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Yvet Mooiweer Department of Health Services Research, Carl von Ossietzky University, Oldenburg, Germany
Department of Orthopedics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

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Lina Roling School of Medicine and Health Sciences, Carl von Ossietzky University, Oldenburg, Germany

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Margaret Vugrin Preston Smith Library, Texas Tech University Health Sciences Center, Lobbock, Texas, USA

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Lena Ansmann Department of Health Services Research, Carl von Ossietzky University, Oldenburg, Germany
Chair of Medical Sociology, Institute of Medical Sociology, Health Services Research and Rehabilitation Science (IMVR) Faculty of Medicine, University of Cologne, Oldenburg, Germany

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Martin Stevens Department of Orthopedics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

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Gesine H Seeber Department of Orthopedics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
University Hospital of Orthopedics and Trauma Surgery Pius-Hospital, Medical Campus University of Oldenburg, Oldenburg, Germany

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outcomes. Postoperative: overall outcome, pain, function, stiffness, satisfaction, and/or quality of life Comparison NA NA Study design Prospective longitudinal cohort study Retrospective studies, case reports, commentaries

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E. Carlos Rodríguez-Merchán Department of Orthopaedic Surgery, La Paz University Hospital-IdiPaz, Madrid, Spain

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limited to small case series and case reports. Research has found that, while pain alleviation and patient satisfaction are promising, variable results with significant complications and infection rates may discourage routine use of TER for haemophilic

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Christof Berberich Department of Medical Training and Education, Heraeus Medical GmbH, Wehrheim, Germany

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Pablo Sanz-Ruiz Department of Traumatology and Orthopaedic Surgery, General University Hospital Gregorio Marañón, Madrid, Spain

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one hand, Hope et al reported that the number of PJI cases caused by gentamicin-resistant coagulase-negative Staphylococci increased with prior exposure to antibiotic-loaded bone cement (gentamicin resistance found in 30% of all 91 PJI cases). 37

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Stavros Tsotsolis Academic Orthopaedic Department, Aristotle University Medical School, General Hospital Papageorgiou, Ring Road Efkarpia, Thessaloniki, Greece
Centre of Orthopaedic and Regenerative Medicine (CORE), Center for Interdisciplinary Research and Innovation (CIRI)-Aristotle University of Thessaloniki (AUTH), Balkan Center, Buildings A & B, Thessaloniki, Greece
Trauma and Orthopaedics Department, Guy’s and St Thomas’ NHS Foundation Trust, London, UK

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Eustathios Kenanidis Academic Orthopaedic Department, Aristotle University Medical School, General Hospital Papageorgiou, Ring Road Efkarpia, Thessaloniki, Greece
Centre of Orthopaedic and Regenerative Medicine (CORE), Center for Interdisciplinary Research and Innovation (CIRI)-Aristotle University of Thessaloniki (AUTH), Balkan Center, Buildings A & B, Thessaloniki, Greece

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Vasileios F Pegios Academic Orthopaedic Department, Aristotle University Medical School, General Hospital Papageorgiou, Ring Road Efkarpia, Thessaloniki, Greece
Centre of Orthopaedic and Regenerative Medicine (CORE), Center for Interdisciplinary Research and Innovation (CIRI)-Aristotle University of Thessaloniki (AUTH), Balkan Center, Buildings A & B, Thessaloniki, Greece

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Michael Potoupnis Academic Orthopaedic Department, Aristotle University Medical School, General Hospital Papageorgiou, Ring Road Efkarpia, Thessaloniki, Greece
Centre of Orthopaedic and Regenerative Medicine (CORE), Center for Interdisciplinary Research and Innovation (CIRI)-Aristotle University of Thessaloniki (AUTH), Balkan Center, Buildings A & B, Thessaloniki, Greece

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Eleftherios Tsiridis Academic Orthopaedic Department, Aristotle University Medical School, General Hospital Papageorgiou, Ring Road Efkarpia, Thessaloniki, Greece
Centre of Orthopaedic and Regenerative Medicine (CORE), Center for Interdisciplinary Research and Innovation (CIRI)-Aristotle University of Thessaloniki (AUTH), Balkan Center, Buildings A & B, Thessaloniki, Greece

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combination of the abovementioned ‘Mesh’ terms during our search strategy. Randomized control and case-control studies, cohort and observational clinical studies were included. Case reports, letters to the editor or editorial comments, reviews, animal or

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A Frodl Department of Orthopedics and Traumatology, Freiburg University Hospital, Freiburg, Germany

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N Geisteuer Department of Orthopedics and Traumatology, Asklepios Hospital Harburg, Hamburg, Germany

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A Fuchs Department of Orthopedics and Traumatology, Freiburg University Hospital, Freiburg, Germany

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T Nymark Department of Orthopedic Surgery, University Hospital Odense, Odense C, Denmark

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H Schmal Department of Orthopedics and Traumatology, Freiburg University Hospital, Freiburg, Germany
Department of Orthopedic Surgery, University Hospital Odense, Odense C, Denmark

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combination of impaired blood supply and hyperglycemic states further increases the risk of surgical-site infections ( 3 , 4 ). In such cases, as reported by Willy et al. , closed-incisional negative pressure wound therapy (iNPWT) has shown clinical

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İlker Eren Koç University, School of Medicine, Department of Orthopaedics and Traumatology, Istanbul, Turkey

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Cemil Cihad Gedik Koç University, School of Medicine, Department of Orthopaedics and Traumatology, Istanbul, Turkey

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Uğur Kılıç Koç University, School of Medicine, Istanbul, Turkey

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Berk Abay Koç University, School of Medicine, Istanbul, Turkey

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Olgar Birsel Koç University, School of Medicine, Department of Orthopaedics and Traumatology, Istanbul, Turkey

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Mehmet Demirhan Koç University, School of Medicine, Department of Orthopaedics and Traumatology, Istanbul, Turkey

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is variable depending on the region; however, more recent reports suggest a prevalence range of 1/8000 to 1/20 000 ( 7 , 8 , 9 ). This relatively wide range can be explained by an important number of undiagnosed cases due to the paucity of apparent

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Claus Varnum The Danish Hip Arthroplasty Register
Department of Orthopaedic Surgery, Vejle Hospital, Vejle, Denmark

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Alma Bečić Pedersen Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark

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Ola Rolfson The Swedish Hip Arthroplasty Register
Department of Orthopaedics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Cecilia Rogmark The Swedish Hip Arthroplasty Register
Lund University, Skåne University Hospital, Department of Orthopedics, Malmö, Sweden

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Ove Furnes The Norwegian Arthroplasty Register, Department of Orthopedic Surgery, Haukeland University Hospital, Bergen, Norway
Department of Clinical Medicine, University of Bergen, Bergen, Norway

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Geir Hallan The Norwegian Arthroplasty Register, Department of Orthopedic Surgery, Haukeland University Hospital, Bergen, Norway
Department of Clinical Medicine, University of Bergen, Bergen, Norway

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Keijo Mäkelä The Finnish Arthroplasty Register
Department of Orthopaedics and Traumatology, Turku University Hospital, Turku, Finland

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Richard de Steiger Australian Orthopaedic Association National Joint Replacement Registry (AOANJRR), Adelaide, Australia
Department of Surgery, Epworth HealthCare, University of Melbourne, Melbourne, Australia

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Martyn Porter The National Joint Registry of England, Wales, Northern Ireland and Isle of Man
Centre for Hip Surgery, Wrightington Hospital, Wrightington, Wigan and Leigh NHS Trust, Lancashire, United Kingdom

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Søren Overgaard The Danish Hip Arthroplasty Register
Orthopaedic Research Unit, Department of Clinical Research, University of Southern Denmark, Odense, Denmark
Department of Orthopaedic Surgery and Traumatology, Odense University Hospital, Odense, Denmark

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registers on orthopaedic practice can be obtained by open access transparent publication of results in scientific journals and annual reports, discussion of results and the role of registers at meeting in the orthopaedic community, feedback mechanisms to the

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Guillermo Droppelmann Research Center on Medicine, Exercise, Sport and Health, MEDS Clinic, Santiago, RM, Chile
Health Sciences PhD Program, Universidad Católica de Murcia UCAM, Murcia, Spain
Harvard T.H. Chan School of Public Health, Boston, USA

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Constanza Rodríguez Facultad de Medicina, Universidad Finis Terrae, Santiago, RM, Chile

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Dali Smague Facultad de Medicina, Universidad Finis Terrae, Santiago, RM, Chile

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Carlos Jorquera Facultad de Ciencias, Escuela de Nutrición y Dietética, Universidad Mayor, Santiago, RM, Chile

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Felipe Feijoo School of Industrial Engineering, Pontificia Universidad Católica de Valparaíso, Valparaíso, Chile

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. In other words, the algorithms can correctly identify negative cases in 95% of instances or have an estimation error of only 5%. However, specificity exhibits very high and significant heterogeneity in this instance. The reported values are τ ²= 1

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Juan Carlos Monllau Department of Orthopaedic Surgery, Hospital del Mar, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain
ICATKnee, Institut Catalá de Traumatologia i Medicina de l’Esport (ICATME), Hospital Universitari Dexeus, UAB, Barcelona, Spain

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Simone Perelli Department of Orthopaedic Surgery, Hospital del Mar, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain
ICATKnee, Institut Catalá de Traumatologia i Medicina de l’Esport (ICATME), Hospital Universitari Dexeus, UAB, Barcelona, Spain

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Giuseppe Gianluca Costa Orthopaedic Surgery Department, Ospedale Umberto I, Enna, Italy

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9.3% of cases, respectively. However, abnormal objective outcomes have been reported in one-third of all cases ( 5 ). Beyond that instability, Johnson and Fu proposed a more inclusive definition of failure considering also pain and stiffness ( 8

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Dieter Wirtz Department of Orthopaedic Surgery and Traumatology, University Hospital of Bonn, Germany

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Hendrik Kohlhof Department of Orthopaedic Surgery and Traumatology, University Hospital of Bonn, Germany

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% probability of a drug–drug interaction. In cases of frail elderly patients research has reported the prevalence of drug–disease interactions to be 15–40%. In a case-control study carried out among old-aged people, polypharmacy was found to be an independent

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