orthopedics, Shanghai Fengxian District Central Hospital, Shanghai, China

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Guangyong Yang Department of Orthopedics, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Hainan Hong Department of Orthopedics, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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reported rates as high as 1%, and the long-term risk of periprosthetic joint infection (PJI) is elevated, reaching 6% at 15 years (approximately six times higher than the general population) ( 3 , 9 ). In cases where SA does not resolve or when joint

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Di Zhao The Second Clinical School of Guangzhou University of Chinese Medicine, Guangzhou, China
Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China

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Ling-feng Zeng The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China

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Gui-hong Liang The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China

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Jian-ke Pan The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China

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Ming-hui Luo The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China

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Yan-hong Han The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China

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Jun Liu Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China
Guangdong Second Traditional Chinese Medicine Hospital (Guangdong Province Engineering Technology Research Institute of Traditional Chinese Medicine), Guangzhou, China
The fifth Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, China

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Wei-yi Yang The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China

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perspectives on risks and benefits. In terms of abnormal peripheral sensation, more than half of the RCTs reported a higher incidence with anti-NGF monoclonal antibody treatment. However, most of these cases are short-term without any permanent sequelae

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Sylvain Steinmetz Service of Orthopaedics and Traumatology, Lausanne University Hospital, Lausanne, Switzerland

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Diane Wernly Service of Orthopaedics and Traumatology, Lausanne University Hospital, Lausanne, Switzerland

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Kevin Moerenhout Service of Orthopaedics and Traumatology, Lausanne University Hospital, Lausanne, Switzerland

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Andrej Trampuz Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery (CMSC), Berlin, Germany

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Olivier Borens Service of Orthopaedics and Traumatology, Lausanne University Hospital, Lausanne, Switzerland

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an important socio-economic burden. 2 The success rate in the treatment of IAFF is between 70% and 90%. 3 Some studies report an incidence of IAFF for closed fractures of 1% to 2% with an incidence even reaching up to 30% in open fractures

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Jean-Charles Aurégan Department of Orthopaedic, Trauma and Reconstructive Surgery, Antoine Béclère Hospital, AP-HP, Paris Sud University, France.
Laboratory of Tribology and System Dynamics, Ecole Centrale Lyon, France.
Laboratory of Bioengineering and Bioimagery for Bone and Articulation, Paris-Diderot University, France.

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Catherine Bosser Laboratory of Tribology and System Dynamics, Ecole Centrale Lyon, France.

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Morad Bensidhoum Laboratory of Bioengineering and Bioimagery for Bone and Articulation, Paris-Diderot University, France.

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Thierry Bégué Department of Orthopaedic, Trauma and Reconstructive Surgery, Antoine Béclère Hospital, AP-HP, Paris Sud University, France.

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Thierry Hoc Laboratory of Tribology and System Dynamics, Ecole Centrale Lyon, France.

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connections between skin and bone tissues could exist. In 1963, McConkey et al reported that elderly women with osteoporotic fractures had a higher incidence of thin skin. 8 Later, Black et al confirmed the simultaneous occurrence of these events by

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Razvan Ene Carol Davila University of Medicine and Pharmacy, Orthopedics and Traumatology Department, Bucharest, Romania
Bucharest Emergency Clinical Hospital, Romania

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Mihai Nica Carol Davila University of Medicine and Pharmacy, Orthopedics and Traumatology Department, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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Dragos Ene Carol Davila University of Medicine and Pharmacy, Orthopedics and Traumatology Department, Bucharest, Romania
Bucharest Emergency Clinical Hospital, Romania

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Adrian Cursaru Carol Davila University of Medicine and Pharmacy, Orthopedics and Traumatology Department, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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Catalin Cirstoiu Carol Davila University of Medicine and Pharmacy, Orthopedics and Traumatology Department, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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. 56 The only other study focused on assessment of only septic revision procedures augmented with local antibiotic delivery by CS beads was Kallala et al 2015, with a reported rate of 6.7% reinfection but a small number of cases (15 patients). 57

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T. Fintan Moriarty AO Research Institute Davos, Switzerland

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Richard Kuehl University Hospital of Basel, Switzerland

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Tom Coenye Ghent University, Belgium

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Willem-Jan Metsemakers University Hospitals Leuven, Belgium

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Mario Morgenstern Trauma Centre, Murnau, Germany

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Edward M. Schwarz University of Rochester Medical Center, New York, USA

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Martijn Riool AMC, University of Amsterdam, The Netherlands

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Sebastian A.J. Zaat AMC, University of Amsterdam, The Netherlands

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Nina Khana University Hospital of Basel, Switzerland

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Stephen L. Kates Virginia Commonwealth University, Virginia, USA

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R. Geoff Richards AO Research Institute Davos, Switzerland

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skin and eyes due to silver deposition called argyria and argyrosis, respectively. 123 - 125 Nevertheless, few case reports exist of neural or other systemic toxicity after high exposure to silver. 126 , 127 In this context, the potent new

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Chengxin Xie Department of Orthopedics, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Liwei Zhang Department of Orthopedics, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Dehua Zhang Department of Emergency, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Lingjian Tao Department of Orthopedics, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Yong Zhao Department of Orthopedics, Shanghai Fengxian District Central Hospital, Shanghai 201400, China.

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Hua Luo Department of Orthopedics, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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criteria Letters, case reports, reviews, animal trials, or republished studies; unused vancomycin in the treatment group; previous joint infections; studies lacking a control group. Outcomes The primary outcome was the incidence of SSI. Secondary

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Anne Lübbeke Division of Orthopaedic Surgery and Traumatology, Geneva University Hospitals, Switzerland; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, UK

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): enhancing decision making and follow-up . BMJ Case Rep 2017 ; 2017 :bcr-2017-221172. 48. Kwong E Black N . Retrospectively patient-reported pre-event health status showed strong association and agreement with contemporaneous

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Alan G. Fraser Department of Cardiology, University Hospital of Wales, Cardiff, UK

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Rob G.H.H. Nelissen Department of Orthopaedics, Leiden University Medical Center, Leiden, Netherlands

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Per Kjærsgaard-Andersen Department of Orthopaedics, Vejle Hospital, South Danish University, Vejle, Denmark

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Piotr Szymański Centre of Postgraduate Medical Education, MSWiA Central Clinical Hospital, Warsaw, Poland

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Tom Melvin Healthcare Products Regulatory Authority, Earlsfort Terrace, Dublin 2, Ireland

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Paul Piscoi Health Technology Unit B6, Directorate General for Health (DG SANTE), European Commission, Brussels, Belgium

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On behalf of the CORE–MD Investigators (see Appendix) Alan Fraser, Piotr Szymański, Chris Gale, Aldo Maggioni, Elisabetta Zanon, Christina Dimopoulou, Cinzia Ceccarelli, Polyxeni Vairami, Anett Ruszanov, Per Kjærsgaard-Andersen, Rob Nelissen, Adrian Ott, Elizabeth Macintyre, Loredana Simulescu, Marieke Meijer, Berthold Koletzko, Sarah Wieczorek, Adamos Hadjipanayis, Stefano Del Torso, Perla Marang-van de Mheen, Lotje Hoogervorst, Ewout W. Steyerberg, Bas Penning De Vries, Peter McCulloch, Martin Landray, Daniel Prieto Alhambra, James Smith, Anne Lubbeke-Wolf, Stefan James, Sergio Buccheri, Robert Byrne, Laurna McGovern, Stephan Windecker, Andre Frenk, Georgios Siontis, Christoph Stettler, Arjola Bano, Lia Bally, Frank E. Rademakers, Jan D‘hooge, Anton Vedder, Elisabetta Biasin, Erik Kamenjasevic, Petra Schnell-Inderst, Felicitas Kühne, Ola Rolfson, Joel Jakobsson, Amanda Tornsö, Enrico G. Caiani, Lorenzo Gianquintieri, Cinzia Cappiello, Maristella Matera, Tom Melvin, Niall MacAleenan, Ria Mahon, Michèle Meagher, Gearóid McGauran, Thomas Wejs Møller, Ann-Sofie Sonne Holm-Schou, Jan Szulc, Robert E. Geertsma, Jantine W.P.M. van Baal, Joëlle M. Hoebert, Susana L.F. Cabaço, Paola Laricchiuta, Marina Torre, Filippo Boniforti, Eugenio Carrani, Stefania Ceccarelli, Claudia Wild, Sabine Ettinger, Juan Antonio Blasco Amaro, Juan Carlos Rejón Parrilla, Agnieszka Dobrzynska, David Epstein, Valentina Strammiello, Hannes Jarke, Kaisa Immonen, Françoise Schlemmer, Sabina Hoekstra, Marianna Mastroroberto, Christoph Ziskoven, Michael Hahn, Erman Melikyan, Richard Holborow, Suzanne Halliday, Alexey Shiryaev, Gero Viola, Harry van Vugt

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(cohort, registry-based cohort, case-control, randomised controlled trial (RCT), case series or reports) and annual reports from national registries will be evaluated, to obtain insights into descriptive data and revision rate estimates. For diabetic

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