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monitoring of a patient treated with a VKA. 36 , 38 , 39 A therapeutic INR range of 2.0 to 3.0 with a target INR of 2.5 is recommended rather than a lower or higher range. It is suggested that INR monitoring should start after the initial two or three
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Applied and Translational Research Center, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
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another important element to be considered for the direct implications in anaesthesia-related risks and costs. 43 Due to the lack of data of the retrieved studies about the cost aspect, we did not perform a specific economic analysis on costs between
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latter subunit, the final complex ultimately will function to regulate target genes such as vascular endothelial growth factor and cathepsin D. Possible therapeutic intervention points are: the hydroxylation that leads to degradation of HIF-1α, the
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pharmacological responses to a therapeutic intervention’. 19 Biomarkers are especially useful as surrogates for clinical outcomes that are rare or occur very late (e.g. revision of joint replacement, mortality). According to Rigatto and Barret 18 ‘a
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patient’s quality of life. The diagnostic evaluation of a suspicious spinal secondary lesion contains some recently developed steps which are major cornerstones of the therapeutic planning. The indication for surgery is a key issue and it is strongly
Health Sciences PhD Program, Universidad Católica de Murcia UCAM, Murcia, Spain
Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA
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an efficient reduction in patient recovery times demands the full integration of the entire medical team and the implementation of highly specific therapeutic approaches. A key strategy is to enhance diagnostic capability, as increasing precision
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of 46 cases . Cancer 1999 ; 85 : 1044 – 1054 . 11. Nouri H Ben Maitigue M Abid L et al. Surface osteosarcoma: clinical features and therapeutic implications . J Bone Oncol 2015 ; 4 : 115 – 123 . 12. Gholamrezanezhad
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attended fracture clinics at regular fixed periods, the modern emphasis is to attend only when and where necessary, to reduce therapeutic inertia. During the COVID-19 pandemic, the aim is to reduce face-to-face appointments, therefore a safe alternative
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Clin Orthop Trauma 2013 ; 4 : 157 – 163 . 24. Khanna G Cernovsky J . Bone cement and the implications for anaesthesia . Contin Educ Anaesth Crit Care Pain 2017 ; 12 : 213 – 216 . 25. Gallo J
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based on their action on bone remodeling . J Bone Miner Res 2005 ; 20 : 177 – 184 . 8. Kennel KA Drake MT . Adverse effects of bisphosphonates: implications for osteoporosis management . Mayo Clin Proc 2009 ; 84 : 632
