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Signe Steenstrup Jensen Department of Orthopedic Surgery and Traumatology, Lillebaelt Hospital, Kolding, Denmark
Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark

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Niels Martin Jensen Department of Orthopedic Surgery and Traumatology, Lillebaelt Hospital, Kolding, Denmark

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Per Hviid Gundtoft Department of Orthopedic Surgery and Traumatology, Aarhus University Hospital, Aarhus, Denmark

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Søren Kold Department of Orthopedic Surgery, Aalborg University Hospital, Aalborg, Denmark

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Robert Zura Department of Orthopedic Surgery, Louisiana State University Medical Center, New Orleans, Louisiana, USA

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Bjarke Viberg Department of Orthopedic Surgery and Traumatology, Lillebaelt Hospital, Kolding, Denmark
Department of Orthopedic Surgery and Traumatology, Odense University Hospital, Odense, Denmark
Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark

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factors were identified in the 30 studies included in this systematic review ( Fig. 4 ). Risk factors such as age, sex, smoking, open/closed fracture, Gustilo, diabetes, AO/OTA, infection, and obesity were included in more than five studies and were

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Lars Nonnenmacher Center for Orthopaedics, Trauma Surgery and Rehabilitation Medicine, University Medicine Greifswald, Greifswald, Germany

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Maximilian Fischer Center for Orthopaedics, Trauma Surgery and Rehabilitation Medicine, University Medicine Greifswald, Greifswald, Germany

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Lyubomir Haralambiev Center for Orthopaedics, Trauma Surgery and Rehabilitation Medicine, University Medicine Greifswald, Greifswald, Germany

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Sander Bekeschus ZIK plasmatis, Leibniz Institute for Plasma Science and Technology (INP), Greifswald, Germany

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Frank Schulze Center for Orthopaedics, Trauma Surgery and Rehabilitation Medicine, University Medicine Greifswald, Greifswald, Germany

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Georgi I Wassilew Center for Orthopaedics, Trauma Surgery and Rehabilitation Medicine, University Medicine Greifswald, Greifswald, Germany

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Janosch Schoon Center for Orthopaedics, Trauma Surgery and Rehabilitation Medicine, University Medicine Greifswald, Greifswald, Germany

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Johannes C Reichert Center for Orthopaedics, Trauma Surgery and Rehabilitation Medicine, University Medicine Greifswald, Greifswald, Germany

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outline the possible approaches in orthopaedics. We discuss CPP antimicrobial aspects in the light of clinical challenges in orthopaedics, such as periprosthetic joint infections (PJIs). In addition, the utilization of CPP in the treatment of bone

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Amer Sebaaly Department of Orthopedic Surgery, Bellevue Medical Center University Hospital, Faculty of Medicine, Saint Joseph University, Lebanon.
Department of Orthopedic Surgery, Spine Unit, Centre Hospitalier de l’Université de Montréal (CHUM), Canada.

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Maroun Rizkallah Department of Orthopedic Surgery, Bellevue Medical Center University Hospital, Faculty of Medicine, Saint Joseph University, Lebanon.

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Guillaume Riouallon Department of Orthopedic Surgery, Groupe Hospitalier Paris Saint Joseph, France.

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Zhi Wang Department of Orthopedic Surgery, Spine Unit, Centre Hospitalier de l’Université de Montréal (CHUM), Canada.

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Pierre Emmanuel Moreau Department of Orthopedic Surgery, Groupe Hospitalier Paris Saint Joseph, France.

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Falah Bachour Department of Orthopedic Surgery, Bellevue Medical Center University Hospital, Faculty of Medicine, Saint Joseph University, Lebanon.

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Ghassan Maalouf Department of Orthopedic Surgery, Bellevue Medical Center University Hospital, Faculty of Medicine, Saint Joseph University, Lebanon.

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.2%). 24 One should note that the open freehand technique tends to malposition the screw medially, whereas the malpositioned screw under fluoroscopy tended to be in the ‘safer’ lateral zone ( Fig. 5 ). 32 Finally, the infection rate with

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Piti Rattanaprichavej Department of Orthopaedics, Faculty of Medicine, Naresuan University, Phitsanulok, Thailand

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Patapong Towiwat Department of Internal Medicine, Faculty of Medicine, Naresuan University, Phitsanulok, Thailand

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Artit Laoruengthana Department of Orthopaedics, Faculty of Medicine, Naresuan University, Phitsanulok, Thailand

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Piyameth Dilokthornsakul Center of Pharmaceutical Outcomes Research, Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand
Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand

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Nathorn Chaiyakunapruk Department of Pharmacotherapy, College of Pharmacy, University of Utah, Salt Lake City, Utah, USA
School of Pharmacy, University of Wisconsin, Madison, Wisconsin, USA

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.5] 2 MCL avulsion, 1 patellar tendon rupture, 1 tibial tuberosity avulsion, 4 instability, 2 haematoma, 1 DVT, 1 superficial infection, 2 aseptic loosening, 1 PJI, 2 PPFx Bae DK (2009) 23 11 60.1 12.3 11 0 n/a n/a n/a n/a 0

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Mattia Alessio-Mazzola IRCCS Ospedale San Raffaele, Unità Clinica di Ortopedia e Traumatologia, Via Olgettina, Milan, Italy

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Giacomo Placella Università Vita-Salute San Raffaele, Via Olgettina, Milan, Italy

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Luigi Zagra Hip Department, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy

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Orlando Leone Università Vita-Salute San Raffaele, Via Olgettina, Milan, Italy

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Natasha Di Fabio Università Vita-Salute San Raffaele, Via Olgettina, Milan, Italy

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Desiree Moharamzadeh IRCCS Ospedale San Raffaele, Unità Clinica di Ortopedia e Traumatologia, Via Olgettina, Milan, Italy

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Vincenzo Salini Università Vita-Salute San Raffaele, Via Olgettina, Milan, Italy

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systematically review and meta-analyze the reported complications of TKA following ACL reconstruction including wound complications, stiffness, infection, deep venous thrombosis (DVT), patellar crepitus, patella baja, nerve injury, extensor mechanism damage and

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E. Carlos Rodríguez-Merchán Department of Orthopedic Surgery, La Paz University Hospital-IdiPaz, Madrid, Spain
Osteoarticular Surgery Research, Hospital La Paz Institute for Health Research – IdiPAZ (La Paz University Hospital – Autonomous University of Madrid), Madrid, Spain

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Hortensia De la Corte-Rodríguez Department of Physical and Rehabilitation Medicine, La Paz University Hospital, Madrid, Spain

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Carlos A. Encinas-Ullán Department of Orthopedic Surgery, La Paz University Hospital-IdiPaz, Madrid, Spain

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Primitivo Gómez-Cardero Department of Orthopedic Surgery, La Paz University Hospital-IdiPaz, Madrid, Spain

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and infection Deep venous thrombosis Revision surgery Recurrent instability Recurrent or persistent instability is a common complication of surgical treatment (reconstruction of MLKIs). Its published prevalence is 42%. 11

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Andreas Fontalis Royal National Orthopaedic Hospital NHS Trust, Brockley Hill, Stanmore, UK
Academic Unit of Bone Metabolism, University of Sheffield Medical School, Sheffield, UK

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Eustathios Kenanidis Academic Orthopaedic Unit, Aristotle University Medical School, Papageorgiou General Hospital, Thessaloniki, Greece
Centre of Orthopaedic and Regenerative Medicine (CORE), Center for Interdisciplinary Research and Innovation (CIRI), Aristotle University of Thessaloniki, Thessaloniki, Greece

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Katharine Bennett-Brown Chelsea and Westminster Hospital NHS Foundation Trust, Chelsea, London, UK

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Eleftherios Tsiridis Academic Orthopaedic Unit, Aristotle University Medical School, Papageorgiou General Hospital, Thessaloniki, Greece
Centre of Orthopaedic and Regenerative Medicine (CORE), Center for Interdisciplinary Research and Innovation (CIRI), Aristotle University of Thessaloniki, Thessaloniki, Greece

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outcomes included early (surgical site infection, pneumonia, urine infection, delirium, pulmonary embolism) and late complications (infection rate, loosening, dislocation and periprosthetic fractures), the implant of choice, surgical approach, length of

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Zaki Arshad University of Cambridge School of Clinical Medicine, Cambridge, UK

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Edward Jun-Shing Lau University of Cambridge School of Clinical Medicine, Cambridge, UK

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Aiman Aslam University of Cambridge School of Clinical Medicine, Cambridge, UK

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Azeem Thahir Department of Trauma and Orthopaedic Surgery, Addenbrooke’s Hospital, Cambridge, UK

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Matija Krkovic Department of Trauma and Orthopaedic Surgery, Addenbrooke’s Hospital, Cambridge, UK

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former describes direct contamination of bone due to trauma, surgical procedures/implants or local spread from contiguous sites of soft tissue infection or wounds. 2 , 3 Haematogenous osteomyelitis refers to nidation of pathogens present in the

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Cheuk Yin Li School of Medical Education, Newcastle University, Framlington Place, Newcastle upon Tyne, UK

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Kenneth Jordan Ng Cheong Chung School of Medical Education, Newcastle University, Framlington Place, Newcastle upon Tyne, UK

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Omar M. E. Ali School of Medical Education, Newcastle University, Framlington Place, Newcastle upon Tyne, UK

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Nicholas D. H. Chung School of Medical Education, Newcastle University, Framlington Place, Newcastle upon Tyne, UK

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Cheuk Heng Li School of Medical Education, Newcastle University, Framlington Place, Newcastle upon Tyne, UK

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joint operations were conducted compared to 4,417 revisions in 2008 in England, Wales, Northern Ireland and the Isle of Man. The most common causes for knee replacement revision in 2018 in descending order are aseptic loosening/lysis, infection, pain

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Gerhard M. Hobusch Medical University of Vienna, Department of Orthopaedics and Trauma Surgery, Vienna, Austria

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Kevin Döring Medical University of Vienna, Department of Orthopaedics and Trauma Surgery, Vienna, Austria

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Rickard Brånemark Gothenburg University, Gothenburg, Sweden
Biomechatronics Group, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

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Reinhard Windhager Medical University of Vienna, Department of Orthopaedics and Trauma Surgery, Vienna, Austria

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-reported outcome measures (PROMs) blur the boundaries between two aspects of amputation: the best surgical option OR the best possible medical care strategy to improve functional outcome and quality of life after failed surgery for infection, tumours or certain

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