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Claudio Rosso ARTHRO Medics, Shoulder and Elbow Center, Basel, Switzerland
University of Basel, Basel, Switzerland
Swiss Orthopaedics, Grandvaux, Switzerland

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Mark E Morrey Swiss Orthopaedics, Grandvaux, Switzerland

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Michael O Schär Swiss Orthopaedics, Grandvaux, Switzerland

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Kushtrim Grezda ARTHRO Medics, Shoulder and Elbow Center, Basel, Switzerland
University of Basel, Basel, Switzerland
Department of Orthopedic Surgery, Division of Shoulder and Elbow, Mayo Clinic, Rochester, Minnesota

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the Swiss Orthopaedics Shoulder Elbow and Expert Group †
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the Swiss Orthopaedics Shoulder Elbow and Expert Group

, augmentation did not translate into improved clinical outcomes at 1 year ( 46 ). Another prospective randomized study published by D’Ambrosii et al. aimed to compare the efficacy of L-PRP augmentation to surgery alone on clinical outcomes of 40 patients

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Di Zhao The Second Clinical School of Guangzhou University of Chinese Medicine, Guangzhou, China
Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China

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Ling-feng Zeng The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China

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Gui-hong Liang The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China

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Jian-ke Pan The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China

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Ming-hui Luo The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China

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Yan-hong Han The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China

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Jun Liu Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China
Guangdong Second Traditional Chinese Medicine Hospital (Guangdong Province Engineering Technology Research Institute of Traditional Chinese Medicine), Guangzhou, China
The fifth Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, China

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Wei-yi Yang The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China

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-controlled, dose-ranging, dose-loading phase II study . Clinical Therapeutics 2016 38 1435 – 1450 . ( https://doi.org/10.1016/j.clinthera.2016.03.030 ) 32. Kivitz AJ Gimbel JS Bramson C Nemeth MA Keller DS Brown MT West CR Verburg KM . Efficacy

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Önder İ. Kılıçoğlu Department of Orthopaedics and Traumatology, İstanbul University, Istanbul Faculty of Medicine, Turkey

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Mehmet Demirel Department of Orthopaedics and Traumatology, İstanbul University, Istanbul Faculty of Medicine, Turkey

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Şamil Aktaş Department of Underwater and Hyperbaric Medicine, İstanbul University, Istanbul Faculty of Medicine, Turkey

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regions to prevent these regions from the onset and recurrence of DFU, which is done by encouraging effective pressure off-loading. 28 , 33 , 34 Nevertheless, the efficacy and feasibility of these techniques are rarely studied in clinical practice

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Xun Wang Department of Orthopedics, Center for Plastic & Reconstructive Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, Zhejiang, China
Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China

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Aiqi Zhang Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China

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Wenchao Yao Department of Orthopaedics, the First People's Hospital of Chun'an County, Hangzhou, Zhejiang, China

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Haiyan Qiu Department of Endocrinology, Afliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China

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Fabo Feng Department of Orthopedics, Center for Plastic & Reconstructive Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, Zhejiang, China

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categories – #1 and #4: Clinical Outcomes, #2 and #6: Surgical Technique, #3: Surgical Efficacy, and #5: Surgical Safety. It was evident from the figure that the TLIF technique itself and the efficacy of TLIF in treating lumbar disorders were hot research

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Valentina Viglione Clinica Ortopedica e Traumatologica 1 IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

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Angelo Boffa Applied and Translational Research (ATR) Center, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

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Davide Previtali Department of Surgery, EOC, Service of Orthopaedics and Traumatology, Lugano, Switzerland

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Francesca Vannini Clinica Ortopedica e Traumatologica 1 IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

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Cesare Faldini Clinica Ortopedica e Traumatologica 1 IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

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Giuseppe Filardo Applied and Translational Research (ATR) Center, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
Department of Surgery, EOC, Service of Orthopaedics and Traumatology, Lugano, Switzerland
Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland

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for foot problems ( 60 , 61 ). This finding is of high clinical relevance and questions the real efficacy of the conservative treatments used for the management of plantar fasciitis. In fact, an improvement reported after a hypothetically effective

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Maria Anna Smolle Department of Orthopaedics and Trauma, Medical University of Graz, Graz, Austria

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Joanna Szkandera Division of Clinical Oncology, Internal Medicine, Medical University of Graz, Graz, Austria

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Dimosthenis Andreou Division of Orthopaedic Oncology and Sarcoma Surgery, Helios Klinikum Bad Saarow, Sarcoma Center Berlin-Brandenburg, Berlin, Germany

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Emanuela Palmerini Chemotherapy Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna University, Bologna, Italy

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Marko Bergovec Department of Orthopaedics and Trauma, Medical University of Graz, Graz, Austria

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Andreas Leithner Department of Orthopaedics and Trauma, Medical University of Graz, Graz, Austria

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respective studies. Furthermore, study limitations, levels of evidence according to the Oxford Centre for Evidence Based Medicine Levels of Evidence Scale, 10 and clinical efficacy in distinct histological subtypes were documented. Fig. 1 PRISMA

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Søren Overgaard Department of Orthopaedic Surgery and Traumatology, Copenhagen University Hospital, Copenhagen, Denmark
Department of Clinical Medicine, Faculty of Health & Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Thomas M Grupp Aesculap AG Research & Development & Medical Scientific Affairs, Tuttlingen, Germany
Department of Orthopaedic and Trauma Surgery, Ludwig Maximilians University Munich, Musculoskeletal University Center Munich (MUM), Campus Grosshadern, Munich, Germany

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Rob GHH Nelissen Department of Orthopaedics, Leiden University Medical Center, Leiden, the Netherlands
Technical University Delft, Delft, the Netherlands

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Luca Cristofolini Department of Industrial Engineering, School of Engineering and Architecture, Alma Mater Studiorum - Università di Bologna, Bologna, Italy

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Anne Lübbeke Division of Surgery and Traumatology, Geneva University Hospitals and University of Geneva, Switzerland
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, UK

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Marcus Jäger Department of Orthopaedics, Trauma & Reconstructive Surgery St. Marien Hospital Mülheim an der Ruhr & Chair of Orthopaedics and Trauma Surgery University of Duisburg–Essen, Essen, Germany

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Matthias Fink TÜV Süd Product Service GmbH, Clinical Centre of Excellence, Munich Germany

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Sabine Rusch Aesculap AG Research & Development & Medical Scientific Affairs, Tuttlingen, Germany

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Hassan Achakri Zimmer Biomet, Clinical, Regulatory & Quality Affairs, Winterthur, Switzerland

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Francesco Benazzo IUSS Pavia, Fondazione Poliambulanza Istituto Ospedaliero, Brescia, Italy

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Dario Bergadano Medacta International SA, Medical Affairs, Castel San Pietro, Switzerland

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Georg N Duda Julius Wolff Institute and Center for Muskuloskeletal Surgery, Berlin Institute of Health at Charité Universitätsmedizin Berlin, Germany

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Christian Kaddick EndoLab Mechanical Engineering GmbH, Riedering, Germany

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Volkmar Jansson Department of Orthopaedic and Trauma Surgery, Ludwig Maximilians University Munich, Musculoskeletal University Center Munich (MUM), Campus Grosshadern, Munich, Germany

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Klaus-Peter Günther University Clinic Carl Gustav Carus, Center for Orthopaedic & Trauma Surgery, Technical University Dresden, Dresden, Germany

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specific amount of clinical documentation is required to receive the CE mark and to regularly provide proof of clinical safety and efficacy. The documentation must contain sufficient information for the assessment of safety and performance when used as

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Alessandro Bensa Service of Orthopaedics and Traumatology, Department of Surgery, EOC, Lugano, Switzerland

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Alessandro Sangiorgio Service of Orthopaedics and Traumatology, Department of Surgery, EOC, Lugano, Switzerland

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Angelo Boffa Applied and Translational Research (ATR) Center, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

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Manuela Salerno Applied and Translational Research (ATR) Center, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

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Giacomo Moraca Service of Orthopaedics and Traumatology, Department of Surgery, EOC, Lugano, Switzerland

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Giuseppe Filardo Service of Orthopaedics and Traumatology, Department of Surgery, EOC, Lugano, Switzerland
Applied and Translational Research (ATR) Center, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
Università della Svizzera Italiana, Faculty of Biomedical Sciences, Lugano, Switzerland

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investigate which patient categories could benefit the most from each individual product in order to maximize treatment efficacy and tailor the therapy to the specific patient characteristics, optimizing the management of knee OA in the clinical practice

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Jean-Charles Le Huec Polyclinique Bordeaux Nord Aquitaine, Bordeaux Univ, 33 300 Bordeaux, France

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Stephane Bourret Polyclinique Bordeaux Nord Aquitaine, Bordeaux Univ, 33 300 Bordeaux, France

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Wendy Thompson Polyclinique Bordeaux Nord Aquitaine, Bordeaux Univ, 33 300 Bordeaux, France

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Christian Daulouede Polyclinique Bordeaux Nord Aquitaine, Bordeaux Univ, 33 300 Bordeaux, France

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Thibault Cloché Polyclinique Bordeaux Nord Aquitaine, Bordeaux Univ, 33 300 Bordeaux, France

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pain: a randomized clinical trial with 3, 6, and 12 months follow-up postpartum . Spine (Phila Pa 1976) 2005 ; 30 : 850 – 856 . 15. Stuge B Veierød MB Laerum E Vøllestad N . The efficacy of a treatment

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Mukai Chimutengwende-Gordon Joint Reconstruction Unit, Royal National Orthopaedic Hospital Trust, Stanmore, UK

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James Donaldson Joint Reconstruction Unit, Royal National Orthopaedic Hospital Trust, Stanmore, UK

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George Bentley Joint Reconstruction Unit, Royal National Orthopaedic Hospital Trust, Stanmore, UK

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regarding the clinical efficacy of gene therapy. Conclusions The current methods commonly used clinically to treat osteochondral lesions mainly result in fibrocartilage formation and are only suitable for the treatment of small defects less than 2

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