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Maria A. Smolle Department of Orthopaedics and Trauma, Medical University of Graz, Austria

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Dimosthenis Andreou Department of General Orthopaedics and Tumour Orthopaedics, University Hospital Muenster, Germany

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Per-Ulf Tunn Tumour Orthopaedics, HELIOS Klinikum Berlin-Buch, Germany

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Andreas Leithner Department of Orthopaedics and Trauma, Medical University of Graz, Austria

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allograft-prosthetic composite for proximal tibial bone sarcoma included (18 osteosarcomas, three Ewing sarcomas, one giant cell tumour) – mean follow-up of 6.5 years – mean implant survival of 68 months, with major complications including one infection, two

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Olga D. Savvidou First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘ATTIKON’ Hospital, Athens, Greece

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Panagiotis Koutsouradis Department of Orthopaedic Surgery, Mediterraneo Hospital, Athens, Greece

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Ioanna K. Bolia First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘ATTIKON’ Hospital, Athens, Greece

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Angelos Kaspiris Laboratory of Molecular Pharmacology/Sector for Bone Research, School of Health Sciences, University of Patras, Patras 26504, Greece

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George D. Chloros First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘ATTIKON’ Hospital, Athens, Greece

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Panayiotis J. Papagelopoulos First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘ATTIKON’ Hospital, Athens, Greece

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diffuse-type giant cell tumour (pigmented villonodular synovitis) and giant cell tumour of tendon sheath (nodular tenosynovitis) . J Bone Joint Surg Br 2012 ; 94 : 882 – 888 . 46. Inoue Y Ishida H Ueno H et al

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Catalin Cirstoiu Carol Davila University of Medicine and Pharmacy, Orthopedics and Traumatology Department, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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Bogdan Cretu Carol Davila University of Medicine and Pharmacy, Orthopedics and Traumatology Department, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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Bogdan Serban Carol Davila University of Medicine and Pharmacy, Orthopedics and Traumatology Department, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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Zsombor Panti Carol Davila University of Medicine and Pharmacy, Orthopedics and Traumatology Department, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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Mihai Nica Carol Davila University of Medicine and Pharmacy, Orthopedics and Traumatology Department, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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Distal radius reconstruction after giant cell tumour resection using fibular autograft. Bone allografts can be used for intercalary defects reconstruction or as osteochondral allografts, but often with modest long-term functional results. Despite

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Andrea Angelini Department of Orthopedics and Traumatology and Oncological Orthopedics, University of Padova, Italy

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Ivan Bohacek Department of Orthopaedic Surgery, University Hospital Centre Zagreb, School of Medicine, University of Zagreb, Salata, Zagreb, Croatia

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Mihovil Plecko Department of Orthopaedic Surgery, University Hospital Centre Zagreb, School of Medicine, University of Zagreb, Salata, Zagreb, Croatia

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Carlo Biz Department of Orthopedics and Traumatology and Oncological Orthopedics, University of Padova, Italy

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Giulia Trovarelli Department of Orthopedics and Traumatology and Oncological Orthopedics, University of Padova, Italy

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Mariachiara Cerchiaro Department of Orthopedics and Traumatology and Oncological Orthopedics, University of Padova, Italy

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Giuseppe Di Rubbo Department of Orthopedics and Traumatology and Oncological Orthopedics, University of Padova, Italy

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Pietro Ruggieri Department of Orthopedics and Traumatology and Oncological Orthopedics, University of Padova, Italy

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Wadia F Chaudhary K Anchan C George S & Dhawale A . Metachronous multicentric giant cell tumour of bone in a 12-year-old girl: a case report and review of literature . Journal of Orthopaedics, Trauma and Rehabilitation 2021 28 . ( https

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Elisa Pala Department of Orthopedics and Orthopedic Oncology, University of Padova, Padova, Italy

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Giulia Trovarelli Department of Orthopedics and Orthopedic Oncology, University of Padova, Padova, Italy

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Andrea Angelini Department of Orthopedics and Orthopedic Oncology, University of Padova, Padova, Italy

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Maria Chiara Cerchiaro Department of Orthopedics and Orthopedic Oncology, University of Padova, Padova, Italy

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Pietro Ruggieri Department of Orthopedics and Orthopedic Oncology, University of Padova, Padova, Italy

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kappa-B ligand, inhibiting bone resorption ( 27 ). Several studies reported the efficacy of denosumab in giant cell tumors, reducing tumor mass pre-operatively or in recurrences or inoperable lesions ( 27 ). A few papers reported denosumab as an

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James Wee Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, 308433, Singapore

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Gowreeson Thevendran Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, 308433, Singapore

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, and there is limited utility of CS as a mechanical buttress. The safety and efficacy of CS in treating long bone defects arising from trauma, infection and tumours is well documented in the literature, 36 - 38 with the option of incorporating

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Andreas F. Mavrogenis First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, Greece

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Vasilios G. Igoumenou First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, Greece

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Thekla Antoniadou First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, Greece

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Panayiotis D. Megaloikonomos First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, Greece

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George Agrogiannis Second Department of Pathology, National and Kapodistrian University of Athens, School of Medicine, Greece

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Periklis Foukas Second Department of Pathology, National and Kapodistrian University of Athens, School of Medicine, Greece

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Sotirios G. Papageorgiou Second Department of Internal Medicine, Hematology Unit, National and Kapodistrian University of Athens, School of Medicine, Greece

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including polymorphic granulomae, fibrosis, xanthogranulomatosis, proliferating fibroblasts, lymphocytic aggregates and Touton giant cells. 12 Fig. 1 Histopathological findings of ECD. Bone tissue sections show intense fibrohistiocytic infiltrate

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Xinhui Wu Department of Orthopedics, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China

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Xiaoxin Fang Department of Endocrinology and Metabolism, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China

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Feng Lu Nanjing Medical University, Jiangning, Nanjing, China

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Qiong Chen Jinhua TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China

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Junjian Liu Department of Orthopedics, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China

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Longpo Zheng Department of Orthopedics, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China
Orthopedic Intelligent Minimally Invasive Diagnosis and Treatment Center, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China

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). Osteoclast in the setting of ferroptosis Mature osteoclasts are multinucleated giant cells originating from the monocyte/macrophage lineage. Osteoclasts break down and absorb bone matrix by secreting H + and proteolytic enzymes like cathepsin K ( 69

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Elena Bravo Plastic Surgery Department, Hospital Universitario La Paz, Madrid, Spain

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Raul Barco Upper Limb Unit, Orthopedic Surgery Department, Hospital Universitario La Paz, Madrid, Spain

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E. Carlos Rodríguez-Merchán Haemophilia Orthopedic Unit, Orthopedic Surgery Department, Hospital Universitario La Paz, Madrid, Spain

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investigative method of choice. 24 A differential diagnosis must be made with several other types of lesion, including intraosseous synovial cysts, osteosarcoma, angioleiomyoma, aneurysmal bone cysts, giant cell tumours of the bone, and non

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Thomas Kozak Albany Health Campus, Albany, Australia
Royal Perth Hospital, Perth, Australia

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Stefan Bauer Ensemble Hospitalier de la Côte, Morges, Switzerland

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Gilles Walch Hôpital Privé Jean-Mermoz, Centre Orthopédique Santy, Lyon, France

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Saad Al-karawi Albany Health Campus, Albany, Australia

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William Blakeney Albany Health Campus, Albany, Australia
Royal Perth Hospital, Perth, Australia

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osteosarcoma, chondrosarcoma, giant cell tumour, and Ewing sarcoma or metastatic disease. Preservation of the axillary nerve and deltoid muscle function is essential for RTSA function and stability. 41 In cases where the deltoid insertion is resected from

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