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E Carlos Rodríguez-Merchán
E Carlos Rodríguez-Merchán
Department of Orthopaedic Surgery, La Paz University Hospital, Madrid, Spain
Osteoarticular Surgery Research, Hospital La Paz Institute for Health Research – IdiPAZ (La Paz University Hospital – Autonomous University of Madrid), Madrid, Spain
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Osteoarticular Surgery Research, Hospital La Paz Institute for Health Research – IdiPAZ (La Paz University Hospital – Autonomous University of Madrid), Madrid, Spain
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Alberto D Delgado-Martínez
Alberto D Delgado-Martínez
Department of Orthopaedic Surgery, Hospital Universitario de Jaén, Jaén, Spain
Department of Surgery, University of Jaén, Jaén, Spain
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Department of Surgery, University of Jaén, Jaén, Spain
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Javier De Andrés-Ares
Javier De Andrés-Ares
Department of Anesthetics, Pain Unit, La Paz University Hospital, Madrid, Spain
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(NSAIDs), weight loss, and physical and rehabilitation medicine) has failed to provide alleviation and the patient is not a candidate for surgery. RF is contraindicated for pregnant women, patients with unstable joints (hip, knee, and shoulder), those with
Shaho Hasan
Shaho Hasan
Department of Orthopaedics, Leiden University Medical Centre, Leiden, The Netherlands
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Peter van Schie
Peter van Schie
Department of Orthopaedics, Leiden University Medical Centre, Leiden, The Netherlands
Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands
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Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands
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Bart L Kaptein
Bart L Kaptein
Department of Orthopaedics, Leiden University Medical Centre, Leiden, The Netherlands
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Jan W Schoones
Jan W Schoones
Walaeus Library, Leiden University Medical Centre, Leiden, The Netherlands
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Perla J Marang-van de Mheen
Perla J Marang-van de Mheen
Department of Orthopaedics, Leiden University Medical Centre, Leiden, The Netherlands
Department of Safety & Security Science, Delft University of Technology, Delft, The Netherlands
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Department of Safety & Security Science, Delft University of Technology, Delft, The Netherlands
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Rob G H H Nelissen
Rob G H H Nelissen
Department of Orthopaedics, Leiden University Medical Centre, Leiden, The Netherlands
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failing to fulfill the mandatory criteria were classified as moderate-quality (MQ) studies. Studies scoring less than 18 points were classified as low-quality (LQ) studies. There were no studies that fulfilled all the mandatory criteria but failed to score
Anna Bogdanova-Bennett
Anna Bogdanova-Bennett
Academic Surgical Unit, South West London Elective Orthopaedic Centre, Epsom, UK
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Amit Sagi
Amit Sagi
Academic Surgical Unit, South West London Elective Orthopaedic Centre, Epsom, UK
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Vipin Asopa
Vipin Asopa
Academic Surgical Unit, South West London Elective Orthopaedic Centre, Epsom, UK
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Richard E. Field
Richard E. Field
Academic Surgical Unit, South West London Elective Orthopaedic Centre, Epsom, UK
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David H. Sochart
David H. Sochart
Academic Surgical Unit, South West London Elective Orthopaedic Centre, Epsom, UK
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(patch substances used; time point at which patch test was performed) Prevalence of nickel hypersensitivity (before and/or after surgery) Clinical results (e.g. complications, stable or failed implant, adverse reaction to metal debris, systemic
T. Fintan Moriarty
T. Fintan Moriarty
AO Research Institute Davos, Switzerland
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Richard Kuehl
Richard Kuehl
University Hospital of Basel, Switzerland
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Tom Coenye
Tom Coenye
Ghent University, Belgium
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Willem-Jan Metsemakers
Willem-Jan Metsemakers
University Hospitals Leuven, Belgium
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Mario Morgenstern
Mario Morgenstern
Trauma Centre, Murnau, Germany
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Edward M. Schwarz
Edward M. Schwarz
University of Rochester Medical Center, New York, USA
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Martijn Riool
Martijn Riool
AMC, University of Amsterdam, The Netherlands
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Sebastian A.J. Zaat
Sebastian A.J. Zaat
AMC, University of Amsterdam, The Netherlands
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Nina Khana
Nina Khana
University Hospital of Basel, Switzerland
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Stephen L. Kates
Stephen L. Kates
Virginia Commonwealth University, Virginia, USA
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R. Geoff Richards
R. Geoff Richards
AO Research Institute Davos, Switzerland
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, treat and potentially eradicate ODRIs. Unfortunately, all efforts to develop an effective vaccine against S. aureus , the primary pathogen involved in ODRI, have failed for a number of reasons ( Table 3 ). 66 - 68 The most prominent reason is
Hua Luo
Hua Luo
Department of Orthopedics, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China
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Congcong He
Congcong He
Department of Psychology, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China
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Yong Zhao
Yong Zhao
Department of Orthopedics, Shanghai Fengxian District Central Hospital, Shanghai, China
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Guangyong Yang
Guangyong Yang
Department of Orthopedics, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China
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Hainan Hong
Hainan Hong
Department of Orthopedics, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China
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aspiration, initiating appropriate antibiotic therapy, and considering surgical interventions such as joint drainage or arthroplasty when conservative measures fail or joint destruction is severe ( 12 ). The treatment approach should be individualized based
Ahmed Halloum
Ahmed Halloum
Interdisciplinary Orthopaedics, Aalborg University Hospital, Hobrovej, Aalborg, Denmark
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Søren Kold
Søren Kold
Interdisciplinary Orthopaedics, Aalborg University Hospital, Hobrovej, Aalborg, Denmark
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Jan Duedal Rölfing
Jan Duedal Rölfing
Department of Orthopaedics, Aarhus University Hospital, Palle Juul-Jensens Boulevard, Aarhus, Denmark
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Ahmed A Abood
Ahmed A Abood
Interdisciplinary Orthopaedics, Aalborg University Hospital, Hobrovej, Aalborg, Denmark
Department of Orthopaedics, Aarhus University Hospital, Palle Juul-Jensens Boulevard, Aarhus, Denmark
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Department of Orthopaedics, Aarhus University Hospital, Palle Juul-Jensens Boulevard, Aarhus, Denmark
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Ole Rahbek
Ole Rahbek
Interdisciplinary Orthopaedics, Aalborg University Hospital, Hobrovej, Aalborg, Denmark
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failed to load. Furthermore, reference lists of all included studies were screened. Together this resulted in the inclusion of additional seven studies ( 12 , 13 , 14 , 17 , 18 , 19 , 20 ) ( Fig. 1 ). Figure 1 PRISMA flow diagram for the
Tobias Winkler
Tobias Winkler
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
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Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
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Sven Geissler
Sven Geissler
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
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Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
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Tazio Maleitzke
Tazio Maleitzke
Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
Trauma Orthopaedic Research Copenhagen Hvidovre (TORCH), Department of Orthopaedic Surgery, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
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Trauma Orthopaedic Research Copenhagen Hvidovre (TORCH), Department of Orthopaedic Surgery, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
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Carsten Perka
Carsten Perka
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
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Georg N Duda
Georg N Duda
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
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Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
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Alexander Hildebrandt
Alexander Hildebrandt
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
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Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
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)-approved drugs were listed for cancer therapy. Many of them are classified as biologics ( 7 ). In contrast, advanced biologic therapeutics in orthopaedics, such as cell therapies, have so far mostly failed to reach primary endpoints and get regulatory approval
Tommaso Bonanzinga
Tommaso Bonanzinga
Humanitas University, Department of Biomedical Sciences, Milan, Italy
Humanitas Clinical and Research Center, Milan, Italy
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Humanitas Clinical and Research Center, Milan, Italy
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Matteo Carlo Ferrari
Matteo Carlo Ferrari
Humanitas Clinical and Research Center, Milan, Italy
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Piergiuseppe Tanzi
Piergiuseppe Tanzi
IRCCS Istituto Ortopedico Rizzoli; Università di Bologna, Dipartimento Scienze Biomediche e Neuromotorie, Bologna, Italy
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Filippo Vandenbulcke
Filippo Vandenbulcke
Humanitas University, Department of Biomedical Sciences, Milan, Italy
Humanitas Clinical and Research Center, Milan, Italy
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Humanitas Clinical and Research Center, Milan, Italy
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Akos Zahar
Akos Zahar
Helios ENDO-Klinik, Hamburg, Germany
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Maurilio Marcacci
Maurilio Marcacci
Humanitas University, Department of Biomedical Sciences, Milan, Italy
Humanitas Clinical and Research Center, Milan, Italy
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Humanitas Clinical and Research Center, Milan, Italy
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Introduction Prosthetic joint infections (PJI) occur in 0.7% to 2.4% of patients and are responsible for 15% of failed total hip arthroplasties and 25% of revision total knee arthroplasties. 1 , 2 Almost any microorganism can cause PJI
AliSina Shahi
AliSina Shahi
The Rothman Institute at Thomas Jefferson University, Philadelphia, USA
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Javad Parvizi
Javad Parvizi
The Rothman Institute at Thomas Jefferson University, Philadelphia, USA
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Introduction Periprosthetic joint infection (PJI) is responsible for 25% of failed total knee arthroplasties 1 and 15% of revision total hip arthroplasties. 2 PJI has a huge economic burden on the health care system, and there will
Michael de Buys
Michael de Buys
Orthopaedic Surgery, University of Witswatersrand, Johannesburg, South Africa
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Krisantha Moodley
Krisantha Moodley
Emergency Department, ER Consulting, Johannesburg, South Africa
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Josip Nenad Cakic
Josip Nenad Cakic
Department Orthopaedic Surgery, Life Fourways Hospital, Johannesburg, South Africa
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Jurek R T Pietrzak
Jurek R T Pietrzak
Orthopaedic Surgery, University of Witswatersrand, Johannesburg, South Africa
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, treatment of S. aureus colonization is more likely to fail when there is involvement of multiple anatomical sites, longer hospital admissions and bacterial resistance to mupirocin ( 75 ). Ammerlaan et al. reported that resistance to mupirocin developed
