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Tobias Winkler
Tobias Winkler
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
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Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
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Sven Geissler
Sven Geissler
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
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Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
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Tazio Maleitzke
Tazio Maleitzke
Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
Trauma Orthopaedic Research Copenhagen Hvidovre (TORCH), Department of Orthopaedic Surgery, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
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Trauma Orthopaedic Research Copenhagen Hvidovre (TORCH), Department of Orthopaedic Surgery, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
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Carsten Perka
Carsten Perka
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
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Georg N Duda
Georg N Duda
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
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Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
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Alexander Hildebrandt
Alexander Hildebrandt
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
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Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
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sections. Cartilage regeneration With an estimated prevalence of 40% in individuals over 70 years of age and an increasing global burden ( 9 ), osteoarthritis (OA) can be considered one of the most relevant musculoskeletal diseases of the 21st century
Claus Varnum
Claus Varnum
The Danish Hip Arthroplasty Register
Department of Orthopaedic Surgery, Vejle Hospital, Vejle, Denmark
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Department of Orthopaedic Surgery, Vejle Hospital, Vejle, Denmark
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Alma Bečić Pedersen
Alma Bečić Pedersen
Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark
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Per Hviid Gundtoft
Per Hviid Gundtoft
Department of Orthopaedic Surgery and Traumatology, Odense University Hospital, Odense, Denmark
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Søren Overgaard
Søren Overgaard
The Danish Hip Arthroplasty Register
Department of Orthopaedic Surgery and Traumatology, Odense University Hospital, Odense, Denmark
Orthopaedic Research Unit, Department of Clinical Research, University of Southern Denmark, Odense, Denmark
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Department of Orthopaedic Surgery and Traumatology, Odense University Hospital, Odense, Denmark
Orthopaedic Research Unit, Department of Clinical Research, University of Southern Denmark, Odense, Denmark
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confirmed after review of medical records and preoperative radiographs. For instance, the primary osteoarthritis diagnosis in the DHR could be confirmed in 85% of patients undergoing primary THA. 12 However, the PPV of the fresh hip fracture diagnosis
Achi Kamaraj
Achi Kamaraj
School of Clinical Medicine, University of Cambridge, Cambridge, UK
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Nikhil Agarwal
Nikhil Agarwal
Department of Surgery, University of Cambridge, Cambridge, UK
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K. T. Matthew Seah
K. T. Matthew Seah
Department of Surgery, University of Cambridge, Cambridge, UK
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Wasim Khan
Wasim Khan
Department of Surgery, University of Cambridge, Cambridge, UK
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replacement (THR) for older adult patients with osteoarthritis against either non-surgical therapy followed by THR once the patient had progressed to a functionally dependent state, or non-surgical therapy alone from the Italian national health system
T Gosens
T Gosens
Department of Orthopedic and Trauma Surgery, Elisabeth-TweeSteden Hospital, Tilburg, The Netherlands
Department of Medical and Clinical Psychology, Tilburg University, Tilburg, The Netherlands
Center of Research on Psychological and Somatic disorders (CoRPS), Tilburg University, Tilburg, The Netherlands
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Department of Medical and Clinical Psychology, Tilburg University, Tilburg, The Netherlands
Center of Research on Psychological and Somatic disorders (CoRPS), Tilburg University, Tilburg, The Netherlands
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B L den Oudsten
B L den Oudsten
Department of Medical and Clinical Psychology, Tilburg University, Tilburg, The Netherlands
Center of Research on Psychological and Somatic disorders (CoRPS), Tilburg University, Tilburg, The Netherlands
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Center of Research on Psychological and Somatic disorders (CoRPS), Tilburg University, Tilburg, The Netherlands
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problems. Why does one patient hardly suffer from a knee with a Kellgren–Lawrence grade 2 osteoarthritis while the other is significantly disabled? Why is one patient satisfied with the result after an artificial hip while the other experiences many
Ian Wilson
Ian Wilson
Concordia Joint Replacement Group, Winnipeg, Manitoba, Canada
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Eric Bohm
Eric Bohm
Canadian Joint Replacement Registry, University of Manitoba, Concordia Joint Replacement Group, Winnipeg, Manitoba, Canada
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Anne Lübbeke
Anne Lübbeke
Geneva Arthroplasty Registry, Division of Orthopaedic Surgery, Geneva University Hospitals, Geneva, Switzerland
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Stephen Lyman
Stephen Lyman
Hospital for Special Surgery and Weill Cornell Medical College, New York, New York, USA
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Søren Overgaard
Søren Overgaard
Danish Hip Arthroplasty Register, University of Southern Denmark, Odense, Denmark
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Ola Rolfson
Ola Rolfson
Swedish Hip Arthroplasty Register and Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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Annette W-Dahl
Annette W-Dahl
Swedish Knee Arthroplasty Register, Skåne University Hospital, Lund, Sweden
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Mark Wilkinson
Mark Wilkinson
University of Sheffield, Sheffield, United Kingdom
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Michael Dunbar
Michael Dunbar
Canadian Joint Replacement Registry, Dalhousie University, Halifax, Nova Scotia, Canada
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1996 Hip Yes 11 12 3 to 4 Knee Injury and Osteoarthritis Outcome score KOOS 1998 Knee No 44 42 10 to 15 KOOS short form (joint replacement) KOOS-JR 2007 Knee No Unknown 7 3 Hip Disability and
Richard N de Steiger
Richard N de Steiger
Australian Orthopaedic Association National Joint Replacement Registry, SAHMRI, Adelaide, Australia
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Brian R Hallstrom
Brian R Hallstrom
Michigan Arthroplasty Registry Collaborative Quality Initiative University of Michigan, Department of Orthopaedic Surgery, Ann Arbor, Michigan, USA
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Anne Lübbeke
Anne Lübbeke
Geneva Arthroplasty Registry, Geneva University Hospitals Rue Gabrielle-Perret-Gentil 4 CH-1211 Geneva, Switzerland
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Elizabeth W Paxton
Elizabeth W Paxton
Surgical Outcomes and Analysis Unit, Kaiser Permanente National Implant Registries 8954 Rio San Diego Drive, Suite, San Diego, California, USA
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Liza N van Steenbergen
Liza N van Steenbergen
Dutch Arthroplasty Register (Landelijke Registratie Orthopedische Implantaten (LROI)), Bruistensingel 230 | 5232 AD ’s-Hertogenbosch, The Netherlands
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Mark Wilkinson
Mark Wilkinson
Department of Oncology and Metabolism, University of Sheffield, Beech Hill Road, Sheffield, United Kingdom
National Joint Replacement for England, Wales, Northern Ireland, Isle of Man and the States of Guernsey (NJR)
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National Joint Replacement for England, Wales, Northern Ireland, Isle of Man and the States of Guernsey (NJR)
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comparator being all prosthesis combinations that have similar features to the device being examined, i.e. if the device is a cementless stem/cup combinations in patients with procedures performed for primary osteoarthritis. The outlier alert boundary is set
Anne Lübbeke
Anne Lübbeke
Division of Orthopaedic Surgery and Traumatology, Geneva University Hospitals, Switzerland; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, UK
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markers (e.g. current status of biomarkers for osteoarthritis and their use in approval studies 20 ) and biomechanical parameters (e.g. knee instability, 21 gait biomechanics in knee osteoarthritis 22 ). The use of surrogates instead of
Keijo T. Mäkelä
Keijo T. Mäkelä
Turku University Hospital and University of Turku, Finland, and the Finnish Arthroplasty Register
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Ove Furnes
Ove Furnes
Haukeland University Hospital, Bergen, Norway, and the Norwegian Arthroplasty Register
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Geir Hallan
Geir Hallan
Haukeland University Hospital, Bergen, Norway, and the Norwegian Arthroplasty Register
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Anne Marie Fenstad
Anne Marie Fenstad
Haukeland University Hospital, Bergen, Norway, and the Norwegian Arthroplasty Register
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Ola Rolfson
Ola Rolfson
Sahlgrenska University Hospital and University of Gothenburg, Sweden, and the Swedish Hip Arthroplasty Register
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Johan Kärrholm
Johan Kärrholm
Sahlgrenska University Hospital and University of Gothenburg, Sweden, and the Swedish Hip Arthroplasty Register
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Cecilia Rogmark
Cecilia Rogmark
Department of Orthopedics, Skåne University Hospital, Department of Clinical Sciences Malmö, Lund University, and the Swedish Hip Arthroplasty Register, Sweden
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Alma Becic Pedersen
Alma Becic Pedersen
Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark, and the Danish Hip Arthroplasty Register
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Otto Robertsson
Otto Robertsson
The Swedish Knee Arthroplasty Register, Department of Orthopedics, Skåne University Hospital, and Department of Clinical Sciences, Orthopedics, Lund University, Sweden
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Annette W-Dahl
Annette W-Dahl
The Swedish Knee Arthroplasty Register, Department of Orthopedics, Skåne University Hospital, and Department of Clinical Sciences, Orthopedics, Lund University, Sweden
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Antti Eskelinen
Antti Eskelinen
Coxa Hospital for Joint Replacement, Tampere, Finland, and the Finnish Arthroplasty Register
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Henrik M. Schrøder
Henrik M. Schrøder
Department of Orthopaedic Surgery, Naestved Hospital, Denmark, and the Danish Knee Arthroplasty Register
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Ville Äärimaa
Ville Äärimaa
Turku University Hospital and University of Turku, Finland, and the Finnish Arthroplasty Register
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Jeppe V. Rasmussen
Jeppe V. Rasmussen
Department of Orthopaedic Surgery, Herlev Hospital, University of Copenhagen, Denmark, and the Danish Shoulder Arthroplasty Register
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Björn Salomonsson
Björn Salomonsson
Department of Orthopedics, Karolinska Institutet, Danderyds Sjukhus AB, Sweden, and the Swedish Shoulder Arthroplasty Register
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Randi Hole
Randi Hole
Haukeland University Hospital, Bergen, Norway, and the Norwegian Arthroplasty Register
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Søren Overgaard
Søren Overgaard
Department of Orthopaedic Surgery and Traumatology, Odense University Hospital, Department of Clinical Research, University of Southern Denmark, and the Danish Hip Arthroplasty Register
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with metal-on-metal (MoM) bearings and metal-on-polyethylene (MoP) bearings. Focus on fixation methods of primary THA Pedersen et al assessed 29 558 primary THRs on patients with osteoarthritis (OA), aged < 55 years, performed from 1995 to
Yvet Mooiweer
Yvet Mooiweer
Department of Health Services Research, Carl von Ossietzky University, Oldenburg, Germany
Department of Orthopedics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
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Department of Orthopedics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
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Lina Roling
Lina Roling
School of Medicine and Health Sciences, Carl von Ossietzky University, Oldenburg, Germany
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Margaret Vugrin
Margaret Vugrin
Preston Smith Library, Texas Tech University Health Sciences Center, Lobbock, Texas, USA
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Lena Ansmann
Lena Ansmann
Department of Health Services Research, Carl von Ossietzky University, Oldenburg, Germany
Chair of Medical Sociology, Institute of Medical Sociology, Health Services Research and Rehabilitation Science (IMVR) Faculty of Medicine, University of Cologne, Oldenburg, Germany
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Chair of Medical Sociology, Institute of Medical Sociology, Health Services Research and Rehabilitation Science (IMVR) Faculty of Medicine, University of Cologne, Oldenburg, Germany
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Martin Stevens
Martin Stevens
Department of Orthopedics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
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Gesine H Seeber
Gesine H Seeber
Department of Orthopedics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
University Hospital of Orthopedics and Trauma Surgery Pius-Hospital, Medical Campus University of Oldenburg, Oldenburg, Germany
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University Hospital of Orthopedics and Trauma Surgery Pius-Hospital, Medical Campus University of Oldenburg, Oldenburg, Germany
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). Primary indication for THA and TKA is end-stage osteoarthritis (OA) ( 3 , 4 ). While every joint can be affected by OA, it is mainly the weight-bearing hip and knee joints which become symptomatic ( 5 ). THA and TKA are highly standardized procedures
Agnieszka Halm-Pozniak
Agnieszka Halm-Pozniak
Department of Orthopaedics, Otto-von-Guericke University Magdeburg, Germany
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Christoph H Lohmann
Christoph H Lohmann
Department of Orthopaedics, Otto-von-Guericke University Magdeburg, Germany
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Luigi Zagra
Luigi Zagra
IRCCS Istituto Ortopedico Galeazzi, Hip Department, Milan, Italy
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Benedikt Braun
Benedikt Braun
Department of Trauma and Reconstructive Surgery at the Eberhard Karls University Tübingen, BG Unfallklinik Tübingen, Germany
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Max Gordon
Max Gordon
Department of Clinical Sciences at Danderyd Hospital, Unit of Orthopedics, Karolinska Institutet, Stockholm, Sweden
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Bernd Grimm
Bernd Grimm
Department of Precision Health, Luxembourg Institute of Health, Human Motion, Orthopaedics, Sports Medicine, Digital Methods, Luxembourg
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-reported outcome measures (PROM) questionnaires such as Knee Injury and Osteoarthritis Outcome Score (KOOS) or Oxford Hip Score (OHS). However, the digital environment facilitates alternative self-assessment formats such as computer adaptive testing, single
