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• Overuse injuries imply the occurrence of a repetitive or an increased load on a specific anatomical segment which is unable to recover from this redundant microtrauma, thus leading to an inflammatory process of tendons, physis, bursa, or bone.

• Even if the aetiology is controversial, the most accepted is the traumatic one.

• Limb malalignment has been cited as one of the major risk factors implicated in the development of overuse injuries.

• Many authors investigated correlations between anatomical deviations and overuse injuries, but results appear mainly inconclusive.

• Establishing a causal relationship between mechanical stimuli and symptoms will remain a challenge, but 3D motion analysis, musculoskeletal, and finite element modelling may help in clarifying which are the major risk factors for overuse injuries.

• Anterior cervical surgery (ACS) owes its development to various pioneering individuals whose revolutionary works form key advances and guide current medical decisions. This bibliometric study aimed to identify, analyse and visualize the main features of the most-cited papers in ACS.

• The citation count for the top 100 most-cited articles ranged from 148 to 1,197, and citations per year ranged from 3.1 to 89.8. The articles were published from 1958 to 2016, with the 2000s being the most active decade. There was an inverse correlation between the average citations per year since publication and article age.

• The oldest as well as most-cited two articles were both published in 1958 by Smith and Robinson, and Cloward, respectively. In their studies, the authors individually described the technique of anterior cervical discectomy with fusion (ACDF).

• The most popular keywords were: ‘fusion’ (22), ‘spine’ (20), ‘cervical spine’ (16), ‘complications’ (15), ‘arthrodesis’ (13), ‘interbody fusion’ (13), ‘bone morphogenetic protein’ (13), and ‘radiculopathy’ (12).

• ACDF was the most frequent surgical procedure (80%), while cervical disc arthroplasty is of gradual greater impact.

• The surgical techniques of ACDF have remained unaltered for over 60 years. More attempts are needed to promote its development.

Cite this article: EFORT Open Rev 2021;6:1203-1213. DOI: 10.1302/2058-5241.6.210074

• Bioabsorbable and biodegradable implants offer new possibilities in orthopaedic and trauma surgery. As soon as the initial stability of the degradable implants has reached the qualities of conventional materials, new devices may find usage in younger and more demanding patients. Residual conventional osteosynthetic material or the necessity to remove metal increasingly seems to be more of an adverse event than daily practice in forefoot surgery. Nevertheless, some drawbacks need to be discussed.

• Recent literature screened for the use of bioabsorbable and biodegradable materials in forefoot surgery, available implants and indications in forefoot surgery were analysed and summarized. Apart from common indications in forefoot surgery, points of interest were the type of biomaterial, the process of biodegradation and biointegration, and possible adverse events. Materials were comprehensively discussed for each indication based on the available literature.

• Polylactide, polyglycoside and polydioxanone are considered safe and sufficiently stable for use in forefoot surgery. Low complication rates (e.g. 0.7% for pin fixation in hallux deformities) are given.

• Magnesium implants suffered from an extensive corrosive process in the first generation but now seem to be safe in forefoot surgery and offer good options compared with conventional titanium screws, especially in procedures of the first ray.

• Allograft bone has proven feasibility in small case series, but still lacks larger or randomized clinical trials. The first results are promising.

• Bioresorbable and osseointegrating devices offer attractive new possibilities for surgeons and patients. Despite all the known advantages, the difficulties and possible complications must not be forgotten, such as soft tissue reactions, unwanted osteolysis and a lower primary mechanical load capacity.

Cite this article: EFORT Open Rev 2021;6:1132-1139. DOI: 10.1302/2058-5241.6.200157

• Robot-assisted total hip arthroplasty (THA), in comparison to conventional THA, improves radiographic outcomes, but it remains unclear whether it alters complication rates, clinical and functional outcomes, and implant survival.

• The purpose of this systematic overview was to summarize the findings of the most recent meta-analyses that compare clinical and surgical outcomes of robot-assisted versus conventional THA.

• Two readers independently conducted an electronic literature search, screening and data extraction from five electronic databases. Inclusion criteria were: meta-analyses evaluating robot-assisted versus conventional THA in terms of radiographic outcomes, clinical and functional scores, and complications and revision rates. The literature search returned 67 records, of which 14 were duplicates and 49 were excluded, leaving three meta-analyses published within the past two years for data extraction and analysis.

• The present overview of meta-analyses suggests that, compared to conventional THA (n = 3011), robot-assisted THA (n = 1813) improves component placement and reduces intraoperative complications. The overview also affirms that robot-assisted THA could extend surgery by 20 minutes, and increases risks of postoperative heterotopic ossification, dislocation, and revision. None of the meta-analyses found significant differences in clinical or functional scores between robot-assisted and conventional THA.

• Future studies and reviews should make a clear distinction between active and semi-active robotic assistance, address technology matureness, and describe the experience of surgeons with robotic assistance.

Cite this article: EFORT Open Rev 2021;6:1157-1165. DOI: 10.1302/2058-5241.6.200121

• Regional analgesia has been introduced successfully into the postoperative pain management after total knee arthroplasty, reducing pain scores, opioid use and adverse effects.

• Combination of regional analgesia techniques is associated with better pain management and lower side effects than single regional techniques.

• Adductor canal block provides good analgesia and considerably lower detrimental effect in muscular strength than femoral nerve block, enhancing surgical recovery.

• Infiltration techniques may have equivalent analgesic effect than epidural analgesia and peripheral nerve blocks, however there should be awareness of dose dependent toxicity.

• Novel long-acting local anesthetics role for regional analgesia is still to be determined, and will require larger randomized trials to support its advantage over traditional local anesthetics.

Cite this article: EFORT Open Rev 2021;6:1181-1192. DOI: 10.1302/2058-5241.6.210045

• To report clinical and radiographic outcomes of primary THA using three-dimensional (3D) image-based custom stems.

• This systematic review was performed according to PRISMA guidelines and registered with PROSPERO (CRD42020216079). A search was conducted using MEDLINE, Embase and Cochrane. Clinical studies were included if they reported clinical or radiographic outcomes of primary THA using 3D image-based custom stems. Studies were excluded if specific to patients with major hip anatomical deformities, or if not written in English.

• Fourteen studies were eligible for inclusion (n = 1936 hips). There was considerable heterogeneity in terms of manufacturer, proximal geometry, coating and length of custom stems. Revision rates ranged from 0% to 1% in the short-term, 0% to 20% in the mid-term, and 4% to 10% in the long-term, while complication rates ranged from 3% in the short-term, 0% to 11% in the mid-term and 0% to 4% in the long-term. Post-operative Harris hip scores ranged from 95 to 96 in the short-term, 80 to 99 in the mid-term, and 87 to 94 in the long-term. Radiographic outcomes were reported in eleven studies, although none reported 3D implant sizing or positioning, nor compared planned and postoperative hip architecture.

• Primary THA using 3D image-based custom stems in unselected patients provides limited but promising clinical and radiographic outcomes. Despite excellent survival, the evidence available in the literature remains insufficient to recommend their routine use. Future studies should specify proximal geometry, length, fixation, material and coating, as well as management of femoral offset and anteversion. The authors propose a classification system to help distinguish between custom stem designs based primarily on their proximal geometry and length.

Cite this article: EFORT Open Rev 2021;6:1166-1180. DOI: 10.1302/2058-5241.6.210053

• Adequate sagittal balance (SB) is essential to maintain an upright, efficient, and painless posture. It has been shown that sagittal profile alterations affect quality of life of patients with a similar or even greater impact than chronic disease.

• Evaluation of the SB has gained much relevance in recent years, with recognition of its importance in the evaluation of spinal pathology.

• This review summarizes the basic principles of SB, aiming to obtain a practical, simple and understandable evaluation of the sagittal profile of a patient.

• SB is a dynamic process that involves a varying degree of energy expenditure. Distinguishing between a balanced, compensated imbalance or decompensated imbalanced patient, is relevant to diagnosis and therapeutic decision-making.

Cite this article: EFORT Open Rev 2021;6:1193-1202. DOI: 10.1302/2058-5241.6.210062

• Bone and joint infections are difficult to treat, and increasing antibiotic resistance has only made them more challenging. This has led to renewed interest in phage therapy (PT). The aim of this systematic review was to determine success rate, current treatment modalities and safety of PT in bone and joint infections.

• A systematic search of PubMed, EMBASE and Cochrane databases as well as the journal PHAGE for literature published between January 2000 and April 2021 was conducted according to PRISMA guidelines to identify all human studies assessing bacteriophages as therapy for bone and joint infections. All study designs and patient populations were eligible. The review’s primary outcome was success rate.

• Twenty records describing a total of 51 patients and 52 treatment episodes were included. No randomized controlled studies were identified. The overall success rate was 71% (n = 37/52). Topical administration alone was the most frequent administration route (85%, n = 44/52). Antibiotics were administered concomitantly with PT in the majority of treatments (79%, n = 41/52), and surgery was performed for 87% (n = 45/52) of treatment episodes. Four minor adverse events related to PT were reported, representing 8% (n = 4/52) of treatment episodes.

• PT for bone and joint infections has not been evaluated in any randomized controlled clinical study, and current administration modalities are highly variable between case reports and case series. While publications included here show potential benefit and few adverse effects, clinical trials are warranted to assess the efficacy of PT for bone and joint infections and determine optimal treatment modalities.

Cite this article: EFORT Open Rev 2021;6:1148-1156. DOI: 10.1302/2058-5241.6.210073