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the localization, extension and stage of the osteonecrosis, multiple therapeutic options are available such as rotational osteotomies, bone grafting, core decompression and varus/flexion femoral osteotomy aiming to preserve the joint in these mostly
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with pes cavovarus, as is commonly done, because the diagnostic and therapeutic implications are completely different. Pes cavovarus denotes the presence of a three-dimensional deformity of the foot, but it is a descriptive feature not a diagnosis
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. 64. Pipicelli JG Chinchalkar SJ Grewal R King GJ . Therapeutic implications of the radiographic ‘drop sign’ following elbow dislocation . J Hand Ther 2012 ; 25 : 346 – 353 . 65. Hume MC
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D XR as a 5° varus in one case and a 15° valgus in the other, a situation in which the therapeutic decisions in two patients with the same neutral alignment may be completely opposed. This is not something that can be assessed using numerical
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Orthopedic Intelligent Minimally Invasive Diagnosis and Treatment Center, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China
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). Over the past decade, ferroptosis has been shown to have great therapeutic potential for many diseases, including drug-resistant cancers, ischemic organ injuries, and other degenerative diseases like osteoporosis (OP). The results of existing literature
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Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin Institute of Health Center for Regenerative Therapies, Berlin, Germany
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Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Trauma Orthopaedic Research Copenhagen Hvidovre (TORCH), Department of Orthopaedic Surgery, Copenhagen University Hospital – Amager and Hvidovre, Hvidovre, Denmark
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factor levels in patients with RA ( 28 ), its bone preserving effect on the skeleton was inferior to that of alendronate ( 29 ). For OA, two large randomized-controlled trials failed to show a statistically significant therapeutic effect of sCT regarding
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was diagnosed with acute spontaneous spinal subdural hematoma presenting with TTC. Therapeutic intervention Because of the extensive craniocaudal extension of SSDH, conservative treatment was chosen, with readiness for surgery in case of
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concentration was significantly elevated in all systems compared to whole blood, and variation was seen with pH, RBC and neutrophil levels. The exact implications of differing compositional elements are still unknown and will be considered later in the article
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the therapeutic possibilities of modulating this pathway ( 32 ). Additionally, the involvement of the calcium-sensing receptor (CaSR) in the spread of cancer to the bones in RCC is a topic that is gaining attention ( 33 ). The participation of CaSR in
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cannot be made with complete certainty following only imaging investigations or clinical examination; the locoregional changes after primary resection are significant, which creates a risk of false positive suspicion. The implications of a possible