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Donald J. Davidson Research Department of Orthopaedics and Musculoskeletal Sciences, University College London, London, UK
Department of Microbial Diseases, UCL Eastman Dental Institute, University College London, London, UK

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David Spratt Department of Microbial Diseases, UCL Eastman Dental Institute, University College London, London, UK

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Alexander D. Liddle Department of Microbial Diseases, UCL Eastman Dental Institute, University College London, London, UK
MSK Lab, Imperial College London, London, UK

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attachment and maturation, and as such play a crucial role in PJI. 22 Biofilms are not only formed on the prosthesis but, in the context of PJI, can be found on bone cement, the bone itself, and fibrous tissue; detached clumps can be found in the

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Ippokratis Pountos Academic Department of Trauma & Orthopaedics, School of Medicine, University of Leeds, UK

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Peter V. Giannoudis Academic Department of Trauma & Orthopaedics, School of Medicine, University of Leeds, and NIHR Leeds Biomedical Research Unit, Chapel Allerton Hospital, LS7 4SA Leeds, West Yorkshire, Leeds, UK

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substitutes has been popularised. Synthetic materials commonly used to fill bone voids include ceramics, PMMA (polymethylmethacrylate bone cement), bio-active glasses, porous metals, corals and synthetic polymers. 15 They can be absorbable or permanent

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Christoph H. Lohmann Department of Orthopeadic Surgery, Otto-von-Guericke University, Leipziger Str. 44,39120 Magdeburg, Germany

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Sanjiv Rampal Department of Orthopeadic Surgery, Otto-von-Guericke University, Leipziger Str. 44,39120 Magdeburg, Germany

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Martin Lohrengel Department of Orthopeadic Surgery, Otto-von-Guericke University, Leipziger Str. 44,39120 Magdeburg, Germany

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Gurpal Singh Division of Musculoskeletal Oncology, University Orthopaedics Hand and Reconstructive Microsurgery Cluster, National University Health System, 1E Kent Ridge Road, 119228 Singapore

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functionally equivalent to glenoid retroversion. Clinically, this is of relevance as significantly increased stress within the cement mantle and the glenoid bone as well as increased micromotion at the bone-cement interface has been associated with glenoid

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Sylvain Steinmetz Service of Orthopaedics and Traumatology, Lausanne University Hospital, Lausanne, Switzerland

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Diane Wernly Service of Orthopaedics and Traumatology, Lausanne University Hospital, Lausanne, Switzerland

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Kevin Moerenhout Service of Orthopaedics and Traumatology, Lausanne University Hospital, Lausanne, Switzerland

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Andrej Trampuz Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery (CMSC), Berlin, Germany

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Olivier Borens Service of Orthopaedics and Traumatology, Lausanne University Hospital, Lausanne, Switzerland

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polymethylmethacrylate bone cements and Staphylococcus aureus biofilm formation . Acta Orthop Scand 2000 ; 71 : 625 – 629 . 23. Zimmerli W Widmer AF Blatter M Frei R Ochsner PE ; Foreign-Body Infection (FBI) Study

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Salvi Prat-Fabregat Hospital Clinic of Barcelona, Spain

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Pilar Camacho-Carrasco Hospital Clinic of Barcelona, Spain

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filled up with autologous or heterologous bone graft or with bone cement. To date there is insufficient evidence about the best method, but autologous bone graft use, probably the gold standard in young patients, is related to troublesome donor site pain

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Stefan Rammelt University Center of Orthopaedics & Traumatology, University Hospital Carl Gustav Carus, Dresden, Germany

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Bone cements may be used to augment fixation in severely osteoporotic bone. Polymethylmethacrylate (PMMA) cement is biomechanically stable and has been widely used to enhance pull-out strength with screw fixation. Screws are inserted into the cement

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Xinhuan Lei Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Jie Xiang Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Hailan Yang Department of Ultrasound, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Hongya Bao Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Zhong Zhu Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Hua Luo Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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retrospective studies. We expect that additional large studies (including RCTs) will further certify our conclusions in the future. Seventh, Klasan et al. and Park et al. used antibiotic-containing bone cement during the TKA, which is a possible confounding

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E. Carlos Rodríguez-Merchán Department of Orthopaedic Surgery, La Paz University Hospital, Madrid, Spain
Osteoarticular Surgery Research, La Paz Hospital Health Research Institute – IdiPAZ (La Paz University Hospital – Autonomous University of Madrid), Madrid, Spain

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Primitivo Gómez-Cardero Department of Orthopaedic Surgery, La Paz University Hospital, Madrid, Spain

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Carlos A. Encinas-Ullán Department of Orthopaedic Surgery, La Paz University Hospital, Madrid, Spain

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techniques correlated. Therefore, before rTKA, the sole utilization of the X-ray is possible. 17 Treatment options for managing bone loss in revision total knee arthroplasty The treatment options for managing bone loss in rTKA include bone cement

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Andy Craig Department of Trauma & Orthopaedics, Leeds Teaching Hospitals, Leeds, UK

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S W King Department of Trauma & Orthopaedics, Leeds Teaching Hospitals, Leeds, UK

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B H van Duren Leeds Institute of Rheumatic Musculoskeletal Medicine (LIRMM), Chapel Allerton Hospital, Leeds, UK

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V T Veysi Department of Trauma & Orthopaedics, Leeds Teaching Hospitals, Leeds, UK
Leeds Institute of Rheumatic Musculoskeletal Medicine (LIRMM), Chapel Allerton Hospital, Leeds, UK

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S Jain Department of Trauma & Orthopaedics, Leeds Teaching Hospitals, Leeds, UK
Leeds Institute of Rheumatic Musculoskeletal Medicine (LIRMM), Chapel Allerton Hospital, Leeds, UK

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J Palan Department of Trauma & Orthopaedics, Leeds Teaching Hospitals, Leeds, UK
Leeds Institute of Rheumatic Musculoskeletal Medicine (LIRMM), Chapel Allerton Hospital, Leeds, UK

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adverse consequences include burden of systemic antibiotic therapy, change in inter-family dynamics and profound psychological impacts ( 15 ). The use of antibiotic-impregnated/antibiotic-eluting bone cement The use of antimicrobials in

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Zaki Arshad University of Cambridge School of Clinical Medicine, Cambridge, UK

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Edward Jun-Shing Lau University of Cambridge School of Clinical Medicine, Cambridge, UK

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Aiman Aslam University of Cambridge School of Clinical Medicine, Cambridge, UK

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Azeem Thahir Department of Trauma and Orthopaedic Surgery, Addenbrooke’s Hospital, Cambridge, UK

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Matija Krkovic Department of Trauma and Orthopaedic Surgery, Addenbrooke’s Hospital, Cambridge, UK

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reamer-irrigator-aspirator system and antibiotic cement rods, finding no recurrence in 96% of patients. 7 Meanwhile, Huang et al utilized debridement and sequestrectomy with placement of an antibiotic-impregnated bone cement, reporting recurrence of

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