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E. Carlos Rodríguez-Merchán Department of Orthopaedic Surgery, “La Paz” University Hospital-IdiPaz, Madrid, Spain

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review the various prosthetic knee hinge models that have been used since 1975, with the purpose of analysing their indications and results. Table 1. Summary of hinge knee prosthesis designs published in the literature since 1975 Design

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Ismail Remzi Tözün Department of Orthopaedic Surgery and Traumatology, Acibadem Mehmet Ali Aydınlar University, School of Medicine, Acibadem Maslak Hospital, Sarıyer/Istanbul, Turkey

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Vahit Emre Ozden Department of Orthopaedic Surgery and Traumatology, Acibadem Mehmet Ali Aydınlar University, School of Medicine, Acibadem Maslak Hospital, Sarıyer/Istanbul, Turkey

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Goksel Dikmen Department of Orthopaedic Surgery and Traumatology, Acibadem Mehmet Ali Aydınlar University, School of Medicine, Acibadem Maslak Hospital, Sarıyer/Istanbul, Turkey

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Kayahan Karaytuğ Department of Orthopaedic Surgery and Traumatology, Acibadem Mehmet Ali Aydınlar University, School of Medicine, Acibadem Maslak Hospital, Sarıyer/Istanbul, Turkey

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Parvizi J . Infection burden for hip and knee arthroplasty in the United States . J Arthroplasty 2008 ; 23 : 984 – 991 . 4. Kurtz SM Ong KL Lau E Bozic KJ Berry D Parvizi J . Prosthetic

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Colby Foster Department of Orthopaedic Surgery, Michigan Medicine, Ann Arbor, Michigan, USA

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Christopher Posada Department of Orthopaedic Surgery, Michigan Medicine, Ann Arbor, Michigan, USA
Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA

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Bryan Pack River Valley Orthopaedics/Orthopaedic Associates of Michigan, Grand Rapids, Michigan, USA

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Brian R. Hallstrom Department of Orthopaedic Surgery, Michigan Medicine, Ann Arbor, Michigan, USA

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Richard E. Hughes Department of Orthopaedic Surgery, Michigan Medicine, Ann Arbor, Michigan, USA
Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA
Department of Industrial & Operations Engineering, University of Michigan, Michigan, USA

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Introduction Evidence-based medicine is central to providing the highest quality care to total knee arthroplasty (TKA) patients. Patients have many types of outcomes, including infection, venous thromboembolism, death, readmission, peri-prosthetic

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Carlos A. Encinas-Ullán Department of Orthopaedic Surgery, La Paz University Hospital-IdiPaz, Madrid, Spain

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Primitivo Gómez-Cardero Department of Orthopaedic Surgery, La Paz University Hospital-IdiPaz, Madrid, Spain

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Juan S. Ruiz-Pérez Department of Orthopaedic Surgery, La Paz University Hospital-IdiPaz, Madrid, Spain

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E. Carlos Rodríguez-Merchán Osteoarticular Surgery Research Hospital, La Paz Institute for Health Research – IdiPAZ (La Paz University Hospital – Autonomous University of Madrid), Madrid, Spain

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% have been reported with RH-TKAs, with infections and aseptic loosening the most frequent complications. 1 Patellar instability and prosthetic dislocation can also occur. The dislocation of a RH-TKA is a complication described in the literature

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Chengxin Xie Department of Orthopedics, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Wenjun Pan Department of Orthopedics, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Shouli Wang Department of Orthopedics, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Xueli Yan Department of Orthopedics, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Hua Luo Department of Orthopedics, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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keywords ‘(periprosthetic joint infection or prosthetic joint infection) and (Two-stage or 2-stage or two stage or second-stage or double-stage) and (Single-stage or one-stage or 1-stage) and knee and (unhealed or infection or reoperate* or revise or

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Anoop K. Prasad Department of Trauma and Orthopaedic Surgery, Royal London Hospital, Barts Health NHS Trust, London, UK

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Jaimee H.S. Tan Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, UK

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Hany S. Bedair Department of Orthopaedics, Massachusetts General Hospital, Boston, Massachusetts, USA
Kaplan Joint Center, Department of Orthopaedics, Newton-Wellesley Hospital, Newton, Massachusetts, USA

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Sebastian Dawson-Bowling Department of Trauma and Orthopaedic Surgery, Royal London Hospital, Barts Health NHS Trust, London, UK

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Sammy A. Hanna Department of Trauma and Orthopaedic Surgery, Royal London Hospital, Barts Health NHS Trust, London, UK

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Press-Fit Condylar cruciate retaining (CR) TKAs (19.3%), 360 NextGen CR prosthetic TKAs (47.7%), 168 Low Contact Stress TKAs (22.3%), and 81 Scorpio CR TKAs (10.7%). The results of the six studies and cohort characteristics are summarized in Tables 1

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Piti Rattanaprichavej Department of Orthopaedics, Faculty of Medicine, Naresuan University, Phitsanulok, Thailand

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Patapong Towiwat Department of Internal Medicine, Faculty of Medicine, Naresuan University, Phitsanulok, Thailand

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Artit Laoruengthana Department of Orthopaedics, Faculty of Medicine, Naresuan University, Phitsanulok, Thailand

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Piyameth Dilokthornsakul Center of Pharmaceutical Outcomes Research, Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand
Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand

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Nathorn Chaiyakunapruk Department of Pharmacotherapy, College of Pharmacy, University of Utah, Salt Lake City, Utah, USA
School of Pharmacy, University of Wisconsin, Madison, Wisconsin, USA

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. Characteristics and outcomes of included studies Author (year) No. of knees Mean age (yr.) Average follow-up (yr.) Cause of CNA Staging Ataxia Prosthetic constraint (knees) Bone defect Rx Re-surgery (episodes) Total complication

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E. Carlos Rodríguez-Merchán Department of Orthopaedic Surgery, La Paz University Hospital, Madrid, Spain
Osteoarticular Surgery Research, La Paz Hospital Health Research Institute – IdiPAZ (La Paz University Hospital – Autonomous University of Madrid), Madrid, Spain

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Primitivo Gómez-Cardero Department of Orthopaedic Surgery, La Paz University Hospital, Madrid, Spain

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Carlos A. Encinas-Ullán Department of Orthopaedic Surgery, La Paz University Hospital, Madrid, Spain

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bone with small metaphyseal bone defects (cavity or contained, measuring less than 5 mm). These bone defects do not jeopardize the stability of the prosthetic component of the revision. In type 2, there is a loss of cortical bone and damage to the

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Cheuk Yin Li School of Medical Education, Newcastle University, Framlington Place, Newcastle upon Tyne, UK

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Kenneth Jordan Ng Cheong Chung School of Medical Education, Newcastle University, Framlington Place, Newcastle upon Tyne, UK

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Omar M. E. Ali School of Medical Education, Newcastle University, Framlington Place, Newcastle upon Tyne, UK

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Nicholas D. H. Chung School of Medical Education, Newcastle University, Framlington Place, Newcastle upon Tyne, UK

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Cheuk Heng Li School of Medical Education, Newcastle University, Framlington Place, Newcastle upon Tyne, UK

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. 99 Cytokines that cause pain primarily include IL-1β. 100 In addition, there is also evidence to suggest direct activation of nociceptor neurons by pathogens themselves. 101 A major cause for prosthetic joint infection is gram

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Marco Gupton MountainView Regional Medical Center, Orthopaedic Surgery Residency, Las Cruces, New Mexico, USA

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Jordan E Johnson MountainView Regional Medical Center, Orthopaedic Surgery Residency, Las Cruces, New Mexico, USA

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G Robert Cummings MountainView Regional Medical Center, Orthopaedic Surgery Residency, Las Cruces, New Mexico, USA

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Chenthuran Deivaraju Department of Orthopaedic Surgery, University of Minnesota, St Cloud, Minnesota, USA

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- and postoperative x-rays or advanced imaging; (iii) TKA performed for osteoarthritis; (iv) reported subjective and/or objective patient outcomes in relation to PFJ overstuffing; (v) patient follow-up of at least 1 year; (vi) prosthetic implant that is

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