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Heinz Winkler Osteitis Centre, Privatklinik Döbling Wien, Heiligenstaedter Strasse 57-63, A-1190 Wien, Austria

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remained inconclusive. 7 The authors of this study reported a 90% union rate but this requires a mean of 6.11 surgical interventions within a mean of 14.4 months to obtain union. 8 Other authors prefer resection of the altered osseous section and

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Jaime Esteban Servicio de Microbiología Clínica, Hospital Universitario Fundación Jiménez Díaz-IIS-Fundacion Jimenez Diaz, Universidad Autónoma de Madrid, Madrid, Spain

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Enrique Gómez-Barrena Servicio de Cirugía Ortopédica y Traumatología, Hospital Universitario La Paz-IdiPaz, Universidad Autónoma de Madrid, Madrid, Spain

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microorganism and alter the priorities to adequately treat each case. Without an appropriate aetiological diagnosis identifying the causing microorganism in PJI, the adequate treatment may not be established, including timely surgery and a precisely oriented

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Tobias Winkler Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany

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Sven Geissler Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany

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Tazio Maleitzke Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
Trauma Orthopaedic Research Copenhagen Hvidovre (TORCH), Department of Orthopaedic Surgery, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark

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Carsten Perka Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany

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Georg N Duda Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany

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Alexander Hildebrandt Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany

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-biased reporting, such as those offered by companies like Analgesics Solutions ( https://www.wcgclinical.com/analgesic-solutions/ ), might also be an appropriate approach to mitigate placebo effects. Detailed knowledge about the pathophysiology of the disease

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Thomas M Grupp Aesculap AG, Research & Development & Medical Scientific Affairs, Tuttlingen, Germany
Ludwig Maximilians University Munich, Department of Orthopaedic and Trauma Surgery, Musculoskeletal University Center Munich (MUM), Campus Grosshadern, Munich, Germany

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Sabine Rusch Aesculap AG, Research & Development & Medical Scientific Affairs, Tuttlingen, Germany

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Philippe Massin CMC Ambroise-Paré-Hartmann, Neuilly-sur-Seine, France

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Ashley Blom National Institute for Health Research Bristol Biomedical Research Centre, University Hospitals Bristol and Weston NHS Foundation Trust and the University of Bristol, Bristol, UK
Translational Health Sciences, Bristol Medical School, Musculoskeletal Research Unit, University of Bristol, Southmead Hospital, Bristol, UK

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Eduardo Garcia-Rey Hôpital Universitario La Paz-Idi Paz, Madrid, Spain
Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina, CIBER-BBN, Madrid, Spain

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Luca Cristofolini Department of Industrial Engineering, School of Engineering and Architecture, Alma Mater Studiorum - Università di Bologna, Bologna, Italy

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Dennis Janssen Radboud University Medical Center, Radboud Research Institute, Orthopaedic Research Lab, Nijmegen, the Netherlands

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Bernd Grimm Luxembourg Institute of Health, Human Motion, Orthopaedics, Sports Medicine & Digital Methods Group, Transversal Activities, Luxembourg

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Alexander Giurea Department of Orthopaedic Surgery, Medical University of Vienna, Vienna, Austria

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Marcus Jäger Department of Orthopaedics, Trauma & Reconstructive Surgery St. Marien Hospital Mülheim an der Ruhr & Chair of Orthopaedics and Trauma Surgery University of Duisburg–Essen, Essen, Germany

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Francesco Siccardi Medacta International SA, Research & Development & Medical Affairs, Castel San Pietro, Switzerland

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Søren Overgaard Copenhagen University Hospital, Department of Orthopaedic Surgery and Traumatology, Copenhagen, Denmark
Department of Clinical Medicine, Faculty of Health & Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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uncertainty’ causes a certain discouragement in medical device innovation. Successful cases of collaboration between manufacturers, academia, health institutions and regulatory agencies for developing advanced medical devices have been reported ( 2

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AliSina Shahi The Rothman Institute at Thomas Jefferson University, Philadelphia, USA

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Javad Parvizi The Rothman Institute at Thomas Jefferson University, Philadelphia, USA

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diagnostic evaluation in patients with suspected PJI. Reports have shown a sensitivity of 91% and specificity of 72% for ESR and a sensitivity of 94% and specificity of 74% for CRP. 7 , 9 , 17 ESR and CRP are well-known biomarkers of systemic responses

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Peter H. Richter Orthopaedic Trauma Department, Universität Ulm, Germany

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Florian Gebhard Orthopaedic Trauma Department, Universität Ulm, Germany

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Alexander Eickhoff Orthopaedic Trauma Department, Universität Ulm, Germany

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Konrad Schütze Orthopaedic Trauma Department, Universität Ulm, Germany

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-arm computed tomography evaluation of syndesmotic reduction: case report . Foot Ankle Int 2013 ; 34 : 753 - 9 . 18. Verma SK Singh PK Agrawal D . O-arm with navigation versus C-arm: a review of screw placement over 3

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The International Orthopaedic Diversity Alliance Claudia Arias, Dafina Bytyqui, Linda Chokotho, Vivian P.C. Chye, Deborah Eastwood, Li Felländer-Tsai, Ana Filipa Garcez, Simon Fleming, Margaret Fok, Jennifer Green, Elham Hamdan, Laurie A. Hiemstra, Caroline B. Hing, Magaly Iniguez, Ian Incoll, Anthony Johnson, Carrie Kollias, Philippe Liverneaux, Violet Lupondo, Katre Maasalu, Margy Pohl, Julie Balch Samora, Paula Sarmiento, Matthew Schmitz, Adriaan van Zyl, Kristy Weber

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resources and requires the government to ensure that Maori have at least the same level of health as non-Maori. Currently, this is not the case, with Maori having significantly worse health outcomes. Ensuring all surgeons have an understanding of the role

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Maria-Pau Ginebra Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Metallurgical Engineering, Universitat Politècnica de Catalunya (UPC), Spain

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Montserrat Espanol Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Metallurgical Engineering, Universitat Politècnica de Catalunya (UPC), Spain

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Yassine Maazouz Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Metallurgical Engineering, Universitat Politècnica de Catalunya (UPC), Spain
Mimetis Biomaterials, Spain

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Victor Bergez Mimetis Biomaterials, Spain

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David Pastorino Mimetis Biomaterials, Spain

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function bone fulfils a series of metabolic and physiological functions. Here also the mineral phase plays a very relevant role. The apatite nanocrystals function as a chemical reservoir of both calcium (Ca) and phosphorus (P) in the body. In the case that

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Heiner Fangerau Department for the History, Philosophy and Ethics of Medicine, Medical Faculty, Heinrich-Heine University Duesseldorf Centre Health & Society, Moorenstraße 5, Düsseldorf, Germany

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pauperise the senses and to weaken their clinical acuity’ ( 9 , 10 ). At the same time, other doctors reported an increase in patient demand and their own use of technical devices in diagnostics. According to these proponents, the new technologies were

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Thomas Collins Trauma & Orthopaedics, Wythenshawe Hospital, Wythenshawe, UK

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Dinesh Alexander Trauma & Orthopaedics, Salford Royal Hospital, Salford, UK

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Bilal Barkatali Trauma & Orthopaedics, Salford Royal Hospital, Salford, UK

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cartilage pathology. A total of 29 studies were included, nine prospective RCTs, four prospective comparative studies, 14 case series, and two retrospective comparative studies. Of the nine RCTs, all reported improved symptoms with PRP groups at the final 12

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