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Lei Yao Sports Medicine Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China
Department of Orthopedics and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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Jie Cai West China School of Medicine, Sichuan University, Chengdu, Sichuan, China

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Junqiao Li Sports Medicine Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China
Department of Orthopedics and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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Yan Xiong Sports Medicine Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China
Department of Orthopedics and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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Jian Li Sports Medicine Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China
Department of Orthopedics and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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inflammatory cytokines and protein molecules in the evolution of knee diseases has been widely studied ( 10 , 32 , 33 , 34 , 35 ). Degenerative arthropathy has lesser levels of synovial fluid compared to traumatic or immune joint diseases, but inflammatory

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Charles Court Department of Orthopedic Surgery and Traumatology, Spine and tumor Unit, Bicetre University Hospital, Assistance Publique Hôpitaux de Paris, Paris Saclay University, Le Kremlin-Bicêtre, France

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Leonard Chatelain Department of Orthopedic Surgery and Traumatology, Spine and tumor Unit, Bicetre University Hospital, Assistance Publique Hôpitaux de Paris, Paris Saclay University, Le Kremlin-Bicêtre, France

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Barthelemy Valteau Department of Orthopedic Surgery and Traumatology, Spine and tumor Unit, Bicetre University Hospital, Assistance Publique Hôpitaux de Paris, Paris Saclay University, Le Kremlin-Bicêtre, France

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Charlie Bouthors Department of Orthopedic Surgery and Traumatology, Spine and tumor Unit, Bicetre University Hospital, Assistance Publique Hôpitaux de Paris, Paris Saclay University, Le Kremlin-Bicêtre, France

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. Retrospective analysis of 236 cases . Clinical Orthopaedics and Related Research 1988 227 67 – 81 . 17. Kweh BTS Tee JW Oner FC Schnake KJ Vialle EN Kanziora F Rajasekaran S Dvorak M Chapman JR Benneker LM , Evolution of the AO Spine

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Agnieszka Halm-Pozniak Department of Orthopaedics, Otto-von-Guericke University Magdeburg, Germany

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Christoph H Lohmann Department of Orthopaedics, Otto-von-Guericke University Magdeburg, Germany

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Luigi Zagra IRCCS Istituto Ortopedico Galeazzi, Hip Department, Milan, Italy

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Benedikt Braun Department of Trauma and Reconstructive Surgery at the Eberhard Karls University Tübingen, BG Unfallklinik Tübingen, Germany

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Max Gordon Department of Clinical Sciences at Danderyd Hospital, Unit of Orthopedics, Karolinska Institutet, Stockholm, Sweden

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Bernd Grimm Department of Precision Health, Luxembourg Institute of Health, Human Motion, Orthopaedics, Sports Medicine, Digital Methods, Luxembourg

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of the change process also bear risks that have to be considered. In orthopaedics and traumatology, this technical evolution has taken place in various forms that may support medical decision processes, surgical procedures, ease of communication with

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Arjun Sivakumar Centre for Orthopaedic & Trauma Research, University of Adelaide, Adelaide, South Australia, Australia

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Suzanne Edwards Adelaide Health Technology Assessment, University of Adelaide, Adelaide, South Australia, Australia

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Stuart Millar Centre for Orthopaedic & Trauma Research, University of Adelaide, Adelaide, South Australia, Australia

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Dominic Thewlis Centre for Orthopaedic & Trauma Research, University of Adelaide, Adelaide, South Australia, Australia

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Mark Rickman Centre for Orthopaedic & Trauma Research, University of Adelaide, Adelaide, South Australia, Australia
Department of Orthopaedics & Trauma, Royal Adelaide Hospital, Adelaide, South Australia, Australia

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( Supplement 6 ) S95 – S100 . ( https://doi.org/10.1016/j.otsr.2011.06.009 ) 23. Borger RA Borger FA Pires de Araujo R Pereira TF Queiroz RD . Prospective assessment of the clinical, radiographic and functional evolution of treatment for unstable

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Helen Anwander Department of Orthopaedic Surgery and Traumatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

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Philipp Vetter Department of Orthopaedic Surgery and Traumatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

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Christophe Kurze Department of Orthopaedic Surgery and Traumatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

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Chui J Farn Department of Orthopaedic Surgery and Traumatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
Department of Orthopedic Surgery, National Taiwan University Hospital, Taiwan, Republic of China

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Fabian G Krause Department of Orthopaedic Surgery and Traumatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

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://doi.org/10.1007/s11999-009-0885-8 ) 35. Giannini S Buda R Cavallo M Ruffilli A Cenacchi A Cavallo C Vannini F . Cartilage repair evolution in post-traumatic osteochondral lesions of the talus: from open field autologous chondrocyte to bone

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Di Zhao The Second Clinical School of Guangzhou University of Chinese Medicine, Guangzhou, China
Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China

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Ling-feng Zeng The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China

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Gui-hong Liang The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China

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Jian-ke Pan The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China

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Ming-hui Luo The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China

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Yan-hong Han The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China

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Jun Liu Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China
Guangdong Second Traditional Chinese Medicine Hospital (Guangdong Province Engineering Technology Research Institute of Traditional Chinese Medicine), Guangzhou, China
The fifth Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, China

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Wei-yi Yang The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China

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. ( https://doi.org/10.1007/s40265-017-0781-6 ) 25. Wise BL Seidel MF Lane NE . The evolution of nerve growth factor inhibition in clinical medicine . Nature Reviews: Rheumatology 2021 17 34 – 46 . ( https://doi.org/10.1038/s41584

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Michele Vasso Concordia Hospital for Special Surgery, Rome, Italy

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Alexander Antoniadis Bürgerspital Solothurn, Switzerland

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Naeder Helmy Bürgerspital Solothurn, Switzerland

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with the development and refinement of surgical techniques and implant design, has led to a favourable evolution of clinical results and, consequently, renewed interest in UKA. In selected patients, UKA has been shown to be a satisfactory and less

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Eustathios Kenanidis Academic Orthopaedic Department, Papageorgiou General Hospital, Aristotle University Medical School, Hellas, Greece
Center of Orthopaedics and Regenerative Medicine (C.O.RE.) – Center of Interdisciplinary Research and Innovation (C.I.R.I.) – Aristotle University Thessaloniki, Balkan Center, Hellas, Greece
Hôpital de la Tour, Geneva, Switzerland

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Konstantinos Kapriniotis Center of Orthopaedics and Regenerative Medicine (C.O.RE.) – Center of Interdisciplinary Research and Innovation (C.I.R.I.) – Aristotle University Thessaloniki, Balkan Center, Hellas, Greece

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Panagiotis Anagnostis Center of Orthopaedics and Regenerative Medicine (C.O.RE.) – Center of Interdisciplinary Research and Innovation (C.I.R.I.) – Aristotle University Thessaloniki, Balkan Center, Hellas, Greece

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Michael Potoupnis Academic Orthopaedic Department, Papageorgiou General Hospital, Aristotle University Medical School, Hellas, Greece
Center of Orthopaedics and Regenerative Medicine (C.O.RE.) – Center of Interdisciplinary Research and Innovation (C.I.R.I.) – Aristotle University Thessaloniki, Balkan Center, Hellas, Greece

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Panayiotis Christofilopoulos Hôpital de la Tour, Geneva, Switzerland

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Eleftherios Tsiridis Academic Orthopaedic Department, Papageorgiou General Hospital, Aristotle University Medical School, Hellas, Greece
Center of Orthopaedics and Regenerative Medicine (C.O.RE.) – Center of Interdisciplinary Research and Innovation (C.I.R.I.) – Aristotle University Thessaloniki, Balkan Center, Hellas, Greece

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patients reported a high level of failure and complications. 9 – 13 Recent diagnostic and therapeutic advances in the treatment of SCD have improved the life expectancy of sicklers 1 , 6 and the evolution of surgical techniques and implant design

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Yücel Ağırdil Department of Orthopaedics and Traumatology, İzzet Baysal State Hospital, Bolu, Turkey

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of bone growth, BMPs appear to have a significant signalling role in the differentiation of chondrocytes. 16 The Wnt signalling pathway is also important in chondrocyte development, stimulating their evolution into hypertrophic chondrocytes

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Matías Sepúlveda Universidad Austral de Chile, Valdivia, Chile
Hospital Base de Valdivia, Valdivia, Chile
AO Foundation, PAEG Expert Group, Davos, Switzerland

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Cecilia Téllez Universidad Austral de Chile, Valdivia, Chile
Hospital Base de Valdivia, Valdivia, Chile

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Víctor Villablanca Universidad Austral de Chile, Valdivia, Chile
Hospital Base de Valdivia, Valdivia, Chile

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Estefanía Birrer Universidad Austral de Chile, Valdivia, Chile
Hospital Base de Valdivia, Valdivia, Chile

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relationship with the magnitude or direction of the displacement. Gomes and Volpon ( 37 ) investigated the evolution of the physeal bars after Salter–Harris IV lesions, at the histological level. They showed that if the transphyseal fracture plane was not

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