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Markus S. Hanke Department of Orthopaedic and Trauma Surgery, Inselspital, University of Bern, Bern, Switzerland

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Florian Schmaranzer Department of Diagnostic, Interventional and Pediatric Radiology, University Hospital of Bern, Inselspital, University of Bern, Bern, Switzerland

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Simon D. Steppacher Department of Orthopaedic and Trauma Surgery, Inselspital, University of Bern, Bern, Switzerland

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Till D. Lerch Department of Orthopaedic and Trauma Surgery, Inselspital, University of Bern, Bern, Switzerland

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Klaus A. Siebenrock Department of Orthopaedic and Trauma Surgery, Inselspital, University of Bern, Bern, Switzerland

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the localization, extension and stage of the osteonecrosis, multiple therapeutic options are available such as rotational osteotomies, bone grafting, core decompression and varus/flexion femoral osteotomy aiming to preserve the joint in these mostly

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Ignacio Sanpera Hospital Universitary Son Espases, Palma de Mallorca, Illes BalearsSpain

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Sandra Villafranca-Solano Hospital Universitary Son Espases, Palma de Mallorca, Illes BalearsSpain

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Carmen Muñoz-Lopez Hospital Universitary Son Espases, Palma de Mallorca, Illes BalearsSpain

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Julia Sanpera-Iglesias Evelina Children’s Hospital, London, UK

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with pes cavovarus, as is commonly done, because the diagnostic and therapeutic implications are completely different. Pes cavovarus denotes the presence of a three-dimensional deformity of the foot, but it is a descriptive feature not a diagnosis

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Sebastian Siebenlist Department of Orthopaedic Sports Medicine, Klinikum rechts der Isar, Technical University of Munich, Germany

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Arne Buchholz Department of Trauma Surgery, Klinikum rechts der Isar, Technical University of Munich, Germany

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Karl F. Braun Department of Trauma Surgery, Klinikum rechts der Isar, Technical University of Munich, Germany

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. 64. Pipicelli JG Chinchalkar SJ Grewal R King GJ . Therapeutic implications of the radiographic ‘drop sign’ following elbow dislocation . J Hand Ther 2012 ; 25 : 346 – 353 . 65. Hume MC

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François Lintz Centre de Chirurgie de la Cheville et du Pied, Clinique de l’Union, France

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Cesar de Cesar Netto Foot and Ankle Surgery Department, Hospital for Special Surgery, New York City, USA

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Alexeij Barg Foot and Ankle Surgery Department, University of Utah, USA

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Arne Burssens Foot and Ankle Surgery Department, University of Ghent, Belgium

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Martinus Richter Foot and Ankle Surgery Department, Rummelsberg, Germany

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Weight Bearing CT International Study Group WBCT ISG, Seattle, Washington, USA

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D XR as a 5° varus in one case and a 15° valgus in the other, a situation in which the therapeutic decisions in two patients with the same neutral alignment may be completely opposed. This is not something that can be assessed using numerical

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Xinhui Wu Department of Orthopedics, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China

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Xiaoxin Fang Department of Endocrinology and Metabolism, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China

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Feng Lu Nanjing Medical University, Jiangning, Nanjing, China

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Qiong Chen Jinhua TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China

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Junjian Liu Department of Orthopedics, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China

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Longpo Zheng Department of Orthopedics, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China
Orthopedic Intelligent Minimally Invasive Diagnosis and Treatment Center, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China

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). Over the past decade, ferroptosis has been shown to have great therapeutic potential for many diseases, including drug-resistant cancers, ischemic organ injuries, and other degenerative diseases like osteoporosis (OP). The results of existing literature

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Mara Meyer Günderoth Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany

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Alexandra Bannach-Brown Berlin Institute of Health at Charité – Universitätsmedizin Berlin, QUEST Center for Responsible Research, Berlin, Germany

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Tobias Winkler Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin Institute of Health Center for Regenerative Therapies, Berlin, Germany

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Johannes Keller Department of Trauma and Orthopedic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

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Robert Karl Zahn Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany

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Tazio Maleitzke Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Trauma Orthopaedic Research Copenhagen Hvidovre (TORCH), Department of Orthopaedic Surgery, Copenhagen University Hospital – Amager and Hvidovre, Hvidovre, Denmark
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark

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factor levels in patients with RA ( 28 ), its bone preserving effect on the skeleton was inferior to that of alendronate ( 29 ). For OA, two large randomized-controlled trials failed to show a statistically significant therapeutic effect of sCT regarding

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Jie Xiang Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Weibo Zhao Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Xiao Luo Department of Radiology, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Zhenghua Hong Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Hua Luo Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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was diagnosed with acute spontaneous spinal subdural hematoma presenting with TTC. Therapeutic intervention Because of the extensive craniocaudal extension of SSDH, conservative treatment was chosen, with readiness for surgery in case of

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Thomas Collins Trauma & Orthopaedics, Wythenshawe Hospital, Wythenshawe, UK

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Dinesh Alexander Trauma & Orthopaedics, Salford Royal Hospital, Salford, UK

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Bilal Barkatali Trauma & Orthopaedics, Salford Royal Hospital, Salford, UK

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concentration was significantly elevated in all systems compared to whole blood, and variation was seen with pH, RBC and neutrophil levels. The exact implications of differing compositional elements are still unknown and will be considered later in the article

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Irina-Anca Eremia Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Department of Emergency Medicine, Emergency University Hospital, Bucharest, Romania

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Bogdan Serban Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Department of Orthopaedics and Traumatology, Emergency University Hospital Bucharest, Romania

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Mihnea Popa Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Department of Orthopaedics and Traumatology, Emergency University Hospital Bucharest, Romania

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Adela Iancu Carol Davila University of Medicine and Pharmacy, Bucharest, Romania

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Silvia Nica Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Department of Emergency Medicine, Emergency University Hospital, Bucharest, Romania

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Catalin Cirstoiu Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Department of Orthopaedics and Traumatology, Emergency University Hospital Bucharest, Romania

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the therapeutic possibilities of modulating this pathway ( 32 ). Additionally, the involvement of the calcium-sensing receptor (CaSR) in the spread of cancer to the bones in RCC is a topic that is gaining attention ( 33 ). The participation of CaSR in

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Bogdan Serban Department of Orthopedics and Traumatology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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Bogdan Cretu Department of Orthopedics and Traumatology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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Adrian Cursaru Department of Orthopedics and Traumatology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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Cornelia Nitipir Department of Oncology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Elias University Emergency Hospital, Bucharest, Romania

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Cristina Orlov-Slavu Department of Oncology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Elias University Emergency Hospital, Bucharest, Romania

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Catalin Cirstoiu Department of Orthopedics and Traumatology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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cannot be made with complete certainty following only imaging investigations or clinical examination; the locoregional changes after primary resection are significant, which creates a risk of false positive suspicion. The implications of a possible

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