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allograft-prosthetic composite for proximal tibial bone sarcoma included (18 osteosarcomas, three Ewing sarcomas, one giant cell tumour) – mean follow-up of 6.5 years – mean implant survival of 68 months, with major complications including one infection, two
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diffuse-type giant cell tumour (pigmented villonodular synovitis) and giant cell tumour of tendon sheath (nodular tenosynovitis) . J Bone Joint Surg Br 2012 ; 94 : 882 – 888 . 46. Inoue Y Ishida H Ueno H et al
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Distal radius reconstruction after giant cell tumour resection using fibular autograft. Bone allografts can be used for intercalary defects reconstruction or as osteochondral allografts, but often with modest long-term functional results. Despite
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Wadia F Chaudhary K Anchan C George S & Dhawale A . Metachronous multicentric giant cell tumour of bone in a 12-year-old girl: a case report and review of literature . Journal of Orthopaedics, Trauma and Rehabilitation 2021 28 . ( https
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kappa-B ligand, inhibiting bone resorption ( 27 ). Several studies reported the efficacy of denosumab in giant cell tumors, reducing tumor mass pre-operatively or in recurrences or inoperable lesions ( 27 ). A few papers reported denosumab as an
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, and there is limited utility of CS as a mechanical buttress. The safety and efficacy of CS in treating long bone defects arising from trauma, infection and tumours is well documented in the literature, 36 - 38 with the option of incorporating
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including polymorphic granulomae, fibrosis, xanthogranulomatosis, proliferating fibroblasts, lymphocytic aggregates and Touton giant cells. 12 Fig. 1 Histopathological findings of ECD. Bone tissue sections show intense fibrohistiocytic infiltrate
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). Osteoclast in the setting of ferroptosis Mature osteoclasts are multinucleated giant cells originating from the monocyte/macrophage lineage. Osteoclasts break down and absorb bone matrix by secreting H + and proteolytic enzymes like cathepsin K ( 69
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investigative method of choice. 24 A differential diagnosis must be made with several other types of lesion, including intraosseous synovial cysts, osteosarcoma, angioleiomyoma, aneurysmal bone cysts, giant cell tumours of the bone, and non
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osteosarcoma, chondrosarcoma, giant cell tumour, and Ewing sarcoma or metastatic disease. Preservation of the axillary nerve and deltoid muscle function is essential for RTSA function and stability. 41 In cases where the deltoid insertion is resected from