T. Fintan Moriarty
T. Fintan Moriarty
AO Research Institute Davos, Switzerland
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Richard Kuehl
Richard Kuehl
University Hospital of Basel, Switzerland
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Tom Coenye
Tom Coenye
Ghent University, Belgium
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Willem-Jan Metsemakers
Willem-Jan Metsemakers
University Hospitals Leuven, Belgium
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Mario Morgenstern
Mario Morgenstern
Trauma Centre, Murnau, Germany
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Edward M. Schwarz
Edward M. Schwarz
University of Rochester Medical Center, New York, USA
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Martijn Riool
Martijn Riool
AMC, University of Amsterdam, The Netherlands
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Sebastian A.J. Zaat
Sebastian A.J. Zaat
AMC, University of Amsterdam, The Netherlands
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Nina Khana
Nina Khana
University Hospital of Basel, Switzerland
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Stephen L. Kates
Stephen L. Kates
Virginia Commonwealth University, Virginia, USA
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R. Geoff Richards
R. Geoff Richards
AO Research Institute Davos, Switzerland
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specific application in the most challenging cases • Outlook : Role in antibiotic-resistant cases, or for coverage of multiple species • Numerous clinical trials ongoing • To date, no trial shown efficacy in terms of reduced incidence • Outlook : Great
Giorgio Maria Calori
Giorgio Maria Calori
ASST-Pini-CTO, University of Milan, Orthopaedic Reparative Surgery Department, Milan, Italy
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Emilio Mazza
Emilio Mazza
ASST-Pini-CTO, University of Milan, Orthopaedic Reparative Surgery Department, Milan, Italy
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Alessandra Colombo
Alessandra Colombo
ASST-Pini-CTO, University of Milan, Orthopaedic Reparative Surgery Department, Milan, Italy
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Simone Mazzola
Simone Mazzola
ASST-Pini-CTO, University of Milan, Orthopaedic Reparative Surgery Department, Milan, Italy
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Massimiliano Colombo
Massimiliano Colombo
ASST-Pini-CTO, University of Milan, Orthopaedic Reparative Surgery Department, Milan, Italy
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reported the results of a five-year follow-up of a prospective controlled study of the efficacy of bone marrow cells implantation into the necrotic lesion of the FH on clinical symptoms and the progression of AVN in comparison with CD. They studied 19
Mustafa S. Rashid
Mustafa S. Rashid
Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences (NDORMS), University of Oxford, Oxford, UK
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Yves Tourné
Yves Tourné
Institut Grenoblois de Chirurgie du Pied, Echirolles, France
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Kar H. Teoh
Kar H. Teoh
Princess Alexandra Hospital, Harlow, UK
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clinical efficacy and clinical effectiveness of LIPUS therapy in the foot and ankle exist. A clinical efficacy study investigating the use of LIPUS therapy in a particular area, such as delayed unions in 5th metatarsal fractures, may utilize a double
Andrew J Harrison
Andrew J Harrison
Bioventus International, Taurusavenue, Hoofddorp, Netherlands
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Michael R Redler
Michael R Redler
Connecticut Orthopaedics, Department of Orthopaedics, University of Virginia, Frank H. Netter School of Medicine, Quinnipiac University, USA
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David M Taylor
David M Taylor
Leeds General Infirmary, Leeds, UK
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Ansar Mahmood
Ansar Mahmood
Department Trauma & Orthopaedic Surgery, Queen Elizabeth Hospital, Birmingham, UK
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John T Jones
John T Jones
Statistician - Raleigh, NC
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Yukihiro Arai
Yukihiro Arai
Department of Orthopaedic Surgery, Teikyo University School of Medicine
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Yoshinobu Watanabe
Yoshinobu Watanabe
Department of Orthopaedic Surgery, Teikyo University School of Medicine
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respond to LIPUS to achieve consolidation. The impact of the surgeon/physician on the efficacy of LIPUS Over the 25 years that the LIPUS has been in widespread clinical use, a large volume of evidence has been collected to support its efficacy and
Yvet Mooiweer
Yvet Mooiweer
Department of Health Services Research, Carl von Ossietzky University, Oldenburg, Germany
Department of Orthopedics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
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Department of Orthopedics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
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Lina Roling
Lina Roling
School of Medicine and Health Sciences, Carl von Ossietzky University, Oldenburg, Germany
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Margaret Vugrin
Margaret Vugrin
Preston Smith Library, Texas Tech University Health Sciences Center, Lobbock, Texas, USA
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Lena Ansmann
Lena Ansmann
Department of Health Services Research, Carl von Ossietzky University, Oldenburg, Germany
Chair of Medical Sociology, Institute of Medical Sociology, Health Services Research and Rehabilitation Science (IMVR) Faculty of Medicine, University of Cologne, Oldenburg, Germany
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Chair of Medical Sociology, Institute of Medical Sociology, Health Services Research and Rehabilitation Science (IMVR) Faculty of Medicine, University of Cologne, Oldenburg, Germany
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Martin Stevens
Martin Stevens
Department of Orthopedics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
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Gesine H Seeber
Gesine H Seeber
Department of Orthopedics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
University Hospital of Orthopedics and Trauma Surgery Pius-Hospital, Medical Campus University of Oldenburg, Oldenburg, Germany
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University Hospital of Orthopedics and Trauma Surgery Pius-Hospital, Medical Campus University of Oldenburg, Oldenburg, Germany
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distinguish them from expectations). The rationale for their study was based on the self-efficacy concept and the placebo effect. Self-efficacy is a central aspect of Bandura’s social cognitive theory. Bandura describes self-efficacy as the perceived
Anne Lübbeke
Anne Lübbeke
Division of Orthopaedic Surgery and Traumatology, Geneva University Hospitals, Switzerland; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, UK
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crucial to include both safety and efficacy (= ability to produce an expected result under ideal circumstances)/effectiveness (= ability to produce an expected result in the real-world clinical setting) or in other words benefit and harm of a health
Daniel J. McCormack
Daniel J. McCormack
Department of Orthopaedics, University Hospitals of Leicester NHS Trust, Leicester, UK
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Darren Puttock
Darren Puttock
Department of Orthopaedics, University Hospitals of Leicester NHS Trust, Leicester, UK
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Steven P. Godsiff
Steven P. Godsiff
Department of Orthopaedics, University Hospitals of Leicester NHS Trust, Leicester, UK
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of choice would be a total knee arthroplasty; however, this involves removing healthy joint surfaces. Arthroscopic debridement in the osteoarthritic knee has fallen out of favour due to poor clinical results. 1 Recently, a trend has developed
Qiuyuan Wang
Qiuyuan Wang
Department of Evidence-based Medicine, Luoyang Orthopedic Hospital of Henan Province. Orthopedic Hospital of Henan Province, Luoyang, China
Department of Bone And Joint Diseases, Luoyang Orthopedic Hospital of Henan Province. Orthopedic Hospital of Henan Province, Luoyang, China
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Department of Bone And Joint Diseases, Luoyang Orthopedic Hospital of Henan Province. Orthopedic Hospital of Henan Province, Luoyang, China
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Feng Li
Feng Li
Department of Bone And Joint Diseases, Luoyang Orthopedic Hospital of Henan Province. Orthopedic Hospital of Henan Province, Luoyang, China
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Yidan Yang
Yidan Yang
Department of Evidence-based Medicine, Luoyang Orthopedic Hospital of Henan Province. Orthopedic Hospital of Henan Province, Luoyang, China
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Chen Yue
Chen Yue
Department of Evidence-based Medicine, Luoyang Orthopedic Hospital of Henan Province. Orthopedic Hospital of Henan Province, Luoyang, China
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Jiayi Guo
Jiayi Guo
Department of Evidence-based Medicine, Luoyang Orthopedic Hospital of Henan Province. Orthopedic Hospital of Henan Province, Luoyang, China
Department of Bone And Joint Diseases, Luoyang Orthopedic Hospital of Henan Province. Orthopedic Hospital of Henan Province, Luoyang, China
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Department of Bone And Joint Diseases, Luoyang Orthopedic Hospital of Henan Province. Orthopedic Hospital of Henan Province, Luoyang, China
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opioid consumption: a prospective randomized controlled trial . Clinical Journal of Pain 2022 38 388 – 395 . ( https://doi.org/10.1097/AJP.0000000000001036 ) 12 Wang Q Zhao C Hu J Ma T Yang J & Kang P . Efficacy of a modified cocktail
Hua Luo
Hua Luo
Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China
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Xueli Yan
Xueli Yan
Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China
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Yu Ren
Yu Ren
Department of Pharmacy, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China
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Han Zhang
Han Zhang
Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China
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Wenjun Pan
Wenjun Pan
Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China
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.1016/j.spinee.2021.06.009 ) 3. Sun WX Liu HN Chen MT Lin YP Wang HS & Chen BL . Meta-analysis of the clinical efficacy and safety of oblique lateral interbody fusion and transforaminal interbody fusion in the treatment of degenerative
Tobias Winkler
Tobias Winkler
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
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Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
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Sven Geissler
Sven Geissler
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
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Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
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Tazio Maleitzke
Tazio Maleitzke
Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
Trauma Orthopaedic Research Copenhagen Hvidovre (TORCH), Department of Orthopaedic Surgery, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
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Trauma Orthopaedic Research Copenhagen Hvidovre (TORCH), Department of Orthopaedic Surgery, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
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Carsten Perka
Carsten Perka
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
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Georg N Duda
Georg N Duda
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
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Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
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Alexander Hildebrandt
Alexander Hildebrandt
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
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Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
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, the mechanism of action for biological drugs and biomaterials and the regulatory requirements for advanced biological products are necessary to design a targeted drug that has a chance to show clinically relevant efficacy in a randomized, placebo
